Primary peritoneal serous carcinoma, an extremely rare malignancy: A case report and review of the literature

Abstract

Abstract. Primary peritoneal serous carcinoma (PPSC) is an extremely rare malignancy that was first described in 1959. This type of cancer arises from the peritoneal epithelium and is similar to serous ovarian carcinoma. A diagnosis of PPSC is typically made based on the Gynecology Oncology Group criteria; however, a correct differential diagnosis of PPSC is difficult preoperatively. The current study describes the case of a 66 year-old female patient presenting with abdomen distension. A computed tomography (CT) scan revealed abundant ascites in the abdominal cavity and omental infiltration. The results of positron emission tomography/CT showed hot uptake in the greater omentum. Furthermore, preoperative serum cancer antigen-125 levels were 1,032 U/ml. Upon surgical exploration, a whitish mass and nodule were found in the greater omentum. Therefore, omentectomy was performed. Pathological examination of the resected specimen revealed a diagnosis of PPSC. PPSC is extremely rare with few cases cited in the current literature. The present study describes a rare case of PPSC with a review of the literature.

Narrative review on serous primary peritoneal carcinoma of unknown primary site: four questions to be answered

“…It can be argued that patients with complete response to neoadjuvant chemotherapy and no residual disease do not require surgical intervention. HIPEC is a therapeutic strategy that has developed over the past two decades and consists of delivering chemotherapy directly into the peritoneum, making it a good option for local control of peritoneal carcinomatosis (104,105). One case series of 32 patients with SPPC treated with CRS followed by HIPEC showed a 1, 3 and 5-year overall survival of 93.6%, 71.5%, and 57.4%, respectively (106).…”

Hyperthermic intraperitoneal chemotherapy in primary peritoneal cancer: Our experience in a young male

“…The median survival time is 23.5 months and 5-year survival rates range from 0% to 26.5%. [4] Once the diagnosis was established, maximal cytoreduction becomes the primary goal of the management. [3] HIPEC involves a procedure of peritoneal lavage by chemotherapeutic agents at a higher temperature.…”

Primary peritoneal carcinoma presenting as a case of ascites

“…A PPC is referred to by many names including an extra-ovarian primary peritoneal carcinoma (EOPPC), primary peritoneal serous carcinoma, Serous surface papillary carcinomamesothelioma, papillary carcinoma of the peritoneum, serous surface papillary carcinoma, and extraovarian papillary serous carcinoma; these names reflect a debate on the histogenesis and clinical behavior of the tumor. PPC is occurring in only around 6.78 cases per 1,000,000 individuals[ 1 ] Histologically, it is indistinguishable from primary epithelial ovarian carcinoma and is diagnosed in the absence of other identifiable primary sites. [ 2 ] People who are diagnosed with PPC tend to be older than those with ovarian cancer.…”