Primary non-Hodgkin's lymphoma of the liver

Noronha, Vanita; Shafi, Nelofar; Obando, J. Antonio; Kummar, Shivaani

doi:10.1016/j.critrevonc.2004.10.010

Cited by 180 publications

(236 citation statements)

References 43 publications

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“…The median survival time of patients with PHL is reported to be 15 months; however, it varies widely and ranges from 3 to 124 months (2). Thus far, the prognosis of PHL has not been assessed on the basis of its histologic origin.…”

Section: Discussionmentioning

confidence: 99%

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Primary Hepatic Peripheral T-Cell Lymphoma Treated with Corticosteroid

et al. 2011

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Primary hepatic lymphoma is a very rare condition, and the majority of the cases reported are of B-cell origin. We report a case of a 65-year-old man with primary hepatic peripheral T-cell lymphoma, not otherwise specified (PTCL-nos) who presented with 15% weight loss and general fatigue over the previous 9 months. Imaging studies and bone marrow examination could not confirm a diagnosis of lymphoma. Liver biopsy was performed because of an elevated soluble interleukin-2 receptor (sIL-2R) level (17,000 U/I) and hepatomegaly. After the diagnosis of primary hepatic PTCL-nos, treatment with low-dose corticosteroid was initiated, and the sIL-2R level decreased. Discontinuation of corticosteroid treatment resulted in the reelevation of the sIL-2R level, and subsequently, treatment with low-dose corticosteroid was reinitiated. The sIL-2R level decreased rapidly, and the patient is alive with no evidence of lymphoma for 50 months after diagnosis. Thus, we found that a low-dose corticosteroid was effective in the long-term control of the disease, whereas many previous studies reported that primary hepatic PTCL-nos has a poor prognosis.

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Section: Discussionmentioning

confidence: 99%

“…In the majority of the cases of PHL originates in B cells, and T-cell lymphoma is less common as only a few cases of primary hepatic T-cell lymphoma have been reported (2). Multi-agent chemotherapy was applied in most of the cases with a confirmed pathological diagnosis of lymphoma.…”

Section: Introductionmentioning

confidence: 99%

Primary Hepatic Peripheral T-Cell Lymphoma Treated with Corticosteroid

et al. 2011

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“…Although secondary liver involvement of lymphoma in the advanced stage is common, primary liver lymphoma (PLL), which is defined as lymphoma either confined to the liver or having major liver involvement, is extremely rare [1,2]. PLL constitutes 0.4% of cases of extranodal non-Hodgkins lymphoma, and comprises approximately 0.01% of non-Hodgkin's lymphomas [1].…”

Section: Discussionmentioning

confidence: 99%

“…PLL constitutes 0.4% of cases of extranodal non-Hodgkins lymphoma, and comprises approximately 0.01% of non-Hodgkin's lymphomas [1].…”

Section: Discussionmentioning

confidence: 99%