Primary non-Hodgkin's lymphoma of the tongue: a diagnostic dilemma of unusual case presentation

Al‐Rawi, Natheer H

doi:10.1136/bcr-2016-218218

Cited by 4 publications

(4 citation statements)

References 25 publications

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“…[ 4 5 ] However, a few asymptomatic cases have also been reported, as evidenced in the review of the literature [ Table 1 ]. [ 1 4 5 6 7 8 9 10 11 12 13 ]…”

Section: Discussionmentioning

confidence: 99%

An evidence based immunohistochemical panel for diagnosing oral lymphoma along with a case series

Aneesh,

Carvalho,

Dhupar

et al. 2024

Journal of Family Medicine and Primary Care

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Oral lymphomas are rare and present a diagnostic challenge. Immunophenotyping is essential to decipher their biology and identify therapeutic targets. Histopathology can prove to be diagnostically difficult to type these lesions, and hence, immunohistochemistry (IHC) proves useful in deciphering their biology. Here, we present an evidence-based approach using a novel immunohistochemical marker panel to diagnose oral lymphomas by discussing four unique cases.

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“…[ 4 5 ] However, a few asymptomatic cases have also been reported, as evidenced in the review of the literature [ Table 1 ]. [ 1 4 5 6 7 8 9 10 11 12 13 ]…”

Section: Discussionmentioning

confidence: 99%

An evidence based immunohistochemical panel for diagnosing oral lymphoma along with a case series

Aneesh,

Carvalho,

Dhupar

et al. 2024

Journal of Family Medicine and Primary Care

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“…Other risk factors such as viruses commonly associated with NHL include Epstein-Barr virus, human T-cell lymphotropic virus-1 (HTLV), human herpesvirus-8 (HHV8), human type C retrovirus, HIV, SV40, and Helicobacter pylori. [11,12] Other risk factors for NHL are immunosuppression, ultraviolet radiation, autoimmune and chronic inflammatory disorders (rheumatoid arthritis, Sjogren's syndrome, and SLE), and occupational exposures (pesticides such as phenoxy acids, organophosphates, and organochlorines). [7,9] Clinically, NHL in the base of tongue may present with local swelling, pain or discomfort, voice changes, dysphagia or odynophagia due to ulceration, and upper airway obstruction.…”

Section: Discussionmentioning

confidence: 99%

“…NHL in the oral cavity has a clinical picture similar to other common benign oral lesions. [11] Possible differential diagnoses include Squamous Cell Carcinoma (SCC), the most common malignancy of the base of the tongue, salivary gland malignancies (adenoid cystic carcinoma or mucoepidermoid carcinoma), and infection process such as tuberculosis. [12,14] Defining the stages of oropharyngeal lymphoma and other nodal lymphomas also requires CT of the head, neck, chest, abdomen, and pelvis.…”

Section: Discussionmentioning

confidence: 99%

Challenges in the Diagnosis of Extranodal Non-Hodgkin’s Lymphoma of the Base of Tongue: A Rare Case Report

Prabawa,

Rena

2023

International Journal of Scientific Advances

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Introduction: Primary non-Hodgkin’s lymphomas (NHLs) of the oral cavity, especially in the tongue, are extremely rare and account for 1% of all malignant tumors of the oral cavity, accounting for 7% of all primary Waldeyer’s ring NHLs. Clinical features are non-specific ulcerative lesions that do not heal, making its diagnosis challenging. Fine-needle aspiration biopsy was helpful in the early diagnosis of the intraoral NHL involving a cervical lymph node. Case Report: we present a rare case of extranodal NHL of the base of tongue in a 55-year-old female who presented with a mass in the base of the tongue with cervical lymphadenopathy. The diagnosis was confirmed as primary NHL diffuse large B cell type by histopathological and immunohistochemistry results. Conclusion: A careful clinical evaluation supported by histopathological and radiologic investigations will help identify the disease early, resulting in a better prognosis.

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“…1,2 NHL accounts for up to 90% of lymphomas in this region and can be further subdivided into those of nodal or extranodal origin. 2,3 While primary extranodal lymphomas typically arise from mucosa-associated lymphoid tissues (MALT) within the gastrointestinal tract, 4-6 another common site of involvement is Waldeyer’s ring (WR), a circular band of tissue at the opening of the aerodigestive tract comprised of the adenoids, tubal tonsils, and soft palate superiorly, palatine tonsils laterally, and base of tongue and lingual tonsils inferiorly. 7,8 Up to 93% of primary lymphomas of WR localize to the palatine tonsils or nasopharynx, however, with rare involvement of the tongue.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology and Prognostic Indicators of Survival in Tongue Lymphoma

Hong

Simpson

et al. 2022

Ann Otol Rhinol Laryngol

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Objectives: Lymphoma, categorized as either non-Hodgkin’s lymphoma or Hodgkin’s lymphoma, is the second most common malignancy in the head and neck. Primary tongue lymphoma is exceedingly rare, with only case reports or small case series in the literature. This population-based analysis is the first to report the epidemiology and prognostic factors of survival in patients with primary tongue lymphoma. Methods: The Surveillance, Epidemiology, and End Results 18 database from the National Cancer Institute was queried for patients diagnosed between the years 2000 and 2016 with tongue lymphoma. Outcomes of interest were overall and disease-specific survival. Independent variables included age at diagnosis, sex, race, marital status, primary subsite, histologic subtype, stage, and treatment type. Results and Conclusion: Seven hundred forty patients met criteria; the male-female ratio was 1.5:1 and the mean age at diagnosis was 67.8 years. The majority of lesions localized to the base of tongue (90.0%), were histologically diffuse large B-cell lymphoma (59.5%), and presented at stage I or II (77.9%). Most early-stage lymphomas were treated with chemotherapy only (40.5%) or a combination of both chemotherapy and radiation (31.3%), while late-stage cancers were primarily treated with chemotherapy alone (68.5%). In multivariate analysis, younger age at diagnosis, female sex, married/partnered marital status, mucosa-associated lymphoid tissue histologic subtype, and earlier cancer stage were found to be associated with improved survival. Chemotherapy treatment with or without radiation was also associated with better survival compared to no treatment or radiation alone, though data regarding immunotherapy was unavailable.

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Primary non-Hodgkin's lymphoma of the tongue: a diagnostic dilemma of unusual case presentation

Cited by 4 publications

References 25 publications

An evidence based immunohistochemical panel for diagnosing oral lymphoma along with a case series

An evidence based immunohistochemical panel for diagnosing oral lymphoma along with a case series

Challenges in the Diagnosis of Extranodal Non-Hodgkin’s Lymphoma of the Base of Tongue: A Rare Case Report

Epidemiology and Prognostic Indicators of Survival in Tongue Lymphoma

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