Primary prophylaxis for febrile neutropenia: Is it really required for AC chemo regimen in breast cancer patients?

Abstract

enrolled in the exercise program, however 5 patients withdrew consent before commencement. Reasons for withdrawal were health concern (n ¼ 2), distance to the hospital (n ¼ 1) and unspecified (n ¼ 2). The completion rate of the 12-week exercise program was 78.6% (11/14). Disease progression (n ¼ 2) was the main reason for early discontinuation. The adherence rate of the supervised exercise session was 78.1% (207/ 265) and there was no adverse event associated with the exercise training. Among participants in the exercise program, there was no significant change in skeletal muscle index from baseline to post-intervention (mean, 9.461.3kg/m 2 vs 9.461.2kg/m 2 , p ¼ 0.982). FACIT-fatigue scale was non-significantly improved after the exercise intervention (mean, 35.2610.4 vs 38.269.8, p ¼ 0.635). Conclusions: Exercise interventions appear to be feasible and safe in patients with advanced solid cancer and might have a role of preventing skeletal muscle loss without fatigue exacerbation during palliative chemotherapy. Legal entity responsible for the study: Young Saing Kim.