Primary Pulmonary Artery Intimal Sarcoma Case with Elevated Coagulation Markers

Sakai, Koshiro

doi:10.7860/jcdr/2017/23423.9609

Cited by 8 publications

(11 citation statements)

References 6 publications

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Section: Discussionmentioning

confidence: 99%

“…In that case, at the time of surgical removal, no thrombus was identified, leading the authors to hypothesize that the PAIS had been surrounded by thrombus which had then been rapidly dissolved by anticoagulation therapy. 11 A number of imaging characteristics have been identified which may assist in the diagnosis. CT angiography findings suggestive of PAIS include lobulated or polypoid filling defects, tumoural impaction, proximal lesions or heterogeneous attenuation.…”

Section: Discussionmentioning

confidence: 99%

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Pulmonary artery sarcoma: An important mimic of pulmonary embolism—Case reports and literature review

Tuft

Maheepala

Raguparan

et al. 2022

Respirology Case Reports

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Pulmonary artery intimal sarcoma (PAIS) is a rare malignancy which closely mimics acute or chronic pulmonary thromboembolism. There are clinical and radiological characteristics which may raise suspicion of this important differential diagnosis. These include disproportionately low d ‐dimer, troponin T or NT‐proBNP, as well as characteristic findings on CT pulmonary angiography such as the ‘wall eclipsing sign’ and an non‐dependent position of filling defects in the large arteries. Prompt diagnosis avoids inappropriate anticoagulation and facilitates early surgical management which may improve prognosis. There is emerging evidence of an effective treatment paradigm with surgical resection and adjuvant chemotherapy. We present two cases of PAIS diagnosed at a single centre within a 2‐year period. We review the literature and demonstrate the features at presentation in our cases which were suggestive of the diagnosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Pulmonary artery sarcoma: An important mimic of pulmonary embolism—Case reports and literature review

Tuft

Maheepala

Raguparan

et al. 2022

Respirology Case Reports

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“…The values are however lower in PPAS [8]. Elevation of coagulation markers in PPAS is thought to result from a thrombus or inflammation surrounding the tumor [11]. C-reactive protein levels are increased in PPAS more than chronic pulmonary thromboembolism cases.…”

Section: Discussionmentioning

confidence: 99%

Primary pulmonary artery sarcoma: A rare and overlooked differential diagnosis of pulmonary embolism. Clues to diagnosis

Al-Mehisen

Al‐Halees

Alnemri

et al. 2019

International Journal of Surgery Case Reports

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HighlightsPPAS is an aggressive malignant tumor that masquerades as PE leading to a delay in diagnosis.Limited data exist on the clinical presentation, diagnosis, and management of PPAS.Knowledge of the clinical and imaging characteristics of this tumor is of importance for clinicians and surgeons.Early definitive surgery may improve survival; early diagnosis aided by imaging studies improves surgical outcomes.

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“…Koshiro et al reported PAS could combine with abnormal coagulation-fibrinolysis system without DVT, and they speculated that the reason for it might be the long-term inflammatory response induced by PAS or a thrombus surrounding PSA. [13] Despite the rapid development of imaging technology, including CT and MRI, it is still unable to diagnose PSA clearly. [14] The chest enhanced CT or CTA of our patient only revealed massive filling defects, but it could distinguish from PSA or PE.…”

Section: Discussionmentioning

confidence: 99%

Primary pulmonary artery sarcoma with deep vein thrombosis

Li¹,

Liang

et al. 2019

Medicine

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Rationale: Pulmonary artery sarcomas (PAS) are easily misdiagnosed as thromboembolic disease of pulmonary arteries, because of rarity and presenting with nonspecific signs, symptoms, or imaging findings. Patient concerns: A 26-year-old man was admitted to the department of invasive technology with fever and dyspnea. Blood tests showed inflammatory activity, a slight increase of D-dimer and Fibrin Degradation Product. A chest enhanced computed tomography (CT) scanning revealed multiple filling defects occurred in the main trunk of both pulmonary arteries and branches of the left pulmonary artery Diagnoses: It was initially diagnosed with pulmonary embolism (PE) and deep vein thrombosis (DVT), but was eventually diagnosed with pulmonary artery sarcoma that was confirmed by biopsy. Interventions: The transcatheter thrombolysis therapy, inferior vena cava filter implantation, and operation were performed. Outcomes: The Organized mass was removed by the operation and was pathologically diagnosed as pulmonary artery sarcoma, the patient received postoperative chemotherapy according to the recommendation of oncology department. Lessons: Coagulation markers have been reported to differentiate PAS from PE, but this case suggested that PAS can be associated with DVT and abnormal coagulation-fibrinolysis system.

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Primary Pulmonary Artery Intimal Sarcoma Case with Elevated Coagulation Markers

Cited by 8 publications

References 6 publications

Pulmonary artery sarcoma: An important mimic of pulmonary embolism—Case reports and literature review

Pulmonary artery sarcoma: An important mimic of pulmonary embolism—Case reports and literature review

Primary pulmonary artery sarcoma: A rare and overlooked differential diagnosis of pulmonary embolism. Clues to diagnosis

Primary pulmonary artery sarcoma with deep vein thrombosis

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