Primary peritoneal psammocarcinoma

Arole, Vidya; Deshpande, Kalpana A.; Jadhav, Dipashri Bhaurao; Jogi, Akash

doi:10.1111/jog.13355

“…15 Calcified leiomyomatosis peritonealis disseminata (LPD), an infrequent subtype of leiomyomatosis occurring amongst young women with history of myomectomy, is another differential diagnosis of PPP. 16 We could rule out this diagnosis since our patient was 74 years-old with no history of myomectomy.…”

Section: Discussionmentioning

confidence: 90%

Case Report: Incidental discovery of primary peritoneal psammocarcinoma

Helal,

Khanchel,

Jouini

et al. 2023

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Psammocarcinoma is an uncommon subtype of low-grade serous carcinoma. It is characterized by the presence of extensive psammoma bodies and can have either an ovarian or peritoneal origin. To our knowledge fewer than 30 cases of primary peritoneal psammocarcinoma (PPP) have been reported in the English literature. We report a rare case of PPP in a 74-year-old female, discovered fortuitously within a laparotomy for gallbladder lithiasis. At laparotomy, multiple nodular implants involving the omentum, the peritoneum and a magma of intestinal loops in the right iliac fossa were noted. A biopsy from nodules was performed. Gross examination showed multiple nodules of different sizes in the fat tissue. Pathologic examination showed massive psammoma bodies representing more than 75% of the tumor. The final diagnosis was psammocarcinoma. Our patient was referred to the gynecologic department for further investigation and to ascertain whether the tumor arose from the ovaries or peritoneum. Hysterectomy, bilateral adnexectomy and omentectomy were performed. Macroscopic examination showed that both ovaries were intact having a normal size. No invasion of ovarian stroma was shown in microscopic examination. The patient died of SARS-CoV-2 (COVID-19) six days after the surgery. PPP is a rare type of low-grade serous carcinoma. The behavior of this tumor is unclear, and the treatment is not standardized because of its rarity and lack of long-term follow-up. More cases need to be studied for better understanding and improvement of the management protocols.

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“…15 Calcified leiomyomatosis peritonealis disseminata (LPD), an infrequent subtype of leiomyomatosis occurring amongst young women with history of myomectomy, is another differential diagnosis of PPP. 16 We could rule out this diagnosis since our patient was 74 years-old with no history of myomectomy.…”

Section: Discussionmentioning

confidence: 90%

“…3 Chemotherapy is thought to have a poor efficiency in PPP. 16 However, follow-up adjuvant chemotherapy is required, at least for residual diseases and for PPP with aggressive behavior like in the case reported by Akbulut et al 7,21 Given their rarity, we do not dispose enough elements to judge the scalability of PPPs. However, PPP is likely to have a high potential towards peritoneal recurrence, even after suitable treatment.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Fortuitous discovery of primary peritoneal psammocarcinoma

Helal

¹

,

Khanchel

²

,

Jouini

³

et al. 2022

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Psammocarcinoma is an uncommon subtype of low-grade serous carcinoma. It is characterized by the presence of extensive psammoma bodies and can have either an ovarian or peritoneal origin. To our knowledge fewer than 30 cases of primary peritoneal psammocarcinoma (PPP) have been reported in the English literature. We report a rare case of PPP in a 74-year-old female, discovered fortuitously within a laparotomy for gallbladder lithiasis. At laparotomy, multiple nodular implants involving the omentum, the peritoneum and a magma of intestinal loops in the right iliac fossa were noted. A biopsy from nodules was performed. Gross examination showed multiple nodules of different sizes in the fat tissue. Pathologic examination showed massive psammoma bodies representing more than 75% of the tumor. The final diagnosis was psammocarcinoma. Our patient was referred to the gynecologic department for further investigation and to ascertain whether the tumor arose from the ovaries or peritoneum. Hysterectomy, bilateral adnexectomy and omentectomy were performed. Macroscopic examination showed that both ovaries were intact having a normal size. No invasion of ovarian stroma was shown in microscopic examination. The patient died of SARS-CoV-2 (COVID-19) six days after the surgery. PPP is a rare type of low-grade serous carcinoma. The behavior of this tumor is unclear, and the treatment is not standardized because of its rarity and lack of long-term follow-up. More cases need to be studied for better understanding and improvement of the management protocols.

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“…Ovarian primary psammocarcinoma has been classified as a subtype of serous carcinoma with a relatively good prognosis. 1,2 On the other hand, it has been reported that the presence and extent of sand grains do not correlate with prognosis. 4,5 On imaging examination, although CT scan exhibits a large amount of calcification in the ovarian tumor, it is very difficult to rule it out from other benign calcified diseases such as calcified leiomyoma, Brenner tumor, and fibrothecoma.…”

Section: Discussionmentioning

confidence: 99%

“…Many psammoma bodies are found in tumor tissue, and their prognosis is relatively good. 1,2 We report a case of primary ovarian serous psammocarcinoma in which preoperative computed tomography (CT) examination of the abdomen was useful for diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Primary ovarian serous psammocarcinoma-a case report with mini literature review

Baba¹,

Fukagawa²,

Itamochi³

et al. 2020

OGIJ

1

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Serous psammocarcinoma is a rare subtype of serous carcinoma in which a significant number of psammoma bodies are present histologically. Because it is an extremely rare disease, the pathogenesis of the disease remains unclear. Here we present a case of primary ovarian serous psammocarcinoma in which computed tomography (CT) imaging of the abdomen was useful for the diagnosis. A female patient was referred to our department with a complaint of abdominal distention. Pelvic magnetic resonance imaging revealed a multifocal tumor with a papillary enhancement in the right appendicular region, and abdominal CT imaging exhibited marked calcification of the enhancement. She underwent a laparotomy for suspected right ovarian cancer. As postoperative pathological examination revealed dominant stromal infiltration of psammoma bodies beneath peritoneum, this case was diagnosed as primary ovarian serous psammocarcinoma at FIGO Stage IIB. The patient was treated with six courses of paclitaxel plus carboplat in after the surgery. She is currently under outpatient observation without any signs of recurrence after 8 years of treatment. The case of significant calcification of the intra cystic enrichment on CT imaging is considered to be a case of this disease.

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Primary peritoneal psammocarcinoma

Cited by 5 publications

References 19 publications

Case Report: Incidental discovery of primary peritoneal psammocarcinoma

Case Report: Incidental discovery of primary peritoneal psammocarcinoma

Case Report: Fortuitous discovery of primary peritoneal psammocarcinoma

Primary ovarian serous psammocarcinoma-a case report with mini literature review

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