2021
DOI: 10.1016/j.ajpath.2021.05.016
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Primary Osteoarthritis Early Joint Degeneration Induced by Endoplasmic Reticulum Stress Is Mitigated by Resveratrol

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Cited by 21 publications
(28 citation statements)
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“…It has been reported that endoplasmic reticulum oxidative stress occurs in articular chondrocytes of OA patients, which promotes apoptosis of chondrocytes ( Bian et al, 2018 ), ( Cao et al, 2018 ). After treatment with antioxidants, they can protect the chondrocytes, thus alleviating disease ( Fu et al, 2022 ), ( Hecht et al, 2021 ), ( Lin et al, 2021 ). Therefore, we conducted a further study on the causes of endoplasmic reticulum stress.…”
Section: Resultsmentioning
confidence: 99%
“…It has been reported that endoplasmic reticulum oxidative stress occurs in articular chondrocytes of OA patients, which promotes apoptosis of chondrocytes ( Bian et al, 2018 ), ( Cao et al, 2018 ). After treatment with antioxidants, they can protect the chondrocytes, thus alleviating disease ( Fu et al, 2022 ), ( Hecht et al, 2021 ), ( Lin et al, 2021 ). Therefore, we conducted a further study on the causes of endoplasmic reticulum stress.…”
Section: Resultsmentioning
confidence: 99%
“…The most recent development is the I-ERS mouse, in which ER stress is generated by the expression of mutant cartilage oligomeric matrix protein (COMP) as a misfolded protein in adult articular chondrocytes to simulate non-trauma-induced, age-dependent OA. In this mouse model, ER stress-induced osteoarthritic damage occurred slowly, closely mimicking cartilage degeneration in the elderly [ 34 ].…”
Section: Discussionmentioning
confidence: 99%
“…Notably, IRE1α plays a key role in chondrocyte proliferation, ECM production, etc 42 ., which indicates the regulatory function of IRE1α-mediated ER stress in chondrocyte proliferation and degeneration. Jacqueline et al 43 found that the two top risk factors for OA, age and obesity, were highly associated with ER stress, and resveratrol mitigated early joint degeneration by inhibiting ER stress. Benedetta et al 44 found that chronic ER stress decreased chondrocyte proliferation.…”
Section: Discussionmentioning
confidence: 99%