Primary pediatric brain tumors

Wong, Tai-Tong; Ho, Donald Ming Tak; Chang, Kuo-Ting; Yen, Sang‐Hue; Guo, Wan-You; Chang, Frank; Liang, Mindy; Pan, Horng‐Bin; Chung, Wen‐Yuh

doi:10.1002/cncr.21430

Cited by 122 publications

(42 citation statements)

References 39 publications

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“…Most of the investigations have stated that craniopharyngiomas rank next to medulloblastomas in their incidence rate [3,4,5, 10,14,15,16,17,18,19,20,21,22,23]. However, in our study, craniopharyngiomas made up approximately 18.4% of brain tumors only after astrocytic tumors.…”

Section: Discussioncontrasting

confidence: 51%

“…Our results indicate that more than half of this tumor type occurred in the 6- to 11-year age group where the highest incidence of high-grade brain tumors of neuroepithelial tissue was observed, but was uncommon in the early and late childhood period. The largest group of primary intracranial GCTs was reported in Japan, Taiwan and far eastern countries with an incidence of 10–14% of the brain tumors [14, 20, 24, 27]. In our analysis, GCTs were most common in the 12- to 14-year age group; in the 9- to 17-year age groups, they comprised 78.6% of all GCT cases.…”

Section: Discussionmentioning

confidence: 72%

“…In different epidemiological investigations, the upper age limit of childhood varied from 14 to 17 years [3,4,5,14,15,16,17,18,19,20,21,22,23] and even to 21 years [2]; therefore, there may be statistical variation. For a detailed comparison with minor bias, we analyzed the data for the 0–14 and 0–17 age group separately.…”

Section: Discussionmentioning

confidence: 99%

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Epidemiology of Nervous System Tumors in Children: A Survey of 1,485 Cases in Beijing Tiantan Hospital from 2001 to 2005

et al. 2008

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Objective: The purpose of the present retrospective study was to describe the epidemiology of nervous system tumors in children based on the clinical data obtained from a neurosurgical center in Beijing. Patients and Methods: During a 5-year period, from January 2001 to December 2005, 1,485 primary brain and spinal tumors in children up to 17 years of age were diagnosed histopathologically according to the World Health Organization 2000 nervous system tumor classification. The sex predilection, tumor location, and histological grade in relation to age were investigated, and the epidemiological characteristics of the 5 most common brain tumors are discussed. Result: Of the 1,485 cases evaluated, brain and spinal tumors comprised 92.3% (1,371) and 7.7% (114), respectively, with a predominance of low-grade tumors (65.1 and 78.9% for brain and spinal cord, respectively). For all tumors, the overall sex ratio (male to female) was 1.6:1. 61.9% of the brain tumors were supratentorial, whereas an infratentorial location was slightly more common in the 872 brain tumors of neuroepithelial tissue (53.7%). The 5 most common brain tumors were astrocytic tumors (30.5%), craniopharyngiomas (18.4%), medulloblastomas (14.6%), germ cell tumors (GCTs, 7.9%) and ependymal tumors (5.6%). The highest preponderance of boys was observed in GCTs followed by medulloblastomas. The most common types of spinal tumors were ependymal tumors (19.3%), neurilemmomas (16.7%) and astrocytomas (14.9%). Conclusions: Based on a large hospital series of pediatric patients, the present survey revealed the histopathological diversity of childhood neurological neoplasms, and provides a reliable profile of the epidemiology of nervous system tumors in children in a developing country.

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Section: Discussioncontrasting

confidence: 51%

Section: Discussionmentioning

confidence: 72%

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Epidemiology of Nervous System Tumors in Children: A Survey of 1,485 Cases in Beijing Tiantan Hospital from 2001 to 2005

et al. 2008

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“…With 100–150 new cases each year in Taiwan, more than 986 cases were treated in TVGH from 1975 to May 2004 19. All patients were treated and followed by the same team, comprised of pediatric neurosurgeons, pathologists, neuroradiologists, pediatric neuro‐oncologists, and radiation oncologists.…”

Section: Methodsmentioning

confidence: 99%

Incidence and long‐term outcome of postradiotherapy moyamoya syndrome in pediatric patients with primary brain tumors: a single institute experience in Taiwan

Chang

Liang

et al. 2016

Cancer Medicine

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We aimed to investigate the incidence and long‐term outcome of moyamoya syndrome in pediatric patients with primary brain tumors after receiving cranial radiotherapy (RT) in a single institute in Taiwan. The complete medical records, medical images, and RT notes of 391 pediatric patients with primary brain tumors treated with cranial RT between January 1975 and December 2005 in Taipei Veterans General Hospital (TVGH), Taiwan, were entered into an electronic registry and reviewed. Eight (2%) cases of post‐RT moyamoya syndrome were identified in the sample of 391 patients. The median latency was 3 years post‐RT. Among the eight patients, three had craniopharyngioma, two had optic glioma, two had medulloblastoma, and one had a suprasellar astrocytoma. The prescribed physical doses of RT were in the range of 40–54 Gy. The incidence was highest in those with optic glioma (0.039/person‐year), followed by craniopharyngioma (0.013/person‐year), astrocytoma (0.003/person‐year), and medulloblastoma (0.002/person‐year). No patients died of vasculopathy. No difference in crude incidence was found between our results and those of other series. The incidence of moyamoya syndrome was diagnosis dependent, with the highest incidence among patients with optic glioma. No regional difference in incidence was found. Long‐term, stable neurological function may be achieved following timely surgical intervention.

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“…This slight prevalence of males over females reflects the gender distribution of the population at risk, the same was found in a Kuwaiti study [13], where male slight preponderance was reported. In another study [14], where the male-tofemale ratio was 1:3, indicated that the pediatric brain tumors were more prevalent in males than in females and other studies found that too [1,15,18].…”

Section: Discussionmentioning

confidence: 93%

Histological types of the primary intracranial tumors among children in Dammam, Saudi Arabia

Alomair¹

2017

IJMDC

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Background: Primary intracranial tumors are the second most common type of pediatric malignancies. Brain tumors account for between 15% and 25% of all childhood malignancies; they have poorer survival rates than hematological malignancies. Intracranial tumors differ throughout childhood stages in their histological types, the location of the tumor and gender distribution. The aim of this study was to investigate the histological types of pediatric brain tumors to gender distribution.

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Primary pediatric brain tumors

Cited by 122 publications

References 39 publications

Epidemiology of Nervous System Tumors in Children: A Survey of 1,485 Cases in Beijing Tiantan Hospital from 2001 to 2005

Epidemiology of Nervous System Tumors in Children: A Survey of 1,485 Cases in Beijing Tiantan Hospital from 2001 to 2005

Incidence and long‐term outcome of postradiotherapy moyamoya syndrome in pediatric patients with primary brain tumors: a single institute experience in Taiwan

Histological types of the primary intracranial tumors among children in Dammam, Saudi Arabia

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