Primary Prevention of Atherosclerosis

Napoli, Claudio; Crudele, Valeria; Soricelli, Andrea; Al‐Omran, Mohammed; Vitale, Nicoletta; Infante, Teresa; Mancini, Francesco Paolo

doi:10.1161/circulationaha.111.085787

Cited by 108 publications

(63 citation statements)

References 132 publications

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“…More recent investigations have demonstrated that DNA methylation has a varied influence on gene expression [98]. Despite uncertainty with regard to its effect on gene expression, there is accumulating evidence implicating DNA methylation in several common chronic human disease states including atherosclerosis [99]. Furthermore, cigarette smoking has proven to be a powerful environmental modifier of DNA methylation and is a potential mechanism by which tobacco can affect gene expression [100].…”

Section: Role For Epigenetics In Aaa Pathogenesismentioning

confidence: 99%

Understanding the pathogenesis of abdominal aortic aneurysms

Kuivaniemi

Ryer

Elmore

et al. 2015

Expert Review of Cardiovascular Therapy

309

240

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Summary An aortic aneurysm is a dilatation in which the aortic diameter is ≥ 3.0 cm. If left untreated, the aortic wall continues to weaken and becomes unable to withstand the forces of the luminal blood pressure resulting in progressive dilatation and rupture, a catastrophic event associated with a mortality of 50 – 80%. Smoking and positive family history are important risk factors for the development of abdominal aortic aneurysms (AAA). Several genetic risk factors have also been identified. On the histological level, visible hallmarks of AAA pathogenesis include inflammation, smooth muscle cell apoptosis, extracellular matrix degradation, and oxidative stress. We expect that large genetic, genomic, epigenetic, proteomic and metabolomic studies will be undertaken by international consortia to identify additional risk factors and biomarkers, and to enhance our understanding of the pathobiology of AAA. Collaboration between different research groups will be important in overcoming the challenges to develop pharmacological treatments for AAA.

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Section: Role For Epigenetics In Aaa Pathogenesismentioning

confidence: 99%

Understanding the pathogenesis of abdominal aortic aneurysms

Kuivaniemi

Ryer

Elmore

et al. 2015

Expert Review of Cardiovascular Therapy

309

240

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“…While the first mechanism underlies epigenetic inheritance, the second defines and allows transgenerational epigenetics. 59,60 Metabolic disorders, including diabetes, can be dependent on altered epigenetic reprogramming in utero. 61 On the contrary, transgenerational effects are responsible for epigenetic changes also in later progenies that have not been exposed to the starting environmental stimulus.…”

Section: Transgenerational Epigenetic Inheritance Of T2dmmentioning

confidence: 99%

Clinical relevance of epigenetics in the onset and management of type 2 diabetes mellitus

et al. 2017

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Epigenetics is involved in the altered expression of gene networks that underlie insulin resistance and insufficiency. Major genes controlling b-cell differentiation and function, such as PAX4, PDX1, and GLP1 receptor, are epigenetically controlled. Epigenetics can cause insulin resistance through immunomediated pro-inflammatory actions related to several factors, such as NF-kB, osteopontin, and Toll-like receptors. Hereafter, we provide a critical and comprehensive summary on this topic with a particular emphasis on translational and clinical aspects. We discuss the effect of epigenetics on b-cell regeneration for cell replacement therapy, the emerging bioinformatics approaches for analyzing the epigenetic contribution to type 2 diabetes mellitus (T2DM), the epigenetic core of the transgenerational inheritance hypothesis in T2DM, and the epigenetic clinical trials on T2DM. Therefore, prevention or reversion of the epigenetic changes occurring during T2DM development may reduce the individual and societal burden of the disease.

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“…PJK terutama disebabkan oleh aterosklerosis (Napoli et al, 2012) di mana salah satu faktor penyebabnya adalah hiperkolesterolemia (Nelson, 2013dan Murray et al 2003 akibat peningkatan Low density lipoprotein cholesterol (LDL-C) di dalam darah (Napoli et al, 2012). Hiperkolesterolemia dapat dihubungkan dengan salah satu efek utama akibat kurangnya insulin pada penderita diabetes melitus (Guyton dan Hall, 1997:1235.…”

Section: Pendahuluanunclassified

POTENSI BUAH MERAH (Pandanus conoideus Lam.) DALAM MENURUNKAN KADAR LDL DARAH TIKUS PUTIH

Agnesa¹,

Waluyo

Prihatin

et al. 2017

Bioeksperimen

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Abstrak-Penyakit jantung koroner (PJK) terutama disebabkan oleh aterosklerosis karena hiperkolesterolimia. Oksidasi low density lipoprotein (LDL) oleh reactive oxygen species (ROS) sebagai penyebab utama proses aterogenik dapat dicegah dengan kehadiran antioksidan seperti vitamin E. Buah dan sayuran banyak mengandung vitamin. Salah satu buah yang mengandung vitamin E adalah buah merah (Pandanus conoideus Lam.). Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak buah merah terhadap kadar LDL darah pada tikus putih (Rattus norvegicus L.). Jenis penelitian ini adalah penelitian eksperimental laboratorium yang didesain mengikuti Rancangan Acak Lengkap (RAL) dengan 6 perlakuan dan 4 kali ulangan dengan parameter penelitian adalah kadar LDL darah tikus putih. Data dianalisis menggunakan one way anova dilanjutkan dengan uji Duncan 95%. Berdasarkan hasil penelitian, minyak buah merah memiliki kemampuan untuk menurunkan kadar LDL darah tikus putih.Kata Kunci: minyak buah merah, aterosklerosis, LDL.

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Primary Prevention of Atherosclerosis

Cited by 108 publications

References 132 publications

Understanding the pathogenesis of abdominal aortic aneurysms

Understanding the pathogenesis of abdominal aortic aneurysms

Clinical relevance of epigenetics in the onset and management of type 2 diabetes mellitus

POTENSI BUAH MERAH (Pandanus conoideus Lam.) DALAM MENURUNKAN KADAR LDL DARAH TIKUS PUTIH

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