Primary osteosarcoma of the kidney

Axelrod, Rita; Naidech, Howard; Myers, Jeffrey; Steinberg, Allen J.

doi:10.1002/1097-0142(197802)41:2<724::aid-cncr2820410244>3.0.co;2-n

Cited by 28 publications

(15 citation statements)

References 6 publications

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“…The presence of osteoid/bone matrix in both examples of renal SEF presented herein raises the differential diagnosis of renal osteosarcoma. Renal osteosarcoma is rare 44, 45 , and it is possible that some of the cases reported could represent incompletely-sampled sarcomatoid carcinomas. Of note, like the cases of renal SEF reported herein, cases of primary renal osteosarcoma have tended to present at advanced stage.…”

Section: Discussionmentioning

confidence: 99%

Primary Renal Sclerosing Epithelioid Fibrosarcoma

Argani

Lewin

Edmonds³

et al. 2015

American Journal of Surgical Pathology

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We report the first two genetically confirmed cases of primary renal sclerosing epithelioid fibrosarcoma (SEF), occurring in a 17 year-old male and a 61 year-old female. In both cases, the tumors demonstrated the typical epithelioid clear cell morphology associated with extensive hyalinizing fibrosis, raising the differential diagnosis of solitary fibrous tumor, metanephric stromal tumor, and the sclerosing variant of clear cell sarcoma of the kidney. Both neoplasms demonstrated diffuse immunoreactivity for MUC4, a highly specific marker for SEF, and both demonstrated evidence of rearrangement of both the EWSR1 and CREB3L1 genes which have recently shown to be fused in this entity. Both neoplasms presented with metastatic disease. Primary renal SEF represents yet another translocation-associated sarcoma now shown to arise primarily in the kidney.

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Section: Discussionmentioning

confidence: 99%

Primary Renal Sclerosing Epithelioid Fibrosarcoma

Argani

Lewin

Edmonds³

et al. 2015

American Journal of Surgical Pathology

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“…Il semble que la radiothérapie soit plus efficace dans les ostéosar-comes extra-squelettiques que dans les atteintes squelettiques. La chimiothérapie utilisée fait appel aux mêmes médicaments que ceux utilisés dans les ostéosarcomes des os [13][14][15][16] .…”

Section: Discussionunclassified

Ostéosarcome primitif du rein avec évolution métastatique au foie.Étude de cas et revue de la littérature

Gharbi

Trabelsi

Hochlef

et al. 2013

CUAJ

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L’ostéosarcome primitif du rein est une pathologie très rare dontl’histogénèse n’est pas claire. Les récidives locales et les métastasessont fréquentes et le pronostic est très mauvais. Nous décrivons icile cas d’une patiente de 59 ans qui présentait des douleurs lombairesgauches et un amaigrissement. Une échographie abdominaleet une tomodensitométrie abdominale ont révélé une masserétropéritonéale de 13 × 8 × 9 cm avec macrocalcifications. Lebilan d’extension n’a pas révélé d’autres lésions. On a procédé àune néphrectomie élargie gauche; l’examen histologique a révéléune prolifération tumorale constituée de cellules fusiformes de taillevariable, ces cellules manifestement atypiques produisant directementdu tissu ostéoïde évoquant un ostéosarcome rénal. Dix moisplus tard, la patiente présentait des lésions métastatiques au niveauhépatique sans autre lésion secondaire ni récidive locale. La patienteest actuellement en cours de traitement par chimiothérapie pardoxorubicine et cisplatine avec un recul de 17 mois. Les caractéristiquesanatomocliniques et les modalités thérapeutiques decette pathologie rare sont discutées ci-dessous.Primary osteosarcoma of the kidney is very rare. Its exact histogenesisremains unclear. It has a tendency to recur locally and metastasize,and the prognosis is very poor. We present a case of a59-year-old woman with left flank pain and weight loss. Abdominalultrasonography and bone scan revealed a large solid retroperitonealmass with calcifications. The patient underwent radicalnephrectomy; microscopic examination showed atypical cells withthe characteristic pattern of classic osteosarcoma with immatureneoplastic osteoid. Ten months later, the patient developedmetastatic lesions in the liver, without local recurrence or othersites of metastases. The patient is currently receiving chemotherapywith doxorubicin and cisplatin, with a follow-up in 17 months.The most important clinical findings, the pathogenesis and thetreatment modalities of this rare neoplasm are discussed.

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“…Extraskeletal osteosarcoma is a rare entity and case descriptions can be found throughout the literature mostly in the limbs and limb girdles 3. Even fewer are reports of parenchymal osteosarcoma, but such cases have been documented in thyroid, kidney, gallbladder, breast, mesentery, liver, and colon 4–10…”

Section: Discussionmentioning

confidence: 99%