Primary non-hodgkin′s lymphoma of bone: Experience of a decade

Abstract

Diffuse large B-cell lymphoma is the commonest type of primary non Hodgkin's lymphoma of bone in the Pakistani population. It is common in all ages. The sites most often involved are femur followed by hip bone. Primary non Hodgkin's lymphoma of bone appears to be more common in males. Our results are comparable to international data with various studies also showing that diffuse large B cell non Hodgkin lymphoma is the commonest primary bone lymphoma. However, primary Bone Lymphoma is more common in children and young adults.

Clinical features, management and prognosis of multifocal primary bone lymphoma: a retrospective study of the international extranodal lymphoma study group (the IELSG 14 study)

“…It affects patients at any age, with a slight predominance in males of the fifth to sixth decade, with diffuse large B-cell lymphoma (DLBCL) being the most common histological subtype (90% of cases) (Jones et al, 1999;Hsieh et al, 2006;Qureshi et al, 2010).…”

Diffuse large B-cell lymphoma of bones in a patient after allogeneic hematopoietic stem cells transplantation due to Hodgkin’s lymphoma

“…It is estimated that they constitute approximately 7% of all bone cancers and 5% of all extralymphatic lymphomas [11]. The most common histological subtype is DLBCL, accounting for about 80% of cases in Western countries [12,13]. The rarity of the presence of lymphomas in bones, as well as the diversity of the clinical course of the disease, makes it difficult to establish the rules of the treatment.…”

Primary Bone Lymphoma of Humerus Diagnosed by FNAC- A Rare Case Report

“…A core biopsy is recommended for cases in which FNA fails to provide good aspirates. Most primary lymphoma of bone are either diffuse large B-cell lymphoma or mixed large cell and small cell lymphoma, although other types of lymphoma, including small lymphocytic lymphoma, anaplastic large cell lymphoma, Burkitt's lymphoma and Hodgkin's lymphoma are described [1,5,7,9]. Immunocytochemical studies, including antibodies to CD20, CD3, CD45 are sufficient to establish a definitive diagnosis.…”

“…Primary bone lymphoma is rare accounting for less than 1 % of all Non-Hodgkin's lymphoma [4][5][6][7]. The criteria for diagnosis of PLB is suggested by Coley are as follows: 'Lymphoma presenting in an osseous site with no evidence of disease elsewhere for at least 6 months after diagnosis' [7][8][9].…”

“…Primary lymphoma of bone usually responds well to a combination of radiotherapy and chemotherapy with an overall response rate of 94 % in some series and a 5-year survival rate, better than that achieved with most other primary osseous malignancy [1,2,4,5]. CHOP regime is the standard first-line treatment [1,6,8,9].…”