Primary osteogenic sarcoma of the breast: A case report

Abstract

Introduction: Primary osteosarcoma of the breast is a rare malignant tumour. It is typically a poor prognosis tumour, which has some interesting features worthy of discussion. We report a case of primary osteosarcoma of the breast and summarise the previous medical literature to highlight several details of this unusual tumour.

Osteosarcoma Breast - A Case Report

“…So lymph node dissection is not needed. [19] Prognostic factors for primary osteosarcomas of the breast include tumor size, number of mitoses, and presence of stromal atypia. [20] There is little evidence on the long-term prognosis of the disease due to the small number of cases reported in the literature.…”

Primary Osteosarcoma of the Breast- A Case Report and Review of Literature

“…The true incidence of the primary breast sarcomas is difficult to estimate. It is less than 0.1% [1][2][3] of all primary breast malignancies. The annual incidence of primary breast sarcoma is estimated to be around 45 new cases per 10 million women [4].…”

“…It has been suggested to arise from mesenchymal cells de novo or transformation of a fibroadenoma or phylloides tumour [1,6]. Its association with fibroadenoma or phylloides tumor can be partly explained by the fact that the earlier series included various histopathology types due to a lack of consensus [6,9].…”

“…Fewer than 150 cases have been described in the literature over the past 50 years [1]. Many of the cases are described in association with a biphasic tumor i.e fibro adenoma, phylloides tumor or carcinosarcoma [2].…”

Primary breast osteosarcoma: a case report and review of literature

“…Overall, there is no clear role for adjuvant chemoradiotherapy, but factors like the tumour site/size/ staging, patients' preference and fitness, and the clearance of the surgical margins may all play a role in this prospect. 8,12,13,[17][18][19][20][21][22] Conclusion PBO is a rare breast malignancy that affects elderly patients. Diagnosis is often challenging and can be debatable due to its rarity, non-specific radiological findings and the complicated histopathological subtypes.…”