Primary Osteosarcoma of the Uterus: Report of a Case with Immunohistochemical Analysis

Emoto, Makoto; Iwasaki, Hiroshi; Kawarabayashi, Tatsuhiko; Egami, Daisuke; Yoshitake, Hidenori; Kikuchi, Masahiro; Shirakawa, K

doi:10.1006/gyno.1994.1229

Cited by 21 publications

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“…Distinction between metaplasia in a malignant mesenchymal tumour and divergent mesenchymal stem cell differentiation is interpretative and not necessarily exclusive. Reasoning along the same lines stated above, it seems likely that some of the reported uterine osteosarcomas may have arisen directly from mesenchymal stem cells without a benign precursor as has been suggested by other authors 20 , 23 , 24 …”

Section: Discussionmentioning

confidence: 66%

“…Furthermore, examples of leiomyomas with skeletal muscle differentiation and uterine rhabdomyosarcoma have been reported 15 –18 . To the best of our knowledge this is the nineteenth case of osteosarcoma in the myometrium described in the English language 19 –22 . However, this case is unique, as none of the previously reported osteosarcomas was noted to arise in a leiomyoma.…”

Section: Discussionmentioning

confidence: 83%

“…Current views on the histogenesis of primary uterine osteosarcoma include: (i) osteosarcoma as part of a malignant mixed mesodermal (müllerian) tumour (MMMT); (ii) osteosarcoma as a pure heterologous stromal sarcoma; (iii) malignant transformation of benign osseous metaplasia in leiomyoma; and (iv) derivation from primitive mesodermal cells with monomorphic development 20 , 23 –25 . Histological and immunohistochemical evidence of epithelial differentiation was not observed in our case, arguing strongly against MMMT, while a pedunculated malignant tumour connected to the fundus by a stalk of benign smooth muscle virtually rules out the possibility of a stromal sarcoma.…”

Section: Discussionmentioning

confidence: 99%

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Malignant mesenchymoma of the uterus, arising in a leiomyoma

et al. 2002

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Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

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Malignant mesenchymoma of the uterus, arising in a leiomyoma

et al. 2002

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“…While MMMTs grow as polypoid masses towards the inside of the endometrial cavity, pure heterologous sarcomas generally grow as an intramural mass that compress the endometrium (9,(11)(12)(13). In our case, tumor infiltrated the myometrium and grew as an intramural mass.…”

Section: Discussionmentioning

confidence: 99%

Primary Chondroblastic Osteosarcoma of the Uterus: Immunohistochemical Examination and Differential Diagnosis with Malignant Mixed Mullerian Tumor

Özyalvaçlı¹,

Behzatoğlu²,

Astarci³

et al. 2015

Istanbul Med J

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Extraskeletal osteosarcomas are rarely observed tumors. Besides this, primary osteosarcomas of uterus are rarer, and only 21 cases have been reported in the literature. It is generally seen at the postmenopausal period, and it progresses quite aggressively. Particularly, malignant mixed mullerian tumors (MMMTs) are important for differential diagnosis. Histopathological and immunohistochemical examination of a mass that was detected in the uterus of a 61-year-old postmenopausal patient revealed the diagnosis of primary chondroblastic osteosarcoma, and this very rare case is presented here.

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“…169 OSTEOSARCOMA Uterine neoplasms displaying osseous differentiation are most commonly malignant mixed Mu¨llerian tumors. However, 19 osteosarcomas without a clearly demonstrable epithelial component have been reported, [170][171][172][173][174][175][176][177][178][179][180][181][182][183][184][185][186][187][188] in women ranging in age from 41 to 82 years (median 62 y; Table 6). Osteosarcomas of the uterus are highly aggressive neoplasms, and the calculated median survival for these 123 50…”

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confidence: 99%

Heterologous and Rare Homologous Sarcomas of the Uterine Corpus

Fadare¹

2011

Advances in Anatomic Pathology

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Pure sarcomas of the uterine corpus are uncommon, constituting less than 3% of all malignancies at this site, and most of them are leiomyosarcomas and endometrial stromal sarcomas. Rare histotypes of homologous sarcomas and heterologous sarcomas are occasionally encountered, and the absence of significant accumulated experience with these histotypes at this location may potentially raise diagnostic and patient management difficulties. In this article, the clinicopathologic attributes of all earlier reported sarcomas of the uterine corpus other than leiomyosarcomas and endometrial stromal sarcomas are summarized. Included are embryonal rhabdomyosarcoma, pleomorphic rhabdomyosarcoma, angiosarcoma, alveolar soft part sarcoma, malignant perivascular epithelioid cell tumors (PEComas), osteosarcoma, chondrosarcoma, liposarcomatous tumors, malignant extrarenal rhabdoid tumors, Ewing sarcoma/primitive neuroectodermal tumor, and other rare histotypes. Embryonal rhabdomyosarcoma (20%), Ewing sarcoma/primitive neuroectodermal tumor (17%), angiosarcoma (14%), and pleomorphic rhabdomyosarcoma (13%) appeared to be more common than the others, although there was no single overwhelmingly prevalent histotype in the group. A subset, including embryonal rhabdomyosarcoma, alveolar soft part sarcoma, and PEComas, peak in the premenopausal years, but most of the others were observed in postmenopausal women. Favorable outcomes have been reported for the patients diagnosed with alveolar soft part sarcoma, and the prognosis for their counterparts with PEComa remains a matter of debate. Multimodal therapeutic approaches to contemporary patients with embryonal rhabdomyosarcomas have resulted in significantly improved outcomes. Unfortunately, most of the other sarcomas have been associated with rapid tumor progression and unfavorable patient outcomes. The differential diagnosis for these sarcomas is often extensive and varies by histotype, but their accurate diagnosis fundamentally requires the careful exclusion of biphasic malignancies.

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Primary Osteosarcoma of the Uterus: Report of a Case with Immunohistochemical Analysis

Cited by 21 publications

References 0 publications

Malignant mesenchymoma of the uterus, arising in a leiomyoma

Malignant mesenchymoma of the uterus, arising in a leiomyoma

Primary Chondroblastic Osteosarcoma of the Uterus: Immunohistochemical Examination and Differential Diagnosis with Malignant Mixed Mullerian Tumor

Heterologous and Rare Homologous Sarcomas of the Uterine Corpus

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