Primary Prevention of Food Allergy—Environmental Protection beyond Diet

Sikorska-Szaflik, Hanna; Sozańska, Barbara

doi:10.3390/nu13062025

Cited by 13 publications

(10 citation statements)

References 80 publications

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“…Further investigation is needed to determine optimal strategies across a multitude of topical agents that vary significantly in composition. Pre‐ and postnatal vitamin D supplements have also been proposed for the prevention of FA; however, at this time, the data from these studies are mixed and a clear conclusion has yet to be reached 67‐75 …”

Section: Diagnosis and Endotypingmentioning

confidence: 99%

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Food allergy, mechanisms, diagnosis and treatment: Innovation through a multi‐targeted approach

Sindher

Long

Chin

et al. 2022

Allergy

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The incidence of food allergy (FA) has continued to rise over the last several decades, posing significant burdens on health and quality of life. Significant strides into the advancement of FA diagnosis, prevention, and treatment have been made in recent years. In an effort to lower reliance on resource‐intensive food challenges, the field has continued work toward the development of highly sensitive and specific assays capable of high‐throughput analysis to assist in the diagnosis FA. In looking toward early infancy as a critical period in the development of allergy or acquisition of tolerance, evidence has increasingly suggested that early intervention via the early introduction of food allergens and maintenance of skin barrier function may decrease the risk of FA. As such, large‐scale investigations are underway evaluating infant feeding and the impact of emollient and steroid use in infants with dry skin for the prevention of allergy. On the other end of the spectrum, the past few years have been witness to an explosive increase in clinical trials of novel and innovative therapeutic strategies aimed at the treatment of FA in those whom the disease has already manifested. A milestone in the field, 2020 marked the approval of the first drug, oral peanut allergen, for the indication of peanut allergy. With a foundation of promising data supporting the safety and efficacy of single‐ and multi‐allergen oral immunotherapy, current efforts have turned toward the use of probiotics, biologic agents, and modified allergens to optimize and improve upon existing paradigms. Through these advancements, the field hopes to gain footing in the ongoing battle against FA.

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Section: Diagnosis and Endotypingmentioning

confidence: 99%

“…Pre-and postnatal vitamin D supplements have also been proposed for the prevention of FA; however, at this time, the data from these studies are mixed and a clear conclusion has yet to be reached. [67][68][69][70][71][72][73][74][75]…”

Section: Preventionmentioning

confidence: 99%

Food allergy, mechanisms, diagnosis and treatment: Innovation through a multi‐targeted approach

Sindher

Long

Chin

et al. 2022

Allergy

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“…The idea of the early introduction of allergenic food to achieve oral tolerance corresponding to the dualallergen exposure concept enabled the unresponsiveness to some food allergens in predisposed babies when they became older. 64 Allergen tolerance displayed different mechanisms and distinct molecule and cell sets at the regional (e.g., nasal) and systemic levels.…”

Section: The Physiological Maintenance Of Tolerance To Allergens In T...mentioning

confidence: 99%

Autonomous Breakdown of the Allergen Tolerance in the Nose: A Hypothesis

Klimov¹,

Klimov²,

Кошкарова³

2022

Explor Res Hypothesis Med

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The prevalence of conventional and new pathogenic types of allergies is increasing. For the last few years, new atopic disorders -local allergic rhinitis (LAR), local allergic asthma, "dual" allergic rhinitis, and local allergic conjunctivitis -have been described. In particular, LAR was identified a decade ago, whereas its immunopathogenesis is still unclear. Nevertheless, the network of immune cells and neurons determining the maintenance or breakdown of allergen tolerance has partially been studied. Therefore, this field of research is currently at the cutting edge. However, there is still not any definitive answer as to why local disorders take place. Specifically, the nasal cavity is characterized by the following prevalent neuro molecules: acetylcholine, norepinephrine, substance P, neuromedin U, vasoactive intestinal peptide, and calcitonin-gene-related peptide; some of which are pro-immunogenic and a slightly smaller part is protolerogenic. In the spotlight, the hypothesis of an autonomous breakdown of tolerance to allergens in LAR is presented. The article describes immune tolerance as the antipode of the active immune response, which does not lead to producing effector cells and molecules, and vice versa is based on active immunosuppressive processes. In addition, this article focuses on the mechanisms of the maintenance and breakdown of allergen tolerance, a form of immune tolerance, at the nasal level and throughout the body, and the essential role of various cells and molecules, including neuro molecules, in the pathogenesis of LAR.

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“…З огляду на значну асоціацію між раннім початком, а також середньотяжким і тяжким перебігом атопічного дерматиту та сенсибілізацією до їжі цілком ймовірно, що сенсибілізація до їжі відбувається переважно через запалений шкірний бар'єр в екзематозній шкірі, що потенційно може призвести до розвитку клінічної харчової алергії. запобігання розвитку ХА [2][3][4]. Крім того, для запобігання випадковому потраплянню харчових алергенів з'явилось кілька останніх досягнень промисловості щодо виявлення та видалення алергенів із оброблених продуктів [5].…”

Section: значення харчової алергії при атопічному дерматиті в дітейunclassified

Significance of food allergy in atopic dermatitis in children

Волосовец¹,

Kryvopustov

Mozyrska

et al. 2022

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Background. Atopic dermatitis is the most common inflammatory skin disease in childhood, affecting almost 20 % of children. Food allergies affect one of three children with atopic dermatitis, and allergies to peanuts, eggs and milk are the predominant food allergies in the world. The purpose was to assess the prevalence of food allergies in the group of patients with atopic dermatitis, to determine the association of food allergies with anamnestic and clinical parameters of atopic dermatitis. Materials and methods. Children with atopic dermatitis (n = 116) were included in the study from September 2020 to August 2021 in Kyiv, Ukraine. Food sensitization was established by determining specific immunoglobulin E (sIgE) to food allergens using immunochemiluminescent method on the ImmunoCAP 100 system (Thermo Fisher Scientific Inc., Phadia, Sweden). Results. The average age of children in the main group (59 boys and 57 girls) was 6.8 years. All 116 patients at the time of examination had manifestations of atopic dermatitis in the form of erythematous itchy rash. The number of children with food allergy was 23 (19.8 %). Among food allergens, positive sIgE were found: in 14 patients (12 %) — to milk, in 13 (11.2 %) — to eggs, in 5 (4.3 %) — to fish, and in 4 people (3.4 %) — to hazelnuts. Food sensitization was significantly more common in children with moderate-to-severe atopic dermatitis than in the group of patients with mild atopic dermatitis (χ2 = 7.555, p < 0.05). Children with food sensitization had an earlier onset of atopic dermatitis — the average age of manifestations onset was 8 months, and in the group of children without food allergy, it was 18 months. Children with a parental history of atopic diseases were significantly more likely to have concomitant food allergy (χ2 = 12.831, p < 0.05). Conclusions. Given the significant association between early onset as well as moderate-to-severe atopic dermatitis and food sensitization, it is likely that food sensitization occurs primarily through an inflamed skin barrier in eczematous skin, which could potentially lead to clinical food allergy.

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Primary Prevention of Food Allergy—Environmental Protection beyond Diet

Cited by 13 publications

References 80 publications

Food allergy, mechanisms, diagnosis and treatment: Innovation through a multi‐targeted approach

Food allergy, mechanisms, diagnosis and treatment: Innovation through a multi‐targeted approach

Autonomous Breakdown of the Allergen Tolerance in the Nose: A Hypothesis

Significance of food allergy in atopic dermatitis in children

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