1983
DOI: 10.1002/1097-0142(19830601)51:11<2048::aid-cncr2820511115>3.0.co;2-t
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Primary non-Hodgkin's lymphoma of the central nervous system. Results of radiotherapy in 15 cases

Abstract: Primary non‐Hodgkin's lymphoma (NHL) of the central nervous system is a rare disease. The number of cases reported in the literature does not exceed 200. The current series comprises 15 cases of primary NHL of the CNS. In 12 cases material for pathology was obtained at surgery. In the other three cases the diagnosis was established by cytologic examination of the cerebrospinal fluid (CSF). The type of lymphoma was predominantly the diffuse lymphocytic type. All the patients received irradiation on the whole br… Show more

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Cited by 81 publications
(14 citation statements)
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“…In 22 of the patients marked improvement was noted in neurological status and on CT scan after irradiation. This reflects the marked radiosensitivity of these tumours (10,26,27).…”
Section: Discussionmentioning
confidence: 94%
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“…In 22 of the patients marked improvement was noted in neurological status and on CT scan after irradiation. This reflects the marked radiosensitivity of these tumours (10,26,27).…”
Section: Discussionmentioning
confidence: 94%
“…However, most patients eventually get recurrence within CNS (26,27). Combination chemotherapy following surgery and radiotherapy seems to improve the survival rate (28,29).…”
mentioning
confidence: 99%
“…No patients had any signs of extraneural involvement on staging procedures. Cerebrospinal fluid (CSF) cytology was examined in eight patients by the method described previously, l 9 and was positive in two patients with multiple lesions (7,30).…”
Section: Methodsmentioning
confidence: 99%
“…Five-year survival following radiotherapy is reported at 3% Lymphoma cells were reported in the cerebrospinal fluid (CSF) in 10% of patients on diagnosis (83). Opinions diverge on whether the entire craniospinal canal should be irradiated, several groups recommend it if CSF analysis reveals lymphoma cells (84,85), while others suggest that it leads to complications in later chemotherapy (81). Orbital involvement has been reported in up t o 25% of cases during the course of the disease (82), and therefore the posterior orbit should be included in the target volume (84,86).…”
Section: Primarv Cns Lymphomamentioning
confidence: 99%