Primary prostatic haemangiosarcoma causing severe haematuria in a dog

Santa, Daniele Della; Dandrieux, Julien; Psalla, Dimitra; Gorgas, Daniela; Lang, Johann; Geissbuehler, U.; Howard, John Philpott -

doi:10.1111/j.1748-5827.2007.00501.x

Cited by 10 publications

(10 citation statements)

References 12 publications

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“…On both ultrasonography and CT, the origin of the mass was not clear, but its exophytic distribution resembled that described in a former case report of prostatic leiomyoma, 10 supporting the diagnosis of a benign mass. However, the previously reported prostatic leiomyoma appeared as a homogenous soft tissue attenuating mass with homogenous contrast enhancement on CT, whereas in our case some large cyst‐like hypoattenuating areas with no contrast enhancement were present, as previously reported in prostatic leiomyosarcoma, 4,5 prostatic hemangiosarcoma, 18 and malignant intrapelvic masses 19,20 …”

Section: Case Descriptionsupporting

confidence: 78%

Prostatic leiomyosarcoma in a dog treated using a multimodal approach

Trovatelli

Bassi

Giudice

et al. 2021

Veterinary Internal Medicne

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Prostatic leiomyosarcoma is an uncommon tumor encountered in male dogs, with only 2 cases reported in the veterinary literature with no follow-up described. A 12-year-old male intact German Wirehaired Pointer presented for evaluation of straining to defecate and urinate. Whole body computed tomography (CT) examination identified a spherical multicavitary expansile mass arising from the prostate gland and severely obliterating the pelvic canal. Partial subcapsular prostatectomy was performed, and histological and immunohistochemical results were consistent with prostatic leiomyosarcoma. Metronomic cyclophosphamide and nonsteroidal antiinflammatory drugs were administered as adjuvant chemotherapy. Follow-up CT 10 months later indicated no signs of recurrence or metastasis. To the best of our knowledge, this patient represents the first report of successful multidisciplinary treatment consisting of partial subcapsular prostatectomy and adjuvant chemotherapy for prostatic leiomyosarcoma in a dog. After 15 months of follow-up, the patient remained recurrence-free without metastasis.

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Section: Case Descriptionsupporting

confidence: 78%

Prostatic leiomyosarcoma in a dog treated using a multimodal approach

Trovatelli

Bassi

Giudice

et al. 2021

Veterinary Internal Medicne

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“…Tumors of nonepithelial origin are particularly rare within the prostatic gland . Fibrosarcoma, leiomyosarcoma, leiomyoma, and hemangiosarcoma have been identified in the canine prostate . Only individual cases of malignant lymphoma affecting the prostate in dogs have been reported so far .…”

Section: Introductionmentioning

confidence: 99%

Predominance of hypoechoic tissue changes in nine dogs with malignant prostatic lymphoma

Donato

Zweifel

Koehler

et al. 2018

Vet Radiology Ultrasound

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Neoplasia of the prostate is relatively uncommon in dogs with adenocarcinoma being the most common type. Non‐epithelial tumors are rare and only individual cases of malignant lymphoma affecting the prostate have been reported. The purpose of this multi‐institutional, retrospective, descriptive study was to characterize the ultrasonographic features of canine prostatic lymphoma. Inclusion criteria were an abdominal ultrasound and cytological/histological diagnosis of malignant prostatic lymphoma. Ultrasonographic features were recorded based on the original ultrasonographic reports and consensus opinion of two readers on the available image sets retrospectively. Nine dogs met the inclusion criteria with a mean age of 6.5 years. Seven dogs were intact and two neutered. Subjective prostatomegaly was noted in all patients however not reproducible by objective measurements. Altered shape with rounded/irregular margins was detected in 78% of the cases. All prostates presented either diffuse (three dogs) or focal/periurethral (four dogs) and/or multifocal areas of hypoechogenicity (three dogs). In one dog, focal and multifocal hypoechoic changes co‐occurred. Prostatic mineralization was not present in any of the cases. Ultrasonographic features of infiltrative disease of multiple organs and/or lymphadenopathy was found in all cases. Even though malignant lymphoma is rare in the prostate, it should be included in the list of differentials in patients with hypoechoic lesions/areas, altered shape, lack of mineralization of the prostatic parenchyma and evidence of multiorgan involvement.

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“…This tumour most commonly arises in middle‐aged to older dogs and has increased prevalence in German Shepherd dogs, Golden and Labrador Retrievers, Pointers, Boxers, English Setters, Great Danes, Poodles and Siberian Huskies 1–11 . These tumours most commonly arise from the spleen, but can also be found primarily in the right atrium, liver, subcutis, muscle and several other locations 1–3,7–29 . Metastasis occurs most commonly in the lungs and liver, but has also been reported in the omentum, mesentery, kidney, intestines, bone, adrenal glands, peritoneum, diaphragm, lymph nodes and brain 1–3,6,8,11–13,23,26,30,31 .…”

Section: Introductionmentioning

confidence: 99%

Efficacy of doxorubicin-based chemotherapy for non-resectable canine subcutaneous haemangiosarcoma

Wiley

Rook

Clifford³

et al. 2010

Veterinary and Comparative Oncology

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Eighteen dogs with measurable subcutaneous haemangiosarcoma (SQHSA) were treated with doxorubicin-based chemotherapy. Response assessment was evaluated and compared using World Health Organization (WHO), Response Evaluation Criteria in Solid Tumours (RECIST) and tumour volume criteria. The overall response rate for all dogs was 38.8% using WHO criteria, 38.8% using RECIST criteria and 44% using tumour volume criteria. One dog had a complete response. The median response duration for all dogs was 53 days (range 13-190 days). Four dogs had complete surgical excision after neoadjuvant chemotherapy. The median progression-free interval for dogs with complete surgical excision after neoadjuvant chemotherapy was significantly longer than those not having surgical excision (207 days versus 83 days, respectively) (P = 0.003). No significant difference in metastasis-free interval or survival time was found between the groups. Doxorubicin-based chemotherapy appears to be effective for non-resectable canine SQHSA, although the response duration is relatively short.

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Primary prostatic haemangiosarcoma causing severe haematuria in a dog

Cited by 10 publications

References 12 publications

Prostatic leiomyosarcoma in a dog treated using a multimodal approach

Prostatic leiomyosarcoma in a dog treated using a multimodal approach

Predominance of hypoechoic tissue changes in nine dogs with malignant prostatic lymphoma

Efficacy of doxorubicin-based chemotherapy for non-resectable canine subcutaneous haemangiosarcoma

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