Primary prevention of CRC

Rocha, José Luis; Ferreiro, Raquel Sardina; Suarez, Rosa Fungueiriño; Vázquez, Juan Turnes

doi:10.1016/b978-0-323-90055-3.00002-8

Cited by 2 publications

(1 citation statement)

References 65 publications

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“…Hereditary and environmental factors contribute to the development of CRC and, thus, affect CRC risk. In particular, the greatest increase in risk is based on inherited susceptibility [ 44 ]. If this cancer were found to have an infectious etiology, the potential for diagnostic tools and therapeutic interventions would be substantial.…”

Section: Discussionmentioning

confidence: 99%

Human Papillomavirus and Risk of Colorectal Cancer: An Analysis of Nationwide Claims Data

et al. 2022

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Background and Objectives: Although human papillomavirus (HPV) is a major etiology of cervical and anogenital cancers, whether it is associated with colorectal carcinogenesis is yet undetermined. Materials and Methods: The longitudinal association of HPV infection with colorectal cancer (CRC) was evaluated using 2000–2013 data from a nationwide Taiwanese claims database. In this retrospective cohort study, 358 patients with primary HPV diagnoses (HPV-infected cohort) and 1432 patients without such a diagnosis (HPV-uninfected cohort) were recruited between 2000 and 2006. Both cohorts were followed up to identify CRC incidences from 2006 to 2013. Hazard ratios (HRs) and their 95% confidence intervals (CIs) derived from Cox proportional hazards models were used to estimate the association between HPV and CRC risk. Results: The HPV-infected cohort had a significantly higher cumulative incidence of CRC than the HPV-uninfected cohort. The presence of HPV was associated with an increased risk of CRC (adjusted HR, 1.63; 95% CI, 1.02–3.62). Furthermore, the significant HPV–CRC risk association was evident in both sexes. Conclusions: This population-based cohort study reveals longitudinal evidence that HPV is associated with an increased risk of CRC. Further studies are required to verify the role of HPV in colorectal carcinogenesis.

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Section: Discussionmentioning

confidence: 99%

Human Papillomavirus and Risk of Colorectal Cancer: An Analysis of Nationwide Claims Data

et al. 2022

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A Comprehensive View on the Impact of Chlorogenic Acids on Colorectal Cancer

Neamțu,

Maghiar,

Turcuș

et al. 2024

CIMB

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Chlorogenic acids are plant secondary metabolites, chemically—polyphenols with similar biological activity, formed through the esterification of quinic acid and hydrocinnamic acid moieties. They are best known for their high concentration in coffee and other dietary sources and the antioxidant properties that they exhibit. Both chlorogenic acids and plant extracts containing significant amounts of the compounds show promising in vitro activity against colorectal cancer. With coffee being the most popular drink in the world, and colorectal cancer at an unfortunate peak in incidence and mortality, the mechanisms through which the anti-tumorigenic effect of chlorogenic acids could be functionalized for CRC prevention seem appealing to study. Therefore, this review aims to enable a better understanding of the modes of action of chlorogenic acids in combating carcinogenesis, with a focus on cell cycle arrest, the induction of apoptosis, and the modulation of Wnt, Pi3K/Akt, and MAPK signal transduction pathways, alongside the reduction in the number of inflammatory cytokines and chemokines and the counterintuitive beneficial elevation of oxidative stress.

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Primary prevention of CRC

Cited by 2 publications

References 65 publications

Human Papillomavirus and Risk of Colorectal Cancer: An Analysis of Nationwide Claims Data

Human Papillomavirus and Risk of Colorectal Cancer: An Analysis of Nationwide Claims Data

A Comprehensive View on the Impact of Chlorogenic Acids on Colorectal Cancer

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