Primary otological manifestations of granulomatosis with polyangiitis: a case series

Amiraraghi, Natasha; Robertson, Scott; Iyer, Arunachalam

doi:10.1017/s0022215114002527

Cited by 5 publications

(8 citation statements)

References 11 publications

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“… 1 – 4 American College of Rheumatology, American Society of Nephrology and the European League Against Rheumatism suggested that the name should be changed to GPA. 7 , 8 …”

Section: Discussionmentioning

confidence: 99%

“…However, c-ANCA can also be associated with other diseases, especially with rheumatoid arthritis. 1 , 2 , 7 , 8 Therefore, some cases of GPA are negative for c-ANCA. A positive identification of c-ANCA is suggestive of GPA, but cannot replace a biopsy.…”

Section: Discussionmentioning

confidence: 99%

“…Nasal obstruction, crusts and purulent and bloody discharge, facial pain, nasal septum perforation, and progressive nose deformity are the most frequent initial manifestations of GPA. 7 ENT involvement is a common feature in ANCA-associated vasculitis (AAV), particularly in GPA. Otologic manifestations in GPA are common, occurring in 20%–70% of the cases and representing the second most frequent symptoms of head and neck involvement.…”

Section: Discussionmentioning

confidence: 99%

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Otitis media with effusion as an initial manifestation of granulomatosis with polyangiitis

Djerić

Perić

Pavlović

et al. 2021

SAGE Open Medical Case Reports

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Granulomatosis with polyangiitis is a systemic vasculitis of unknown etiology, characterized by necrotizing granulomas. It is an autoimmune disease affecting small- and medium-sized vessels of upper and lower respiratory tract, kidneys, and other organs. We described a case of a patient with otitis media with effusion as the first manifestations of granulomatosis with polyangiitis. A 54-year-old female presented as an urgent case with history of a severe otalgia, hearing loss, vertigo, and fever. The patient was treated with diagnosis of otitis media with effusion and acute rhinosinusitis, but without significant success. She developed an acute kidney dysfunction as a sign of glomerulonephritis with rapidly progressive renal failure. Diagnosis of granulomatosis with polyangiitis was confirmed after the histopathological analysis of kidney tissue, not by analysis of middle ear and paranasal sinus mucosa specimens. The patient was treated according to generally accepted protocol, and over time, there was an almost complete recovery.

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“… 1 – 4 American College of Rheumatology, American Society of Nephrology and the European League Against Rheumatism suggested that the name should be changed to GPA. 7 , 8 …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Otitis media with effusion as an initial manifestation of granulomatosis with polyangiitis

Djerić

Perić

Pavlović

et al. 2021

SAGE Open Medical Case Reports

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“…In der Konsequenz ist insbesondere bei der bilateralen, rezidivierenden oder protrahierten Otitis media an eine autoimmunologische Erkrankung zu denken und nach c-ANCA zu suchen. Chirurgische Maßnahmen sind bei der Granulomatose mit Polyangiitis aufgrund des Risikos von protrahierten Heilungsverläufen zurückhaltend zu stellen [113].…”

Section: Granulomatose Mit Polyangiitisunclassified

“…Consequently, especially in bilateral, recurrent or protracted otitis media, an autoimmunological disease should be considered and c-ANCA should be sought. Surgical treatment should be carefully indicated in granulomatosis with polyangiitis due to the risk of protracted healing [113].…”

Section: Letterer-siwe Syndromementioning

confidence: 99%

Seltene Erkrankungen des Mittelohres und der lateralen Schädelbasis

Weiss

2021

Laryngorhinootologie

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ZusammenfassungOtalgie, Otorrhoe, Tinnitus und Hörminderung zählen zu den häufigsten ohrbezogenen Symptomen, die zum Aufsuchen eines Hals-Nasen-Ohrenarztes führen. Weiterhin spielen Gleichgewichtsstörungen und Affektionen der Hirnnervenfunktion für eine Konsultation eine Rolle. In großen akademischen Zentren, aber auch in der HNO-ärztlichen Grundversorgung kommt der Erkennung von seltenen Erkrankungen des Mittelohres und der lateralen Schädelbasis eine zentrale Rolle zu, da sie häufig eine interdisziplinäre Zusammenarbeit erfordern um die korrekte Diagnose zu stellen und eine adäquate Behandlung zu initiieren. Die folgende Arbeit gibt einerseits eine Übersicht über seltene Formen von osteologischen, neoplastischen, hämatologischen, autoimmunologischen und infektiologischen Erkrankungen sowie Fehlbildungen, die sich im Mittelohr und der lateralen Schädelbasis manifestieren können, andererseits soll ein Überblick über internistische Erkrankungen gegeben werden, deren Manifestation im Mittelohr selten ist. Die Kenntnis von seltenen Erkrankungen des Mittelohrs und der Schädelbasis ist für die Qualitätssicherung in der Patientenversorgung und insbesondere auch bei entsprechenden chirurgischen Maßnahmen wesentlich. Insbesondere bei untypischen, komplizierten und langwierigeren Krankheitsverläufen muss an seltene Differenzialdiagnosen gedacht werden.

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Granulomatosis with polyangiitis and facial palsy: Literature review and insight in the autoimmune pathogenesis

Iannella

Greco

Granata

et al. 2016

Autoimmunity Reviews

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Primary otological manifestations of granulomatosis with polyangiitis: a case series

Cited by 5 publications

References 11 publications

Otitis media with effusion as an initial manifestation of granulomatosis with polyangiitis

Otitis media with effusion as an initial manifestation of granulomatosis with polyangiitis

Seltene Erkrankungen des Mittelohres und der lateralen Schädelbasis

Granulomatosis with polyangiitis and facial palsy: Literature review and insight in the autoimmune pathogenesis

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