Primary Percutaneous Coronary Intervention in a Patient with Haemophilia A

Abstract

Haemophilia A is a rare genetic condition leading to coagulation factor VIII deficiency and thus predisposing to bleeding diathesis. Due to advances in treatment, life expectancy of haemophilia A sufferers is increasing, and the incidence and prevalence of coronary artery disease are rising. There have been many reported cases of acute myocardial infarction in such patients, who subsequently undergo elective percutaneous coronary intervention. We present the case of a 55-year-old gentleman presenting with an acute anterior full-thickness myocardial infarction who required emergency primary percutaneous coronary intervention.

Coronary angiography with or without percutaneous coronary intervention in patients with hemophilia—Systematic review

“…Dual antiplatelet therapy was started after PCI in most cases, but there are also reports with DAPT including loading doses of clopidogrel before PCI . We found one case of a patient treated with a loading dose of prasugrel , and two cases with loading doses of ticagrelor , but thereafter DAPT consisting of ASA and clopidogrel was used during follow‐up. Factor substitution during the period of DAPT was performed in 21 of 28 (75%) patients.…”

“…The process of search and article selection is shown in Figure . Information for the present analysis was extracted from 29 articles (case reports and small case series) .…”