Primary prevention of diseases of old age

Mehr, David R.; Tatum, Paul

doi:10.1016/s0749-0690(02)00019-8

Cited by 16 publications

(9 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The VES-13 has been used to assess vulnerability in older patients in various clinical and research settings, [5][6][7][8] but determining whether cancer screening or preventive services are likely to be beneficial [9][10][11][12][13] often involves predicting a patient's health and function over the next 5 or more years rather than the relatively short 1-to 2-year time frame over which the VES-13 has been studied. Practice guidelines targeted to appropriate treatment of older patients, such as the Clinical Glidepaths, 13 American Geriatrics Society's diabetes mellitus care guidelines for older patients, 14 and Assessing the Care of Vulnerable Elders (ACOVE) quality indicators advocate consideration of prognosis before applying evidence-based guidelines derived from studies of younger patients 15 (e.g., strict blood sugar control 16 ).…”

mentioning

confidence: 99%

The Vulnerable Elders‐13 Survey Predicts 5‐Year Functional Decline and Mortality Outcomes in Older Ambulatory Care Patients

Min

Yoon

Mariano

et al. 2009

J American Geriatrics Society

142

105

View full text Add to dashboard Cite

BACKGROUND The Vulnerable Elders-13 Survey (VES-13) is a short tool that predicts functional decline and mortality over a 1–2 year follow-up interval. Prognosis over longer intervals is often needed in clinical care. OBJECTIVE To test the predictive properties of the VES-13 over a 5-year interval. DESIGN Longitudinal evaluation with mean follow-up of 4.5 years. SETTING Two managed-care organizations. PARTICIPANTS 649 community-dwelling elders (age ≥75 and older) enrolled in the Assessing Care of Vulnerable Elders (ACOVE) observational study who screened positively for symptoms of fear of falling/falls, bothersome urinary incontinence, or memory problems. MEASUREMENTS VES-13 score (range 1–10, higher indicates worse prognosis); functional decline (defined as decline in count of 5 activities of daily living or nursing home entry); deaths. RESULTS Greater VES-13 scores are associated with greater predicted probability of death and decline among older patients over a mean observation period of 4.5 years. For each additional VES-13 point, the odds of the combined outcome of functional decline or death was 1.37 (95% CI 1.25–1.50), and the area under the receiver operating curve (AUC) was 0.75 (95% CI .71–.80). In the Cox proportional hazards model predicting time to death, the hazard ratio was 1.23 (95% CI 1.19–1.27) per additional VES-13 point. CONCLUSION This study extends the utility of the VES-13 to clinical decisions that require longer-term prognostic estimates of functional status and survival.

show abstract

mentioning

confidence: 99%

The Vulnerable Elders‐13 Survey Predicts 5‐Year Functional Decline and Mortality Outcomes in Older Ambulatory Care Patients

Min

Yoon

Mariano

et al. 2009

J American Geriatrics Society

142

105

View full text Add to dashboard Cite

show abstract

“…Todo ello, además, influido por el entorno psicosocial. Así pues, la instaura ción de la dependencia no es consecuencia inexorable de la edad al asociarse a otras variables sobre las que sí se puede intervenir tanto para evitar la aparición del esta do de dependencia como para moderar su evolución hacia una mayor gravedad [7][8][9][10][11] .…”

Section: Justificaciónunclassified

Prevención de la dependencia en las personas mayores

Pavón

Lesende

Cortés

et al. 2008

Revista Clínica Española

View full text Add to dashboard Cite

“…Due to the increased incidence with advancing age of chronic conditions, such as coronary heart disease, cancers, diabetes, and dementia, there is a need to develop primary preventive interventions to prolong the period of healthy life (Kirkland 2002; Mehr and Tatum 2002; Report of a Joint WHO/FAO Expert Consultation 2003; Eyre et al 2004; Topp et al 2004; Tse and Benzie 2004; Yamori 2004). Diet has a substantial influence on health and aging.…”

Section: Food Intake Longevity and Development Of Age-related Diseasesmentioning

confidence: 99%

Dietary approaches that delay age-related diseases

Everitt¹,

Hilmer²,

Brand-Miller³

et al. 2006

Clinical Interventions in Aging

144

View full text Add to dashboard Cite

Reducing food intake in lower animals such as the rat decreases body weight, retards many aging processes, delays the onset of most diseases of old age, and prolongs life. A number of clinical trials of food restriction in healthy adult human subjects running over 2–15 years show significant reductions in body weight, blood cholesterol, blood glucose, and blood pressure, which are risk factors for the development of cardiovascular disease and diabetes. Lifestyle interventions that lower energy balance by reducing body weight such as physical exercise can also delay the development of diabetes and cardiovascular disease. In general, clinical trials are suggesting that diets high in calories or fat along with overweight are associated with increased risk for cardiovascular disease, type 2 diabetes, some cancers, and dementia. There is a growing literature indicating that specific dietary constituents are able to influence the development of age-related diseases, including certain fats (trans fatty acids, saturated, and polyunsaturated fats) and cholesterol for cardiovascular disease, glycemic index and fiber for diabetes, fruits and vegetables for cardiovascular disease, and calcium and vitamin D for osteoporosis and bone fracture. In addition, there are dietary compounds from different functional foods, herbs, and neutraceuticals such as ginseng, nuts, grains, and polyphenols that may affect the development of age-related diseases. Long-term prospective clinical trials will be needed to confirm these diet—disease relationships. On the basis of current research, the best diet to delay age-related disease onset is one low in calories and saturated fat and high in wholegrain cereals, legumes, fruits and vegetables, and which maintains a lean body weight. Such a diet should become a key component of healthy aging, delaying age-related diseases and perhaps intervening in the aging process itself. Furthermore, there are studies suggesting that nutrition in childhood and even in the fetus may influence the later development of aging diseases and lifespan.

show abstract

Primary prevention of diseases of old age

Cited by 16 publications

References 59 publications

The Vulnerable Elders‐13 Survey Predicts 5‐Year Functional Decline and Mortality Outcomes in Older Ambulatory Care Patients

The Vulnerable Elders‐13 Survey Predicts 5‐Year Functional Decline and Mortality Outcomes in Older Ambulatory Care Patients

Prevención de la dependencia en las personas mayores

Dietary approaches that delay age-related diseases

Contact Info

Product

Resources

About