Primary peritoneal high-grade serous carcinoma in a man: A case report

Guellil, Abdelali; Jabi, Rachid; Mabrouk, Mohamed Yassine; Bouzayan, Laila; Merhoum, Abdelali; Del, Gallo Gérald; Godart, Claire; Bouziane, Mohammed

doi:10.1016/j.amsu.2022.103605

Cited by 1 publication

(8 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Regarding the tumor markers, CA-125 was detected to be positive in most cases, including our case, except in three cases where it was not tested [ 7 - 9 ]. Additionally, carcinoembryonic antigen (CEA) was mostly negative, except in one case where it was positive (Shah et al).…”

Section: Discussionmentioning

confidence: 79%

“…Incidental diagnosis through the umbilical hernia sac has been described previously in a handful of female cases only [ 11 ]. So far, only six cases of symptomatic advanced PPSC in men have been reported in the literature [ 4 , 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…All cases in the literature showed positive staining for CK7, and positive results were observed for PAX8, Ber-EP4, epithelial membrane antigen (EMA), and CD15 in all tested cases. Calretinin was found to be positive in only one out of five tested cases [ 9 ]. TTF1, CK5/6, D2-40, vimentin, thyroglobulin, and CDX2 were negative in all tested cases.…”

Section: Discussionmentioning

confidence: 99%

“…HMWK and LMWK were tested in only one case [ 5 ], and they were found to be positive. Mesothelin, prostate specific antigen (PSA), and desmine were each tested once in three different cases, and they were found to be negative [ 6 , 7 , 9 ]. HBME and IMP3 were tested only once in two different cases and were found to be positive [ 8 , 9 ] (Table 2 ).…”

Section: Discussionmentioning

confidence: 99%

“…PPSC occurs in women during the fifth and sixth decades of life, with an estimated incidence of 6.78 cases per million and a median overall survival of 21-23.5 months [ 3 ]. To date, only six cases of PPSC in men have been reported in the literature [ 4 - 9 ].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Incidentally Diagnosed Low-Grade Primary Peritoneal Serous Carcinoma Within the Umbilical Hernia Sac in a Male: A Report of an Extremely Rare Case and Review of the Literature

Ganam,

Khan,

Riddle

et al. 2024

Cureus

View full text Add to dashboard Cite

Primary peritoneal serous carcinoma (PPSC) is a rare tumor that develops in the peritoneum. PPSC originates from embryonic nests of Müllerian cells in the peritoneum, which are also present in the epithelium of the ovary. This similarity explains the histopathological resemblance between PPSC and low-grade serous ovarian carcinoma. While PPSC primarily affects women, it is an extremely rare occurrence in males, and it is believed that the significant difference in diagnosis rates between males and females is due to the inhibition of Müllerian system growth by substances produced by male Sertoli cells. These substances are present at higher levels in males, which may prevent the development of Müllerian system-derived tumors in men. We describe a 65-year-old male patient who presented for elective bariatric surgery and umbilical hernia repair, and an incidental finding of low-grade PPSC was made based on hernia sac pathology. The patient underwent further management, including tumor debulking and hyperthermic intraperitoneal chemotherapy (HIPEC), with positive outcomes. Long-term follow-up and oral letrozole treatment are planned.

show abstract

Section: Discussionmentioning

confidence: 79%