Primary Peritoneal Clear Cell Adenocarcinoma Associated With Endometriosis

Müezzínoğlu, Bahar; Çorak, Selin; Yücesoy, İzzet

doi:10.1097/pai.0b013e31820528e7

Cited by 9 publications

(14 citation statements)

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“…Outcomes were poor in five cases. Of these, three patients died within 6 months, and disease recurrence had occurred in two cases at 4 months and 32 months, respectively, after the initial therapy [6,8–11]. Three patients died within 6 months and each had a residual tumor of >2 cm [5,7,9].…”

Section: Discussionmentioning

confidence: 99%

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Clear cell adenocarcinoma of the peritoneum: a case report and literature review

et al. 2014

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Clear cell adenocarcinoma (CCC) is generally thought to originate from ovarian, endometrial, or renal tissue. A CCC of the peritoneum (CCAP) is an extremely rare medical condition and is associated with a poor prognosis. To date, only 10 cases of CCAP have been reported, of which half resulted in death or recurrence within 6 months after initial treatment because CCAP is commonly resistant to multiple drugs. In this report, we present a case of CCAP of the pouch of Douglas coexisting with an endometriosis and we offer a review of the related literature.

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Section: Discussionmentioning

confidence: 99%

“…The characteristic features of the cases with particularly poor prognosis were large residual tumors after primary surgery and inoperability. On the other hand, there were three cases with relatively good prognosis [8,9,11]. The primary features of these cases were having had an optimal or complete debulking surgery followed by chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Clear cell adenocarcinoma of the peritoneum: a case report and literature review

et al. 2014

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“…Case reports provide limited data, as there are only nine reports in the English medical literature (12‐19) . Although debulking surgery, (12,15,17,18) as well as debulking surgery with chemotherapy, (14,16,17,19) were used in these reports, outcomes remained suboptimal with two of six patients dying within six months (17,19) and one recurrence at 32 months (14) . The other cases remained disease free at 6 months, 12 months, and 20 months following completion of treatment (16‐18) .…”

Section: Discussionmentioning

confidence: 99%

“…Although debulking surgery, (12,15,17,18) as well as debulking surgery with chemotherapy, (14,16,17,19) were used in these reports, outcomes remained suboptimal with two of six patients dying within six months (17,19) and one recurrence at 32 months (14) . The other cases remained disease free at 6 months, 12 months, and 20 months following completion of treatment (16‐18) . Both cases of death occurred within six months when the patients had residual tumors of

> 2 cm

, whereas the other cases had no evidence of residual tumor following treatment (3) .…”

Section: Discussionmentioning

confidence: 99%

“…Unfortunately, most studies on outcomes of PPC do not include PP‐CCC (6‐8,11) . To date, there are only nine reported cases of PP‐CCC in the English medical literature, none of which were treated with radiation (12‐19) . In those cases reporting outcomes, prognosis was much poorer than has been seen in retrospective studies of PPC, with 33% (two of six cases) mortality within six months, and 100% mortality within six months in those with residual disease following initial therapy (3) .…”

Section: Introductionmentioning

confidence: 99%

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Primary peritoneal clear cell carcinoma treated with IMRT and interstitial HDR brachytherapy: a case report

Johnson

Prisciandaro

Zhou

et al. 2014

J Applied Clin Med Phys

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Primary peritoneal clear cell carcinoma (PP‐CCC), which is a rare tumor with poor prognosis, is typically managed with surgery and/or chemotherapy. We present a unique treatment approach for a patient with a pelvic PP‐CCC, consisting of postchemotherapy intensity‐modulated radiation therapy (IMRT) followed by interstitial high‐dose–rate (HDR) brachytherapy. A 54‐year‐old female with an inoperable pelvic‐supravaginal 5.6 cm T3N0M0 PP‐CCC tumor underwent treatment with 6 cycles of carboplatin and taxol chemotherapy. Postchemotherapy PET/CT scan revealed a residual 3.3 cm tumor. The patient underwent CT and MR planning simulation, and was treated with 50 Gy to the primary tumor and 45 Gy to the pelvis including the pelvic lymph nodes, using IMRT to spare bowel. Subsequently, the patient was treated with an interstitial HDR brachytherapy implant, planned using both CT and MR scans. A total dose of 15 Gy in 5 Gy fractions over two days was delivered with Ir‐192 HDR brachytherapy. The total prescribed equivalent 2 Gy dose (EQD2) to the HDR planning target volume (PTV) from both the EBRT and HDR treatments ranged between 63 and 68.8thinmathspaceGy2 due to differential dosing of the primary and pelvic targets. The patient tolerated radiotherapy well, except for mild diarrhea not requiring medication. There was no patient‐reported acute toxicity one month following the radiotherapy course. At four months following adjuvant radiation therapy, the patient had near complete resolution of local tumor on PET/CT without any radiation‐associated toxicity. However, the patient was noted to have metastatic disease outside of the radiation field, specifically lesions in the liver and bone. This case report illustrates the feasibility of the treatment of a pelvic PP‐CCC with IMRT followed by interstitial HDR brachytherapy boost, which resulted in near complete local tumor response without significant morbidity.PACS number: 87.55.‐x

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Tumors, Tumor-Like Lesions, and Metaplastic Lesions of the Peritoneum

Zimmermann

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Primary Peritoneal Clear Cell Adenocarcinoma Associated With Endometriosis

Cited by 9 publications

References 0 publications

Clear cell adenocarcinoma of the peritoneum: a case report and literature review

Clear cell adenocarcinoma of the peritoneum: a case report and literature review

Primary peritoneal clear cell carcinoma treated with IMRT and interstitial HDR brachytherapy: a case report

Tumors, Tumor-Like Lesions, and Metaplastic Lesions of the Peritoneum

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