Primary Nucleation of Vanillin Explored by a Novel Multicell Device

Pino-García, Osvaldo; Rasmuson, Åke C.

doi:10.1021/ie0210412

Cited by 31 publications

(43 citation statements)

References 30 publications

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“…Table 1 (column 4) lists the γ-values calculated from the slopes of the straight lines at high σ at each temperature. The numerical values of γ (≈ 3.9 to 6.5 mJ/m 2 ) are similar to those reported for other organic compounds [26]. Table 1 (columns 3 and 4) shows interesting trends in t ind and γ.…”

Section: Effect Of Supersaturation On Crystallization Induction Timesupporting

confidence: 83%

Effect of supersaturation on the crystallization of phenylbutazone polymorphs

Datta

Grant²

2005

Cryst. Res. Technol.

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The article describes the effect of degree of supersaturation, σ, on the crystallization of specific polymorphs of phenylbutazone from its methanolic solution at 20°C. At low initial supersaturation, σ ≤ 2.0, the fraction of the metastable α polymorph in the crystallized product exceeds that of the δ polymorph, while at σ ≥ 5.0, the fraction of the stable δ polymorph increases in the crystallized product. The results are explained by the effect of supersaturation on the relative rates of nucleation and crystal growth of the polymorphs. Furthermore, the mechanism of nucleation and crystal growth also change with supersaturation. Supersaturated methanolic solutions of phenylbutazone exhibit a critical temperature at which the nucleation rates of the polymorphs decrease drastically. This effect is partly explained by the decreased mobility of phenylbutazone molecules at lower temperatures. Nucleation is most rapid when the crystallization temperature is close to the transition temperature, T t (α↔δ), between the polymorphs, α and δ. The nucleation rate decreases as the temperature difference between T t (α↔δ) and the crystallization temperature increases.

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Section: Effect Of Supersaturation On Crystallization Induction Timesupporting

confidence: 83%

Effect of supersaturation on the crystallization of phenylbutazone polymorphs

Datta

Grant²

2005

Cryst. Res. Technol.

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“…There are several approaches for the estimation of nucleation kinetics from MSZW or induction times, including the stochastic probability distribution model approach [14][15][16][17][18][19][20][21][22][23] and the empirical power law model approach [11,[24][25][26][27][28][29][30][31][32][33]. Each approach builds on different assumptions.…”

Section: Introductionmentioning

confidence: 99%

Validation of Models Predicting Nucleation Rates from Induction Times and Metastable Zone Widths

Maosoongnern

Flood

2018

Chem Eng & Technol

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Three approaches for estimation of nucleation rates from induction time and metastable zone width (MSZW) were validated based on directly measured nucleation rates for paracetamol in ethanol. To quantitatively predict nucleation kinetics using Kubota's methods it is necessary to know the minimum detectable number concentration of nuclei. This was found by determination of light transmission of a series of diluted suspensions of newly nucleated crystals where the size had already been assessed by optical reflection measurement (ORM). The measured nucleation rates strongly depended on both temperature and supersaturation. The Nyvlt method predicted nucleation rates in this system reasonably well; however, it gave slightly low estimates for all temperatures. The methods of Kubota provided nucleation rates that were low by an order of magnitude.

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“…Both mechanisms are insufficiently understood, and process development is largely based on applied experiments on the particular compound of interest. [10][11][12][13][14][15][16][17] . In order to form a nucleus of crystalline material that is thermodynamically stable at the prevailing conditions, the free energy barrier, arising as a result of the competition between the favorable crystal bulk free energy and the unfavorable solidliquid interfacial energy, needs to be surpassed.…”

Section: Introductionmentioning

confidence: 99%