Primary osteosarcoma of the breast

Abstract

We report a case of primary osteosarcoma of the breast, which is a rare histological type of all breast tumors. A 58-year-old woman had noticed a right breast mass long before presenting to our hospital because it had gradually increased in size. The mass was bony-hard, 90 x 70 mm in size, and was located mainly in the upper outer quadrant of the left breast. Mammography demonstrated a round radiopaque mass with a shaggy outline. There were small bone metastases to the pelvis and scapula on bone radionuclide scan, but no other metastasis was observed with subsequent investigations. Modified radical mastectomy including axillary lymph node dissection was performed. Histologically, the excised tumor was consistent with extraskeletal osteosarcoma of the breast accompanied by lymph node metastses. In spite of adjuvant chemotherapy, the patient suffered a local recurrence four months later and died of aggressive multiple metastases 7 months after surgery.

Primary Osteosarcoma of Breast, A Rare Case.

“…In addition, the diagnosis of a primary breast osteosarcoma, which is similar to those of other extra skeletal tumours, requires the absence of a direct connection between the tumour and the underlying skeleton [7,8]. In similarity to the above observation, no connetion was noted with the overlying bony ribs in this case.…”

Primary osteogenic sarcoma of the breast

“…Clinically, the breast lump is of varying consistency and may be rapidly growing. At the time of presentation, most patients have developed metastasis in different parts of the body including the chest and bones, though this was not the case with our patient [18]. The two patients from our centre – this case and the earlier reported one [11] – presented for definitive treatment about one year after noticing breast lumps and when the tumors were already locally advanced.…”

Primary osteosarcoma of the breast: A case report

“…Usually, it is without bloody leakage from the nipple and axillary lymph node enlargement (1,5–8,11,13–15). The presence of palpable enlarged axillary lymph nodes on the side of the tumour has only been reported in two primary breast OS cases (4,12). Similar to the radiology examinations of the current patient, in mammography imaging, OS presents as a well-circumscribed, oval and firm calcified mass (6–8,11–15).…”

“…A lymphadenectomy in patients with OS is justified in situations where axillary lymphadenopathy is observed. In such cases, palpable, enlarged lymph nodes may be the site of neoplastic metastases (4,12). In the present case, the simple mastectomy was performed as no enlarged lymph nodes were observed during the physical examination.…”