Primary Oral Mucosal Melanoma: A Series of 35 New Cases From South America

Abstract

Oral mucosal melanoma is rare and reported to be more aggressive than its cutaneous counterpart. Due to the rarity of this entity, data on epidemiology, tumor behavior, treatment, follow-up, and survival of patients are mainly based on single case reports. The few existing series of patients show that oral mucosa melanoma has its peak between 41 and 60 years of age, and male to female ratio is 2:1. Preferred oral sites include hard palate and maxillary alveolar crests. Risk factors have not been clearly identified, and surgical treatment is still the treatment of choice for oral mucosal melanomas. The authors retrospectively studied 35 patients with primary melanoma of the oral cavity to report their clinical and pathological features, such as age, sex, site of the tumor, metastasis, treatment, response to therapy, and outcome. We found no significant sex predominance, and the mean age of the patients was 60.6 years, with a range from 9 to 91 years. The majority of the patients (71.42%) had palate commitment, and invasive histopathological aspect was observed in 80% of the specimens (grade 3). Long-distance metastasis was found in 60% of the cases. Fourteen patients were submitted to wide surgical resections, with local relapse being observed in 11 of them (78.5%). The authors suggest that improved outcome in oral malignant melanoma requires the development of new therapies and the prevention of distant metastasis.

Primary Oral Mucosal Melanomas – Two Case Reports and Comprehensive Literature Review

“…In the review article by Mihajlović et al 36 , data are cited from the American literature that OM are rare tumors with an annual incidence of 0.2 per million, that is, 1 case per 5 million people 37 . Th e authors from South America provide a fi gure of 1.2 OM cases per 10 million 38 . OMs are more common in the Japanese population, accounting for 7.5% of all melanomas.…”

Clinical features of the head and neck mucosal melanoma. А review

“…Более того, 7,5 % всех меланом у японцев развиваются в полости рта (1 % у пациентов европеоидной расы) [25,26]. Уровень заболеваемости у мужчин и женщин, по данным большинства исследований, одинаковый [4,5,[26][27][28][29], но согласно некоторым исследованиям среди мужчин этот показатель несколько выше [1,[30][31][32][33]. По S. Kanetaka и соавт., в Японии соотношение между мужчинами и женщинами составило 3:10 [25].…”

“…Они чаще всего локализуются в области верхних дыха-тельных и пищеварительных путей, а именно -в око-лоносовых пазухах и полости рта [3][4][5].…”

“…Они чаще всего локализуются в области верхних дыха-тельных и пищеварительных путей, а именно -в око-лоносовых пазухах и полости рта [3][4][5].Первичные МСО головы и шеи (МСОГШ) состав-ляют около 0,7-3,8 % всех меланом и локализуются (в убывающем порядке по частоте встречаемости) в околоносовых пазухах, полости рта, глотке, гортани и верхней трети пищевода [2,[4][5][6]. МСОГШ ассоции-руются с плохим клиническим исходом и обладают высоким метастатическим потенциалом, 5-летняя без-рецидивная выживаемость составляет от 0 до 20 % [8][9][10][11].…”

A Study on Malignant Melanoma

“…The malignant melanoma in intestine mostly occurs in oropharynx and nasopharynx constitutes about 32.8% and in small intestine constitutes about2.3%. The first case of maliganant melanoma was described in 1885 in literature, and high localization was found in maxillary gingival, hard palate, alveolar ridge (Hashemi et al, 2009;Aguas et al, 2009;Lourenco et al, 2009;.…”