Primary Non-Hodgkin's Lymphoma of the Radial Nerve

Abstract

Primary B-cell lymphoma of the peripheral nerve is exceedingly rare and to date has not been reported as an isolated occurrence in the radial nerve. We present a patient who is alive and disease free 65 months after incomplete excision and limited chemotherapy.

Positron emission tomography/computerized tomography imaging of multiple focus of neurolymphomatosis

“…[124] Of note, most of the lymphomatous involvement of peripheral nerves described in the literature involves the sciatic nerve. [5] It is described during or following chemotherapy with good response to the original presenting systemic disease. Most case reports demonstrate diffuse or solitary thickening of the nerves/nerve sheath and nerve roots, and rarely, as a mass.…”

MRI and pet-CT in the diagnosis and follow-up of a lymphoma case with multifocal peripheral nerve involvement

“…Most of the reported cases of primary peripheral nerve lymphomas have heralded the onset of systemic lymphoma, whereas there have been few cases found in patients with known systemic disease. In either case, it may be a harbinger of a more disseminated disease involving the peripheral and central nervous systems (1,4,8,9). The B-cell type of non-Hodgkin lymphoma is the predominant type involving the peripheral nerves, with the NK/T-cell subtype being extremely rare (2,4,8).…”

“…Various treatment approaches have been applied, including chemotherapy, radiotherapy, and surgery, alone and in various combinations (11). Prophylactic and therapeutic intrathecal methotrexate therapy is also commonly used because these patients have an increased risk of central nervous system relapse (1,4,8,9).…”

“…The literature regarding peripheral nerve lymphoma is deficient, with most consisting of case reports (1,3,4). Peripheral nerve lymphoma can present as diffuse or nodular nerve thickening, or as a mass, with this latter variety of involvement being very rare.…”

Primary multifocal lymphoma of peripheral nervous system: Case report and review of the literature

“…In a subset of primary NL, lymphoma cells are found uniquely in the PNS, and this disorder is designated as primary lymphoma of peripheral nerves (PLPNs). As far as we know, only 15 cases of PLPNs have been described to date (see Table S1, available online) …”