Primary Orbital Melanoma Associated With an Occult Episcleral Nevus

Mandeville, John; Grove, Arthur S.; Dadras, Soheil S.; Zembowicz, Artur

doi:10.1001/archopht.122.2.287

Cited by 15 publications

(4 citation statements)

References 7 publications

(13 reference statements)

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“…Doctors involved in the treatment of nevus of Ota (as in our case, ophthalmologists, pathologists, dermatologists, brain surgeons, otolaryngologists, radiologists, and dentists) should understand that malignant transformation could occur and should cooperate with one another for its treatment. Although practical strict prognostic indicators for orbital melanoma are yet to be established 3, this particular case suggests that the characteristic indolent progression of the animal-type melanoma might partly contribute toward the good prognosis.…”

Section: Discussionmentioning

confidence: 94%

“…Malignant transformations are rarely observed in the orbit 1 and seldom seen among Asians 2. As the potential for local invasion or metastasis varies widely, strict prognostic indicators for orbital melanoma have yet to be established 3. Animal-type melanoma is a rare type of malignant melanoma that usually arises in skin lesions 4 and shows indolent progression and good prognosis despite metastasis.…”

Section: Introductionmentioning

confidence: 99%

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Animal-type malignant melanoma associated with nevus of Ota in the orbit of a Japanese woman

Nitta¹,

Kashima²,

Mayuzumi³

et al. 2014

Melanoma Research

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We present a patient with an animal-type malignant melanoma associated with the nevus of Ota in the orbit who showed a good prognosis after a combination of orbital extirpation, chemotherapy, stereotactic radiotherapy, and gamma knife. A 42-year-old Japanese woman presented with two tumors, one pathologically diagnosed as right-sided intraconal animal-type malignant melanoma and the other intracranially, presumed to be of the same pathogenesis and both were considered to have arisen from the nevus of Ota. She underwent an extirpation of the orbit, chemotherapy (DAV therapy, which is a combination of dacarbazine, nimustine, and vincristine), stereotactic radiotherapy (54 Gy in 27 fractions), and gamma knife (marginal dose was 17 Gy, target volume was 0.2 ml). She has been alive for 33 months since the extirpation, with no sign of local recurrence, new metastasis, nor enlargement of the intracranial tumor. Not just combination therapy but also the low malignancy of animal-type melanoma may have contributed toward the good prognosis.

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Animal-type malignant melanoma associated with nevus of Ota in the orbit of a Japanese woman

Nitta¹,

Kashima²,

Mayuzumi³

et al. 2014

Melanoma Research

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“…Epidemiology: Primary or secondary orbital melanomas are extremely rare tumors; they represent less than 1% of primary orbital neoplasms. Over 90% of primary orbital melanomas arise from melanocytes (congenital ocular melanosis, oculodermal melanosis) [13].…”

Section: Orbital Melanomasmentioning

confidence: 99%

Pigmented Epibulbar Lesions: Overview

Furdová¹,

Jameel²,

Ivana³

et al. 2014

Pigmentary Disorders

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Eyes can be affected by a wide variety of epibulbar lesions. The incidence and prevalence of the epibulbar lesions is significantly high, with an incidence of 89.8% of the benign lesions as compared to the malignant lesions that accounted for 10.2% of the lesions. Considering the significance of the knowledge of the different types of epibulbar lesions, there is a need to perform a brief discussion of these lesions to develop the information of these lesions among the general population and the healthcare professionals. This would enable the successful diagnosis of the different types of epibulbar lesions. Epibulbar pigmented lesions include conjunctival epithelial melanosis, conjunctival freckle, primary acquired melanosis, conjunctival nevus, congenital ocular melanocytosis, and malignant melanoma. Jou rn a l o f Pi gmentary D is o rd ers

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“…POM has been diagnosed in all ages from the pediatric population to the elderly, with or without congenital anomalies, and with both indolent as well as extremely aggressive disease courses. [12][13][14][15][16][17][18] The treatment approaches include some combination of surgery, such as orbital exenteration or debulking, radiation, and chemotherapy. However, the choice of orbital exenteration for POM is grounded in observation from uveal melanoma and survival benefits between possible treatment sequences has only recently been explored.…”

Section: Introductionmentioning

confidence: 99%

Primary Orbital Melanoma: An Investigation of a Rare Malignancy Using the National Cancer Database

et al. 2021

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Objectives: Primary orbital melanoma (POM) is a rare disease with limited data on survival and best treatment practices.Here we utilize the National Cancer Database (NCDB) to determine the overall survival (OS) and covariates that influence mortality.Study Design: Retrospective cohort study.Methods: All patients diagnosed with POM from 2004 to 2016 were identified in the NCDB. Patient and oncologic data were analyzed using the Kaplan-Meier method and multivariate models for the primary outcome of OS.Results: A total of 129 patients were identified. Median OS was 36.9 months (95% confidence interval [CI] 24.1-78.7months) with mean 5-year survival of 42.0% (CI 33.2%-53.2%). Treatments received included surgery alone (43.4%), radiation alone (23.3%), and surgery followed by radiation (20.2%). The multivariate model demonstrated an increased risk of death associated with age over 80 years (hazard ratio [

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Primary Orbital Melanoma Associated With an Occult Episcleral Nevus

Abstract: I-II study of isolated hepatic perfusion using melphalan with or without tumor necrosis factor for patients with ocular melanoma metastatic to liver.

Cited by 15 publications

References 7 publications

Animal-type malignant melanoma associated with nevus of Ota in the orbit of a Japanese woman

Animal-type malignant melanoma associated with nevus of Ota in the orbit of a Japanese woman

Pigmented Epibulbar Lesions: Overview

Primary Orbital Melanoma: An Investigation of a Rare Malignancy Using the National Cancer Database

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