Primary Open-Angle Glaucoma vs Normal-Tension Glaucoma

Mroczkowska, Stephanie; Benavente-Perez, Alexandra; Negi, Anil; Sung, Velota; Patel, Samip; Gherghel, Doina

doi:10.1001/2013.jamaophthalmol.1

Cited by 75 publications

(53 citation statements)

References 80 publications

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“…Further studies are needed to determine the alterations in the lamina cribrosa in patients with migraine. In addition, alterations in the ocular and systemic circulation have been demonstrated in patients with glaucoma [38]. …”

Section: Discussionmentioning

confidence: 99%

The Impact of Migraine on Posterior Ocular Structures

Demircan

Ataş

Yüksel

et al. 2015

Journal of Ophthalmology

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Purpose. To investigate the thickness of the retinal nerve fiber layer (RNFL) and choroid in patients who have migraines in comparison to healthy controls. Methods. This study included 76 eyes and patients in the migraine group, 36 with aura (MWA group) and 40 without (MWoA group), and 38 eyes as control subjects. The RNFL and macular thicknesses were analysed with standard OCT protocol while choroidal thickness was analysed with EDI protocol in all subjects. Choroidal thickness was measured at the fovea, 1500 µm nasal and 1500 µm temporal to the fovea in a horizontal section. Results. The mean RNFL thickness for nasal and nasal inferior sectors was significantly thinner (P ≤ 0.018) in the migraineurs' eyes than in those of the controls, as was the mean choroid thickness at the fovea and measured points (P < 0.0001). However, the mean macular thickness was not significantly different between the groups. Conclusions. This study suggests that migraine leads to a reduction in the peripapillary RNFL thickness and to thinning in choroidal structures. These findings can be explained by a chronic ischemic insult related to migraine pathogenic mechanisms and these findings are considered supportive of the relationship between glaucoma and migraine.

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Section: Discussionmentioning

confidence: 99%

The Impact of Migraine on Posterior Ocular Structures

Demircan

Ataş

Yüksel

et al. 2015

Journal of Ophthalmology

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“…However, elevated intraocular pressure (IOP) and insufficient blood supply to the optic disc are generally accepted as key risk factors. Particularly, systemic vascular factors have been shown to be related to the pathogenesis of open-angle glaucoma (OAG), regardless of whether the diagnosis was normal-tension glaucoma or high-tension OAG [4]. Moreover, the high incidence of systemic cerebrovascular and cardiovascular morbidity and mortality in patients with glaucoma supports this vascular perspective [5–7].…”

Section: Introductionmentioning

confidence: 99%

Albuminuria Is Associated with Open-Angle Glaucoma in Nondiabetic Korean Subjects: A Cross-Sectional Study

Kim

Park

et al. 2016

PLoS ONE

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ObjectiveSystemic vascular dysfunction has been suggested to contribute to glaucomatous damage. Albuminuria is a surrogate marker of endothelial injury, including vessels. However, their relationship is not well understood. This study aimed to investigate the association between albuminuria and the prevalence of open-angle glaucoma (OAG) in nondiabetic subjects.MethodsWe conducted a cross-sectional study of 4186 nondiabetic participants aged 19 years or older from the 2011–2012 Korea National Health and Nutrition Examination Survey. OAG was defined based on the criteria of the International Society for Geographic and Epidemiologic Ophthalmology. Urinary albumin excretion was assessed by the urinary albumin-to-creatinine ratio (UACR). A multivariate logistic regression analysis was performed to evaluate the relationship between albuminuria and OAG.ResultsAmong the subjects, 124 had OAG. The weighted prevalences of microalbuminuria (UACR of 30–299 mg/g creatinine [Cr]) and macroalbuminuria (UACR ≥ 300 mg/g Cr) were 3.2 ± 0.3% and 0.4 ± 0.1%, respectively. The percentages of OAG increased in accordance with increasing UACR tertiles. Compared with subjects in the lower UACR tertile, those in the upper tertile showed an increased prevalence of OAG (odds ratio, 1.963; 95% confidence interval 1.072–3.595, P = 0.029) after adjusting for demographic factors, laboratory parameters, kidney function, and intraocular pressure. Furthermore, even after excluding 155 subjects with microalbuminuria and 19 subjects with macroalbuminuria, a positive association persisted between the upper UACR tertile (low-grade albuminuria) and an increased prevalence of OAG (odds ratio, 2.170; 95% confidence interval, 1.174–4.010, P = 0.014).ConclusionAlbuminuria, even low-grade, was significantly associated with OAG in nondiabetic subjects. This result implies the role of vascular endothelial dysfunction in the pathogenic mechanism of OAG and suggests that careful monitoring of OAG is required in nondiabetic subjects with albuminuria.

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“…Recent studies have suggested that POAG is a disease continuum extending from a predominantly IOP-dependent entity (pure POAG) to a predominantly IOP-independent entity (pure NTG) [48–50]. Additionally, it has been proposed that the onset and progression of both forms of glaucoma, POAG, and NTG, are dictated by a degree of interaction between IOP and vascular factors [51]. …”

Section: Discussionmentioning

confidence: 99%

Is normal-tension glaucoma a risk factor for stroke?—A 10-year follow-up study

et al. 2017

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ObjectivesTo investigate whether patients with normal-tension glaucoma (NTG) have a higher incidence of stroke.DesignA population-based retrospective cohort study based on data from the Taiwan National Health Insurance Research Database (NHIRD) from January 1, 2001, to December 31, 2010.MethodsData were retrospectively collected from the NHIRD. A total of 245 (20.1%) patients with a history of stroke at the time of glaucoma diagnosis were excluded, and 1,218 patients with NTG who were 20 years of age and older were identified. Patients’ age, gender and pre-existing comorbidities, including hypertension, diabetes, congestive heart failure, ischemic heart disease, atrial fibrillation and disorders of lipid metabolism, were recorded. The propensity score method with a 1:5 matching ratio was used to minimize selection bias. Cox regression with robust variance estimation was used to estimate the hazard ratio (HR) of developing stroke between the NTG and control groups.ResultsAfter adjusting for patient age, gender, and pre-existing comorbidities, the HR was 6.34, indicating that the incidence of stroke was significantly higher in patients with NTG than in controls. Furthermore, a higher risk of stroke was also found in most subgroups with the above-mentioned comorbidities.ConclusionNTG is a significant risk factor for subsequent stroke in most of the described comorbidity subgroups. Early interventions for stroke prevention should be provided to newly diagnosed patients with NTG.

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Primary Open-Angle Glaucoma vs Normal-Tension Glaucoma

Cited by 75 publications

References 80 publications

The Impact of Migraine on Posterior Ocular Structures

The Impact of Migraine on Posterior Ocular Structures

Albuminuria Is Associated with Open-Angle Glaucoma in Nondiabetic Korean Subjects: A Cross-Sectional Study

Is normal-tension glaucoma a risk factor for stroke?—A 10-year follow-up study

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