Primary non-hodgkin’s lymphoma of the male breast: a case report

Abstract

A 69-year-old Japanese man presented with bilateral gynecomastia and a soft, mobile and clearly defined mass beneath the left nipple. A round radiopaque masswas revealed on mammography. The tumor was homogeneous, hypoechoic and measured2.4 x 3.9 cm on ultrasonography. Based on a diagnosis of malignant lymphoma by needle aspiration cytology, a modified radical mastectomy with ipsilateral axillary lymph node dissection was performed. Malignant diffuse large B-cell type lymphoma was diagnosed histologically. Whole body examinations revealed no evidenceof other tumors. Three courses of adjuvant CHOP therapy were subsequently performed. The patient is free of recurrence 12 months after surgery. Primary non-Hodgkin's lymphoma (NHL) of the male breast is extremely rare. The occurrence of lymphoma in this patient could be related to elevated estrogen levels.

Bilateral primary lymphoma of the breast: A case report initially diagnosed by FNAC

“…19 Review of the literature concerning cytologically diagnosed PNHLB reveals a few case reports or a very limited number of small series. 17,[31][32][33][34][35] In agreement with our evaluation, the most common diagnostic dilemma in those cases has been lymphoma or poorly differentiated carcinoma, but the lack of cell clusters or molding, and the observation of lymphoglandular bodies, and the nuclear and cytoplasmic characteristics favored the former (correct) diagnosis. Moreover, the publications of bilateral PNHLB at presentation investigated by FNAC are extremely rare.…”

Primary breast lymphoma: a case report

“…However, cases in men have been reported. 3 According to the various series published, the average age of onset of lymphoma is between 42 and 69 years, with a peak frequency at 60 years and extreme ages from 19 to 91 years. 4,5 Few data exist on the oncogenesis of PBL.…”

“…Rare cases of PBL with expression of hormone receptors (progestins and estrogen) by lymphomatous cells have been reported. [1][2][3][4][5][6] In the group of primitive large B-cell lymphomas of the breast, certain known cytogenetic abnormalities, recurrent in these lymphomas, have been reported in 50% of cases with deregulating translocations bcl-2 [t (12; 18), t (14; 18 )], and anomalies involving bcl-6 [t (3; 14) and der (3) (q27)]. 7 The most common presenting mode is a painless unilateral mass on breast examination (60% to 100% of cases).…”

Diffuse Large B-Cell Lymphoma with Involvement of the Breast and Testis in a Male Patient

“…Extranodal NHL of the breast is uncommon, and its occurrence in male patients is extremely rare [ 1 ]. Table 1 provides an overview of previously reported cases of male primary breast lymphoma (PBL) [ 3 - 13 ]. None of these cases presented with metastatic disease at first presentation, but three patients relapsed at other sites, including the CNS, bone marrow, cervical lymph nodes, and adrenal glands.…”

“…None of these cases presented with metastatic disease at first presentation, but three patients relapsed at other sites, including the CNS, bone marrow, cervical lymph nodes, and adrenal glands. The majority [ 3 , 4 , 8 , 10 , 11 , 13 ] of patients were diagnosed with DLBCL.…”