Primary pleomorphic liposarcoma of bone: MRI findings and review of the literature

Torigoe, Tomoaki; Matsumoto, Takeshi; Terakado, Atsuhiko; Takase, Masaru; Yamasaki, Shigetaka; Kurosawa, Hisashi

doi:10.1007/s00256-005-0018-8

Cited by 21 publications

(10 citation statements)

References 15 publications

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“…Liposarcomas of bone are rare and their MRI appearances include the presence of fat but aggressive features such as bone destruction are usually evident [33,34]. MRI depicts mature fat as intramedullary regions of high T1W SI, high T2W SI greater than subcutaneous fat, and low SI on STIR.…”

Section: Fat Si Within Tumoursmentioning

confidence: 97%

The role of MR imaging in the diagnostic characterisation of appendicular bone tumours and tumour-like conditions

et al. 2007

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MRI has an established role in the local staging of primary bone tumours. However, as the majority of tumours have non-specific appearances on MRI, the diagnosis is usually established on the basis of clinical history, plain film findings and biopsy. This article reviews the value of MRI in the further characterisation of appendicular bone tumours and tumour-like lesions, with particular reference to peri-lesional oedema, fluid-fluid levels, flow voids, fat signal, cartilage signal and dedifferentiation. These features are a useful adjunct for distinguishing between benign and malignant disease, pointing towards a more specific diagnosis, and guiding biopsy.

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Section: Fat Si Within Tumoursmentioning

confidence: 97%

The role of MR imaging in the diagnostic characterisation of appendicular bone tumours and tumour-like conditions

et al. 2007

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“…Chemotherapy is another treatment modality selected by certain clinicians rather than surgery. Although the first case in 1982 reported the use of chemotherapy as the treatment strategy (5), a total of five cases have been reported (5,6,8,10,12), where combined-treatment chemotherapy was adopted; the survival times for these patients were 10, 16, 70, 7 and 3 months, respectively. In 1999, Rabah et al (8) reported the case of a patient with a liposarcoma of the humerus.…”

Section: Discussionmentioning

confidence: 99%

Primary dedifferentiated liposarcoma of the femur presenting with malignant fibrous histiocytoma: A case report and review of the literature

Zhang

Wang

2014

Oncology Letters

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In the current report a case of a 26-year-old male with a primary dedifferentiated liposarcoma of the femur accompanied by malignant fibrous histiocytoma is presented. The patient complained of a dull intermittent pain, for three months, along the anterolateral aspect of the right knee and was referred to Southwest Hospital (Chongqing, China) in May 2013. All of the radiographic findings, including radiography, magnetic resonance image and emission computed tomography (CT) supported the diagnosis of a primary malignant bone tumor. CT-guided biopsy results demonstrated blood clots and a small quantity of heterogeneous cells. Thus, a limb-salvage procedure, involving a wide resection and total knee endoprosthesis replacement, was performed in May 2012. The final pathological diagnosis was of a primary dedifferentiated liposarcoma of the femur and the dedifferentiated tissue was identified as malignant fibrous histiocytoma. On review of the literature, it was identified that primary intraosseous liposarcoma are a rare and malignant tumor of the skeletal system, with only a small number of cases reported in the English literature since 1980. To the best of our knowledge, a case of dedifferentiated liposarcoma has not previously been reported.

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“…Less than 35 cases have been reported, 9 and only 20 of these fulfilled the criteria for primary liposarcoma of bone, 2 and only 16 had definitive photomicrographs. 3 High-grade soft-tissue liposarcomas do not respond well to treatment (including a combination of surgery and multimodal therapies). Five-year survival rates are <67%, with up to 50% of patients developing local recurrence or metastatic disease within 5 years, 7,17,[30][31][32][33][34] and tumours may recur even 10 years after treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Liposarcomas are uncommon tumours of primitive mesenchymal derivation occurring mostly in adults, [1][2][3][4] with an annual incidence of 2.5 per million in the US. They account for 10 to 15% of soft-tissue sarcomas.…”

Section: Discussionmentioning

confidence: 99%

Primary Intra-Osseous Liposarcoma of the Femur: A Case Report

Macmull¹,

Atkinson²,

Saso³

et al. 2009

J Orthop Surg (Hong Kong)

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We report a rare case of an intra-osseous liposarcoma of the proximal femur. A 26-year-old man presented with a 6-month history of left groin pain radiating to the knee and an antalgic gait. Radiology showed a predominantly fatty lesion in the medial aspect of the femoral neck extending toward the lesser trochanter; most of the marrow in the femoral neck had been replaced without evidence of an extra-osseous mass; and the posterior cortex had been destroyed. Histological and immunohistochemical analyses of the tumour after open biopsy were indicative of highgrade liposarcomatous malignancy. After exclusion of any other primary tumour foci or metastases on regional and whole-body magnetic resonance images, the diagnosis of a high-grade intra-osseous primary liposarcoma of the proximal femur was made. The patient received 2 preoperative courses of neoadjuvant doxorubicin, cisplatin and methotrexate. After proximal femoral replacement following en bloc excision of the proximal femur, 4 more cycles of adjuvant ifosfamide and etoposide were given. At the 16-month follow-up, he remained independently ambulatory, with no local or distant recurrence. Tissue diagnosis and multimodal imaging, rather than any single radiological investigation, are important in making the diagnosis.

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Primary pleomorphic liposarcoma of bone: MRI findings and review of the literature

Cited by 21 publications

References 15 publications

The role of MR imaging in the diagnostic characterisation of appendicular bone tumours and tumour-like conditions

The role of MR imaging in the diagnostic characterisation of appendicular bone tumours and tumour-like conditions

Primary dedifferentiated liposarcoma of the femur presenting with malignant fibrous histiocytoma: A case report and review of the literature

Primary Intra-Osseous Liposarcoma of the Femur: A Case Report

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