Primary Neuroendocrine Tumors of the Endometrium: Management and Outcomes

Zhang, Jingjing; Pang, Li

doi:10.3389/fonc.2022.921615

Cited by 5 publications

(8 citation statements)

References 26 publications

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“…For advanced-stage tumors, platinum + etoposide chemotherapy is the recommended first-line treatment [77,108]. Of interest, an analysis of 170 patients with endometrial NETs from the SEER database, including SCNECs (N = 56), LCNECs (N = 60), and other NECs not elsewhere classified (N = 51), found that adding surgery to chemotherapy, with or without radiotherapy, may improve survival outcomes in patients with advanced disease [109], thus suggesting that surgery could be considered in select patients, when feasible. For locally advanced disease, radical surgery could be considered in selected cases (dashed line).…”

Section: Necs Of the Endometriummentioning

confidence: 99%

Extrapulmonary Neuroendocrine Carcinomas: Current Management and Future Perspectives

Stumpo,

Formelli,

Persano

et al. 2023

JCM

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Neuroendocrine carcinomas (NECs) are poorly differentiated and highly aggressive epithelial neuroendocrine neoplasms. The most common primary site is the lung, but they may arise in every organ. Approximately 37% of extrapulmonary NECs (EP-NECs) occur in the gastroenteropancreatic (GEP) tract, followed by the genitourinary (GU) system and gynecological tract. As a result of their rarity, there is scant evidence to guide treatment recommendations, and a multidisciplinary approach is essential for the management of such patients. Platinum-based chemotherapy currently represents the standard of care for EP-NECs of any site, mirroring the management of small-cell lung cancer (SCLC), but further approaches are still under investigation. Indeed, ongoing trials evaluating targeted therapies, immune checkpoint inhibitors (ICIs), and radionuclide therapy could provide potentially breakthrough therapeutic options. Given the relative dearth of evidence-based literature on these orphan diseases, the aim of this review is to provide an overview of the pathology and current treatment options, as well as to shed light on the most pressing unmet needs in the field.

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Section: Necs Of the Endometriummentioning

confidence: 99%

Extrapulmonary Neuroendocrine Carcinomas: Current Management and Future Perspectives

Stumpo,

Formelli,

Persano

et al. 2023

JCM

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“…Endometrial neuroendocrine carcinoma (NEC) is a rare type of endometrial cancer that originates from endocrine cells in the neural ectoderm, neural crest, and neural endoderm [3] and is characterized by high invasive and metastatic potential. Endometrial NEC, also known as endometrial high-grade neuroendocrine neoplasm (NEN), accounts for less than 1% of all endometrial cancers [4]. NENs can occur in various organs and are frequently observed in the gastrointestinal tract (62-70%), followed by the lung (25%) [3,5].…”

Section: Introductionmentioning

confidence: 99%

“…A previous retrospective study from the National Cancer Database (NCDB) showed that endometrial NEC patients had a worse prognosis than endometrioid endometrial carcinoma patients, and the hazard ratio (HR) of death was 2.32 (95% CI, 1.88-2.88) [8]. In addition, largecell neuroendocrine carcinoma has been found to have a greater risk of distant metastasis than small-cell neuroendocrine carcinoma [4]. However, due to its rarity, there are currently no guidelines or consensuses for the management of endometrial NEC.…”

Section: Introductionmentioning

confidence: 99%

“…However, due to its rarity, there are currently no guidelines or consensuses for the management of endometrial NEC. Although two large studies have summarized the clinicopathologic characteristics and prognosis of endometrial NEC using the SEER database and the National Cancer Database (NCDB) [4,8], additional cases are needed to summarize the therapy and prognosis of endometrial NEC.…”

Section: Introductionmentioning

confidence: 99%

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Neuroendocrine carcinoma of the endometrium: a retrospective analysis of data from a single center

Liu,

Tian,

Yan

et al. 2024

BMC Cancer

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Background Neuroendocrine carcinoma (NEC) originating from the endometrium is rare, and there is limited knowledge regarding its diagnosis and optimal management. In this study, we present our experience with 11 patients with endometrial NEC, aiming to provide guidance for clinical practice. Methods We retrospectively collected the clinical, pathological, and treatment data of 11 patients with endometrial NEC who were treated at the First Affiliated Hospital of Zhengzhou University from January 2011 to July 2023. The clinicopathological characteristics, treatment and prognosis of these patients were analyzed. Results The median age of the patients was 55.0 (39.0–64.0) years, and the median tumor size was 40.0 (33.0–60.0) mm. Irregular vaginal bleeding was the most common symptom observed in 10 out of 11 patients, while metabolic syndrome occurred in only 2 out of 11 patients. Six out of the 11 patients were diagnosed at an early stage. Among the patients, 6 were diagnosed with endometrial NECs, while the remaining patients had a combination of endometrial NEC and other non-NEC endometrial carcinomas. All patients underwent surgery, except for one who received only chemotherapy due to multiple metastases. After surgery, adjuvant chemotherapy was administered to 5 patients, chemotherapy combined with radiotherapy was given to 3 patients, and 2 patients did not receive any adjuvant therapy. A total of 10 patients completed the follow-up, with a median follow-up time of 51.0 (14.3–81.0) months. Unfortunately, 2 patients died from the disease. Conclusion NECs originating from the endometrium might not be affected by metabolic disorders. Preoperative diagnosis of these tumors was challenging. The primary approach for managing endometrial NEC can be multimodal treatment centered around surgery.

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“…Treatment options include surgery, radiation therapy, and chemotherapy; however, the optimal management of this type of cancer is not well established[ 8 ]. The prognosis is generally poor with a high risk of recurrence and metastasis[ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Neuroendocrine carcinoma of the endometrium concomitant with Lynch syndrome: A case report

Siu,

Hong,

Ding

2023

World J Clin Cases

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The modern medical education system has gradually evolved starting from 1910 incorporating the suggestions by Abraham Flexner, his public disclosure of the poor conditions at many medical schools provided a means to galvanize all the constituencies needed for reform to occur. He could say what other reformers could not, due to their links to the medical education community. But now we are again going back to a pre-Flexnerian state due to multiple reasons such as gradually diminishing importance of basic science subjects for the students, the decline in the number and quality of investigator initiated research among clinical researchers, lesser emphasis to bedside training by means of detailed clinical examination and making appropriate observation of signs to reach to a diagnosis rather than over reliance on the laboratory tests and radiological modalities for the diagnosis, poor exposure to basic clinical skills starting from college throughout residency and the trend of disrespect and absenteeism from both theoretical and clinical/practical classes. The attitude of students is just to complete their required attendance so that they are not barred from appearing in examinations. This de-Flexnerization trend and regression to pre-Flexnerian era standards, ideologies, structures, processes, and attitudes, are bound to beget pre-Flexnerian outcomes, for you get what you designed for.

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Primary Neuroendocrine Tumors of the Endometrium: Management and Outcomes

Cited by 5 publications

References 26 publications

Extrapulmonary Neuroendocrine Carcinomas: Current Management and Future Perspectives

Extrapulmonary Neuroendocrine Carcinomas: Current Management and Future Perspectives

Neuroendocrine carcinoma of the endometrium: a retrospective analysis of data from a single center

Neuroendocrine carcinoma of the endometrium concomitant with Lynch syndrome: A case report

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