Primary Ovarian Lymphoma: A Case Report and Review of Literature

Kumar, Narendra; Kumar, Ritesh; Bera, Anjan; Srinivasan, Radhika; Sharma, Suresh C.

doi:10.1007/s13224-012-0200-6

Cited by 16 publications

(14 citation statements)

References 7 publications

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“…Las neoplasias pueden ser microscópicas o muy grandes y generalmente son unilaterales (5) . Algunos casos presentan ascitis y concentraciones séricas elevadas de CA-125.…”

Section: Discussionunclassified

“…El linfoma de ovario y los linfomas extraováricos parecen similares desde el punto de vista histopatológico, excepto que en el primero las células tumorales se adhieren a la reticulina y forman pseudoacinos, por lo que tienen tendencia a crecer en cuerdas o nidos (5) . El disgerminoma muestra positividad a la fosfatasa alcalina placentaria y CD117 mientras que las células tumorales de la granulosa son positivas a inhibina y calretinina.…”

Section: Discussionunclassified

“…Tanto el estadio clínico como la modalidad e índice pronóstico internacional también pueden ser utilizados como factores pronósticos útiles (5) . El tipo histológico es probablemente uno de los factores pronósticos más importantes, ya que los linfomas de células B están asociados con mayor supervivencia (2) .…”

Section: Discussionunclassified

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Linfoma no Hodgkin primario de ovario. Reporte de caso

Pérez-Ortiz

2018

Rev peru ginecol obstet.

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Declaración de aspectos éticosReconocimiento de autoría: Todos los autores declaran que han realizado aportes a la idea, diseño del estudio, recolección de datos, análisis e interpretación de datos, revisión crítica del contenido intelectual y aprobación final del manuscrito que estamos enviando.Responsabilidades éticas: Protección de personas. Los autores declaran que los procedimientos seguidos se conformaron a las normas éticas del comité de experimentación humana responsable y de acuerdo con la Asociación Médica Mundial y la Declaración de Helsinki. Confidencialidad de los datos:Los autores declaran que han seguido los protocolos del Hospital Central "Dr. Urquinaona" y Universidad Técnica de Manabí sobre la publicación de datos de pacientes.Derecho a la privacidad y consentimiento informado: Los autores han obtenido el consentimiento informado de los pacientes y/o sujetos referidos en el artículo. Este documento obra en poder del autor de correspondencia.Financiamiento: Los autores certifican que no han recibido apoyos financieros, equipos, en personal de trabajo o en especie de personas, instituciones públicas y/o privadas para la realización del estudio, Conflicto de intereses: Los autores declaran RESUMENLos linfomas ováricos son raros. Aquel que se presenta como una masa pélvica con manifestación inicial es aun más raro. El diagnóstico impreciso o tardío se debe a menudo a las lesiones que se presentan similares al cáncer de ovario y puede conducir a un desenlace desfavorable. Presentamos el caso de mujer de 48 años con dolor abdominal. La ecografía y tomografía computada preoperatoria mostraron tumor quístico heterogéneo. La laparotomía reveló tumoración anexial izquierda de origen ovárico. Se realizó histerectomía total, ooforo-salpingectomía bilateral y omentectomía parcial. No se encontró evidencia de que la lesión se hubiese propagado más allá del ovario. El diagnóstico de linfoma no Hodking del tipo difuso de células B grandes difusas del ovario se realizó mediante examen histopatológico junto con inmunohistoquímica del tejido extirpado. El paciente recibió seis ciclos de quimioterapia. Después de 18 meses de seguimiento, la paciente continúa libre de enfermedad. Palabras clave. Linfoma ovárico primario, Tumor ovárico, Linfoma no Hodgkin.ABSTRACT Ovarian lymphomas are rare. Those presenting as a pelvic mass with initial manifestations are even rarer. Inaccurate or delayed diagnosis is often due to lesions resembling ovarian cancer and may lead to a poor outcome. We report the case of a 48-year-old female presenting with abdominal pain. Preoperative ultrasound and computed tomography showed a heterogeneous cystic mass. Laparotomy revealed a right adnexal mass of ovarian origin. Total hysterectomy, bilateral oophoro-salpingectomy, and partial omentectomy were performed. There was no evidence that the tumor had spread beyond the ovary. The diagnosis of primary nonHodgkin lymphoma of the ovary was done by histopathological examination along with immunohistochemistry of the excised tissue. The patient ...

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“…Las neoplasias pueden ser microscópicas o muy grandes y generalmente son unilaterales (5) . Algunos casos presentan ascitis y concentraciones séricas elevadas de CA-125.…”

Section: Discussionunclassified

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Linfoma no Hodgkin primario de ovario. Reporte de caso

Pérez-Ortiz

2018

Rev peru ginecol obstet.

