Primary Pneumonic Plague Contracted from a Mountain Lion Carcass

Wong, David; Wild, Margaret A.; Walburger, Matthew A.; Higgins, Charles L.; Callahan, Michael F.; Czarnecki, Lawrence A.; Lawaczeck, Elisabeth; Levy, Craig; Patterson, Jan; Sunenshine, Rebecca; Adem, Patricia; Paddock, Christopher D.; Zaki, Sherif R.; Petersen, Jeannine M.; Schriefer, Martin E.; Eisen, Rebecca J.; Gage, Kenneth L.; Griffith, Kevin S.; Weber, Ingrid; Spraker, Terry R.; Mead, Paul S.

doi:10.1086/600818

Cited by 69 publications

(58 citation statements)

References 20 publications

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“…Though other studies have investigated zoonotic disease risks among national parks (Boyer et al 1977;McLean et al 1989;New et al 1993;Gese et al 1997;Mills et al 1998;Paul et al 2002;Reeves 2007;Levine et al 2008;Wong et al 2009), none have addressed the breadth of pathogens evaluated here. These parks were selected due to their popularity among visitors and the likelihood of the presence of local zoonoses.…”

Section: Discussionmentioning

confidence: 99%

“…In November 2007, a wildlife biologist from Grand Canyon National Park died of pneumonic plague following transport and necropsy of an infected mountain lion carcass (Wong et al 2009). Outbreaks of tick-borne relapsing fever have occurred among visitors staying in rustic cabins in Grand Canyon National Park (Boyer et al 1977;Paul et al 2002), and adjacent to Rocky Mountain National Park (ROMO; Trevejo et al 1998).…”

Section: Introductionmentioning

confidence: 99%

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Zoonotic Infections Among Employees from Great Smoky Mountains and Rocky Mountain National Parks, 2008–2009

Adjemian

Weber

McQuiston

et al. 2012

Vector-Borne and Zoonotic Diseases

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Zoonotic Infections Among Employees from Great Smoky Mountains and Rocky Mountain National Parks, 2008–2009

Adjemian

Weber

McQuiston

et al. 2012

Vector-Borne and Zoonotic Diseases

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“…The biologist's autopsy of the mountain lion showed blood in the nares, chest cavity, and lung, as well as Y. pestis in tissue specimens. 11 The patient had thought the animal died of chest trauma inflicted by another lion, explaining why he took no precautions while handling the carcass and not wearing gloves or face mask during the autopsy carried out in his garage.…”

Section: Deaths Of Two United States Scientists In Accidental Exposuresmentioning

confidence: 99%

“…The purpose of this review is to examine the importance of plague during the first decade of this century with an emphasis on novel events and progress of clinical knowledge (Table 1). [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] Relevant literature was obtained by searching Pubmed for papers covering the years 2000-2009.…”

Section: Introductionmentioning

confidence: 99%

Plague Gives Surprises in the First Decade of the 21st Century in the United States and Worldwide

Butler¹

2013

The American Society of Tropical Medicine and Hygiene

112

105

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Abstract. Plague is an ancient disease caused by the bacterium Yersinia pestis and transmitted by rodent flea bites that continues to surprise us with first-ever events. This review documents plague in human cases in the 1st decade of the 21st century and updates our knowledge of clinical manifestations, transmission during outbreaks, diagnostic testing, antimicrobial treatment, and vaccine development. In the United States, 57 persons were reported to have the disease, of which seven died. Worldwide, 21,725 persons were affected with 1,612 deaths, for a case-fatality rate of 7.4%. The Congo reported more cases than any other country, including two large outbreaks of pneumonic plague, surpassing Madagascar, which had the most cases in the previous decade. Two United States scientists suffered fatal accidental exposures: a wildlife biologist, who carried out an autopsy on a mountain lion in Arizona in 2007, and a geneticist with subclinical hemochromatosis in Chicago, who was handling an avirulent strain of Y. pestis in 2009. Antimicrobial drugs given early after the onset of symptoms prevented many deaths; those recommended for treatment and prophylaxis included gentamicin, doxycycline, and fluoroquinolones, although fluoroquinolones have not been adequately tested in humans. Fleas that do not have their guts blocked by clotted blood meals were shown to be better transmitters of plague than blocked fleas. Under development for protection against bioterrorist use, a subunit vaccine containing F1 and V antigens of Y. pestis was administered to human volunteers eliciting antibodies without any serious side effects. These events, although showing progress, suggest that plague will persist in rodent reservoirs mostly in African countries burdened by poverty and civil unrest, causing death when patients fail to receive prompt antimicrobial treatment.

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“…Human disease following animal necropsy has been reported for Ebola in chimpanzees (Pan troglodytes) (Le Guenno et al 1995) and plague in mountain lions (Puma concolor) (Wong et al 2009). A 1996 outbreak of Ebola was linked to the transport, butchering, and consumption of a chimpanzee carcass found dead in the forest (Pourrut et al 2005).…”

mentioning

confidence: 99%

Collection and Utilization of Animal Carcasses Associated with zoonotic Disease in Tshuapa District, the Democratic Republic of the Congo, 2012

Monroe

Doty

Moses³

et al. 2015

Journal of Wildlife Diseases

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ABSTRACT:The collection and consumption of animal carcasses is a common activity in forested areas of the Congo River basin and creates sustainability, conservation, and health concerns. Residents of the Tshuapa District reported collecting the remains of 5,878 animals from .30 species when surveyed about their wildlife consumption habits. Carcasses were discovered in varying degrees of decomposition and were often consumed at home or sold in local markets. The most commonly collected animals were Cricetomys gambianus (Northern giant pouched rat), Cercopithecus ascanius (red-tailed monkey), and Heliosciurus rufobrachium (red-legged sun squirrel). Many of the species recorded may be hosts of zoonotic pathogens, creating concern for spillover events.

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Primary Pneumonic Plague Contracted from a Mountain Lion Carcass

Cited by 69 publications

References 20 publications

Zoonotic Infections Among Employees from Great Smoky Mountains and Rocky Mountain National Parks, 2008–2009

Zoonotic Infections Among Employees from Great Smoky Mountains and Rocky Mountain National Parks, 2008–2009

Plague Gives Surprises in the First Decade of the 21st Century in the United States and Worldwide

Collection and Utilization of Animal Carcasses Associated with zoonotic Disease in Tshuapa District, the Democratic Republic of the Congo, 2012

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