Primary neuroendocrine tumors of the ear, nose and throat: A report of three cases and a review of the literature

Mhawej, Rachad; Farah, Chadi; Haddad, A.; Tabchy, Bassam

doi:10.3892/ol.2015.3606

Cited by 10 publications

(9 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The surgical method is selected based on the property, location, and area of the tumor. 3 Well-differentiated NECs progress slowly with a low risk of metastasis and can be removed by local mass resection. Due to the high risk of metastasis, moderately differentiated NECs should be treated with partial or total laryngectomy combined with selective bilateral cervical lymph node dissection.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A Rare Case of Primary Neuroendocrine Carcinomas in the Ear and Throat and Review of Literatures

Wang

Qin

et al. 2020

Ear Nose Throat J

View full text Add to dashboard Cite

The neuroendocrine carcinomas (NECs) of the head and neck are rare. The purpose of this article is to explore the diagnosis and treatment of NECs in the ear and larynx. We report a case of a patient with NECs found in the ear and throat simultaneously, and the relevant literatures are reviewed. It is difficult to identify which is the original site. There is no specific clinical manifestation of NECs in the ear and throat, and carcinoid syndrome is a rare situation. Surgery is still the preferred treatment for this disease. For patients with metastasis, radiotherapy and/or chemotherapy are required.

show abstract

Section: Discussionmentioning

confidence: 99%

“…An 82-year-old male patient presented with left ear pain and left facial dyskinesia, which he had begun suffering 3 months before. At onset of symptoms, he started to have left ear pain and hearing loss with occasional bloody discharge for no known reason, as well as left side facial palsy.…”

Section: Case Reportmentioning

confidence: 99%

A Rare Case of Primary Neuroendocrine Carcinomas in the Ear and Throat and Review of Literatures

Wang

Qin

et al. 2020

Ear Nose Throat J

View full text Add to dashboard Cite

show abstract

“…The treatment of laryngeal typical carcinoid tumor is conservative surgery such as wide local excision or partial laryngectomy (15,16). If necessary neck dissections can be added to the procedure (1).…”

Section: Case Reportmentioning

confidence: 99%

Histopathologically TTF-1 and Calcitonin Positive Laryngeal Typical Carcinoid Tumor with Elevated Serum Calcitonin

et al. 2016

View full text Add to dashboard Cite

Even with 1% of the incidence, laryngeal neuroendocrine tumors are the second common tumors in larynx; as a subtype, typical carcinoid tumors are extremely rare. We presented a case of laryngeal typical carcinoid tumor and we discussed diagnostic criteria and treatment of these tumors. A 57-year-old male with a 3 months history of hoarseness was examined endoscopically and a laryngeal mass on left supraglottic area was seen. High levels of serum calcitonin were detected. The histopathological analysis of biopsy material was typical carcinoid tumor. Laryngeal tumor resection and left neck dissection were performed. The histopathologic result was TTF 1 and calcitonin positive primer laryngeal typical carcinoid tumor with cervical lymphoid metastasis. Serum calcitonin level returned to normal levels postoperatively. The distinction between laryngeal carcinoid tumors and metastasis of thyroid medullary carcinoma are difficult histopathologically. So, laryngeal carcinoid tumors should be kept in mind in these circumstances.

show abstract

“…NETs of the sinonasal and orbital regions are rare, aggressive and have a high recurrence potential 2 3. Owing to their rarity, there is limited data regarding the management of sinonasal NETs.…”

Section: Introductionmentioning

confidence: 99%

Diagnosis and treatment of a rare sinonasal neuroendocrine tumour: adding to the evidence

et al. 2016

View full text Add to dashboard Cite

Sinonasal neuroendocrine tumours (NETs) are rare, aggressive neoplasms with a high recurrence potential. There are no robust protocols for the management of these tumours. An 81-year-old man presented with an incidental sinonasal mass visualised on CT scan of head. Over the next few weeks he developed new onset, progressively worsening headache, right eye ptosis and restricted extraocular movements. Imaging confirmed a rapidly enlarging tumour involving the right nasal cavity and the orbit. Biopsy showed a large cell neuroendocrine carcinoma of the right ethmoidal sinus. The patient was treated with concurrent cisplatin chemotherapy and radiation. Repeat imaging showed decrease in tumour volume. The patient continues to do well and follows up regularly with our oncology service. Current protocols comprising chemotherapy after radiation are based on limited studies. A regimen involving concurrent chemoradiation also appears to aid in tumour volume reduction. Additional studies are required to formulate robust clinical protocols for management of sinonasal NETs.

show abstract

Primary neuroendocrine tumors of the ear, nose and throat: A report of three cases and a review of the literature

Cited by 10 publications

References 20 publications

A Rare Case of Primary Neuroendocrine Carcinomas in the Ear and Throat and Review of Literatures

A Rare Case of Primary Neuroendocrine Carcinomas in the Ear and Throat and Review of Literatures

Histopathologically TTF-1 and Calcitonin Positive Laryngeal Typical Carcinoid Tumor with Elevated Serum Calcitonin

Diagnosis and treatment of a rare sinonasal neuroendocrine tumour: adding to the evidence

Contact Info

Product

Resources

About