Primary pediatric gastrointestinal lymphoma

Abstract

Background:Primary non-Hodgkin's lymphoma (NHL) of the gastrointestinal (GI) tract is the most common extranodal lymphoma in pediatric age group. Yet, the overall incidence is very low. The rarity of the disease as well as variable clinical presentation prevents early detection when the possibility of cure exists.Materials and Methods:We studied six cases of primary GI NHL in pediatric age group with reference to their clinical presentation, anatomic distribution and histopathologic characteristics.Results:All were males except one. Intestinal obstruction was the presenting feature in 50%. Half the cases showed ileocaecal involvement, while large bowel was involved in 16%. Histology showed four cases of diffuse large B-cell lymphoma (DLBCL), one case of Burkitt lymphoma, and one Burkitt-like lymphoma. Immunohistochemistry for Tdt, CD20, CD3, CD30, bcl2, bcl6 confirmed the morphological diagnosis.Conclusion:Pediatric GI lymphoma commonly involves the ileocaecal region and presents with intestinal obstruction. A higher prevalence of DLBCL is found compared to other series. A high proliferative index is useful in differentiating Burkitt-like lymphoma from DLBCL.

Bowel Obstruction and Perforation in Pediatric Intestinal Mature B Cell Lymphoma: Incidence, Clinical Features, and Outcome in CCHE

“…A higher prevalence of DLBCL is found in pediatric intestinal mature B cell lymphoma compared to other series [4,10]. That is against our finding in CCHE as the higher prevalence of Burkitt's lymphoma is found which account 95.4% of the cases in the overall group, and Burkitt's lymphoma was the pathology of all the subgroup patients.…”

The Role of Ki-67 In Predicting Prognosis And Overall Survival In Pediatric Gastrointestinal Lymphoma

“…This is almost similar to the most of the reported series in the literature. [8,9,10] Abdominal pain was the most common presentation (76.7%) in the present studyfollowed by abdominal swelling (70%), vomiting (40%), intestinal obstruction (20%) and constipation (16.7%). In contrast to most of other studies, none of our patients presented with generalized lymphadenopathy.…”

Gastric Perforation: Unusual Presentation of Gastric Lymphoma in Pediatric Population

“…Primary gastrointestinal (GI) tumors are rare entity in infancy and childhood and accounts for less than 5% of tumors in pediatric age group [1]. Gastrointestinal lymphomas represent 1.0-1.2 % of all pediatric malignancies, and compose 74-82% of GI-related malignancy [2].…”

“…Primary non-Hodgkin's lymphoma of the GI tract is the most common extra nodal lymphoma in pediatric age group; however, most of them are of B-cell origin. T-cell lymphomas of the gastrointestinal tract are rare and most of the reported cases originated in the small intestine [1,3]. The majority of gastrointestinal tumors are non-Hodgkin's lymphoma, however studies on gastric lymphomas in childhood are limited to isolated case reports and most of these cases are Burkitt lymphoma and are associated with Helicobacter pylori infection [4].…”