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“…This distinction between primary and secondary lymphomas was usually made postoperatively, when the diagnosis of ovarian lymphoma was established and when its extension was evaluated. In this study the sure diagnosis was made postoperative as the preliminary diagnosis was usually an ovarian carcinoma [16].…”

Section: Ivac (Cycles Two and Four)mentioning

confidence: 99%

Primary Ovarian Non-Hodgkin’s Lymphoma: Retrospective Study of 16 Patients

Aziz¹,

Fathalla²,

Sidhom³

2016

JCT

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Background: Primary non-Hodgkin's lymphoma (PONHL) of the ovary is rare disease. Ovarian involvement by NHL is usually secondary, as a part of systemic disease. It is frequently diagnosed as ovarian carcinoma which causes a significant delay in diagnosis and management. Objective: To analyze, to report and to better understand the clinico-pathologic features and results of treatment, and prognostic factors of these tumors. Material & methods: This was a retrospective single institutional work that included 16 cases of primary ovarian non-Hodgkin lymphoma (PONHL) treated in National Cancer Institute-Cairo University from January 2010 till January 2015. All available medical data including the clinical and pathological characteristics, treatment, and outcomes of patients with PONHL are analyzed. Results: Data from 16 patients are obtained. The patient's age ranges from 14 to 55 years (mean 28 years). Ascites is the most common manifestation (75%). Tumor size ranges from 5 to 24 cm (mean 13.1). LDH is elevated in all cases (mean 644 U/L) and CA-125 is elevated in only 4 cases (25%) especially when there is an extensive peritoneal irritation. Ten cases (62.5%) are bilateral with stage IV-E according to the Ann Arbor staging system. The remaining six cases (37.5%) are unilateral with Ann Arbor stage I-E. There are no stage II-E or III-E in the current study. Tumors are classified according to the World Health Organization as follows: diffuse large B-cell lymphoma (10 cases) (62.5%), Burkitt's lymphoma (5 cases) (31%) and only one case of B-lymphoblastic lymphoma/leukemia. All the tumors are of B-cell lineage and are all CD20 positive. All Burkitt's lymphoma cases show higher Ki67 index (4 cases are 100% and one is 88%). The case of B-lymphoblastic lymphoma/leukemia is positive for TDT & CD 10. Surgery is the main treatment modality for primary diagnosis and for staging, although chemotherapy should have been the primary treatment because it is one of the most chemosensitive tumors. Follow-up period ranges from 3 months to 5 years (mean 33 months). Ten patients are alive without disease. Two cases experienced relapse and one case died during chemotherapy treatment. The remaining three cases died from other causes than disease. The median overall sur-* Corresponding author. H. A. Shokralla et al. 56vival time was not reached yet; however, the mean overall survival was 46.8 monthes; median progression free survival was 36 months. Conclusion: Most patients with PONHL present with symptoms attributable to an ovarian mass which necessitates extensive surgical staging that is not mandatory for lymphomas. More studies will be needed to better define and treat this rare entity.

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“…Involvement of the ovary by malignant lymphoma can be primary or secondary [1–3]. The difference between primary and secondary lymphomas is important in terms of prognosis [4].…”

Section: Introductionmentioning

confidence: 99%

An atypical presentation of an ovarian lymphoma: a case report

Ekanayake

Punchihewa²,

Wijesinghe

2018

J Med Case Reports

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BackgroundOvarian lymphoma has a varied clinical presentation and rarely presents with heavy menstrual bleeding. It may occur de novo or secondary to systemic disease and macroscopically appear as solid ovarian tumors.Case presentationA 32-year-old Tamil woman presented with heavy menstrual bleeding of 4 months’ duration. On examination she was anemic with no lymphadenopathy. A large immobile pelvic mass and three firm nodules were found involving her vaginal walls. Ultrasonography suggested a fibroid uterus with two large pedunculated fibroids. Following preoperative optimization an endometrial sampling and biopsy of the nodules were done. Subsequently, histology revealed proliferative phase endometrium. The vaginal nodules showed lymphoid tissue.She presented a week later with an undulating fever and features of acute abdomen with clinical evidence of ascites. During an emergency laparotomy two large solid ovarian masses, gross ascites, pelvic lymph nodes, para-aortic lymph nodes, mesenteric lymph nodes, omental deposits, and a 24-week-size uterus were found. Bilateral oophorectomy was done. Laboratory investigations revealed raised lactate dehydrogenase with normal serum β-human chorionic gonadotropin, alpha-fetoprotein, and cancer antigen-125 levels. Histology of ovarian specimens revealed a diffuse large B cell lymphoma.A bone marrow biopsy revealed more than 80% infiltration with lymphoid cells. Two weeks after the laparotomy a computed tomography of her chest, abdomen, and pelvis revealed a pelvic mass, gross ascites, omental deposits, hepatosplenomegaly, and enlarged lymph nodes above and below her diaphragm. Immunohistochemistry confirmed the diagnosis of B cell lymphoblastic lymphoma. She was classified as stage IV E non-Hodgkin’s lymphoma on the Ann Arbor staging system.ConclusionThis is an atypical presentation of an ovarian lymphoma. The atypical presentations of ovarian lymphomas can lead to diagnostic dilemmas.

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Primary Ovarian Lymphoma: A Case Report and Review of Literature

Cited by 16 publications

References 7 publications

Linfoma no Hodgkin primario de ovario. Reporte de caso

Linfoma no Hodgkin primario de ovario. Reporte de caso

Primary Ovarian Non-Hodgkin’s Lymphoma: Retrospective Study of 16 Patients

An atypical presentation of an ovarian lymphoma: a case report

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