Primary pancreatic lymphoma: what we need to know

Abstract

Hodgkin's lymphoma is a group of malignant lymphoid which involve various organs including gastrointestinal tract. Stomach and small intestine are commonly involved more; however, pancreas can be primarily involved as well. The secondary involvement of pancreas caused by Hodgkin's lymphoma is more prevalent than the primarily involvement (1 .25-2.2% .<1%). Primary pancreatic lymphomas (PPLs) consist of 1-2% of all lymphoma outside nods. The symptoms and findings of PPL imaging can be akin to that of pancreas adenocarcinoma and differentiating them is difficult without examining the tissue sample. The prognosis and treatment of PPL are different from those of adenocarcinoma and due to the superior prognosis of PPL compared to pancreas adenocarcinoma, the proper diagnosis of the disease is important.

Obstructive jaundice as primary presentation of a stage IIE Non-Hodgkin lymphoma: A decision making process between advanced lymphoma and locally advanced/metastatic pancreatic adenocarcinoma

“…At first, the patient had no previous history of malignancy and staging did not reveal a synchronous cancer. Secondly, the present pancreatic mass does not fulfill the criteria of primary pancreatic lymphoma, which are: a) no evidence of palpable superficial lymphadenopathy; b) no enlargement of mediastinal lymph nodes; c) normal leukocyte count; d) dominant pancreatic mass peripancreatic involved lymph nodes; and e) no hepatic or splenic involvement [ 6 ].…”

Primary Pancreatic Diffuse Large B-Cell Lymphoma Involving the Stomach

“…The role of radiotherapy also remains undefined; it is considered an adjuvant to chemotherapy [3]. The majority of patients with PPL receive chemotherapy alone [1,12]. The first-line chemotherapy regimen is prednisolone-vincristine-doxorubicin-cyclophosphamide (CHOP) [12].…”

“…Primary pancreatic lymphoma (PPL) is a rare form of extranodal malignant lymphoma, comprising 1% of all extranodal lymphomas and 0.5% of all pancreatic masses [1,2]. Because PPL and pancreatic adenocarcinoma have similar clinical presentations and imaging findings, histological examinations are needed to differentiate these cancers [2][3][4].…”

Primary pancreatic lymphoma: Clinical presentation, diagnosis, treatment, and outcome

“…6 In most cases, the first manifestation of PPL is abdominal pain; other clinical findings include systemic symptoms such as fever, night sweats, and weight loss; jaundice and/or gastric or duodenal obstruction may also be present. 3,7,8 These heterogeneous symptoms may overlap those of other pancreatic diseases, resulting in diagnostic difficulties. 9,10 PPL can develop in any portion of the gland, but it mainly involves the pancreatic head, which contains the greatest amount of lymphoid tissue.…”

“…11,12 A diagnosis of PPL is usually obtained through percutaneous/endoscopic ultrasoundguided biopsy or exploratory laparotomy biopsy. 7 To the best of our knowledge, reports focused on PPL are limited to few research papers consisting mainly of case reports or collections. 10,[13][14][15] Because of the rarity of this disease, the standardization of a well-defined diagnostic and therapeutic protocol has not yet been developed.…”