Primary Pulmonary Choriocarcinoma: Case Report and Review of the Literature

Serno, J.; Zeppernick, Felix; Jäkel, Jörg; Schrading, Simone; Maass, Nicolaì; Meinhold‐Heerlein, Ivo; Bauerschlag, Dirk

doi:10.1159/000336784

Cited by 35 publications

(38 citation statements)

References 35 publications

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“…Nine patients had metastasis: Two cases with primary and metastatic sites were totally resected (one of whom died 54 months after diagnosis, the other of whom survived). Regarding the corresponding outcomes of primary lung choriocarcinoma, we observed a slight tendency toward complete resection followed by chemotherapy or close follow-up examinations, thereby providing patients with the best likelihood of survival 16. The results of the PUMCH cases suggest that the complete resection of the primary site and metastases played important roles in the treatment of males with PCC.…”

Section: Discussionmentioning

confidence: 80%

Clinical analysis of 13 males with primary choriocarcinoma and review of the literature

Jiang¹,

Xiang²,

Feng³

et al. 2014

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ObjectiveTo analyze the management and prognosis of primary choriocarcinoma (PCC) in male patients.MethodsThe clinical records of males with PCC who were treated at Peking Union Medical College Hospital between 1990 and 2012 were analyzed retrospectively. The literature regarding this clinical condition was also reviewed.ResultsThe median survival interval of the 13 patients treated at Peking Union Medical College Hospital was 54 months (range, 6–115 months), and the 1- and 3-year survival rates were 53.8% and 43.1%, respectively. All patients were treated with surgery; 12 were treated with combined chemotherapy. After including 100 cases found in the literature, for a total of 113 patients, the median survival interval was 10 months (range, 6.4–13.6 months). The testis was the most common primary site (36.2%). Most patients (70.9%) had metastatic lesions at diagnosis. Univariate and multivariate analyses revealed that longer median overall survival was significantly associated with patient age <34 years old (48 months vs 10 months, odds ratio [OR] =0.47, P=0.029), the presence of other histological components (54 months vs 11 months, OR =0.54, P=0.011), and combined chemotherapy and surgical treatments (14 months vs 2.5 months, OR =0.18, P=0.002).ConclusionPCC is an extremely rare disease among men, and its prognosis is much worse than that of gestational choriocarcinoma. The complete resection of the primary site and metastases followed by chemotherapy seems to provide patients with the best chance at survival. Furthermore, additional chemotherapy cycles might facilitate better progress.

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Section: Discussionmentioning

confidence: 80%

Clinical analysis of 13 males with primary choriocarcinoma and review of the literature

Jiang¹,

Xiang²,

Feng³

et al. 2014

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“…These are similar to those seen in singleton complete molar pregnancies and include vaginal bleeding (23.4% in the first trimester [9]), excessive uterine enlargement (51%), theca-lutein ovarian cyst (46%), toxemia (27%), hyperemesis (26%), hyperthyroidism (26%) and respiratory insufficiency (2%) [10]. There has even been a report of a primary pulmonary choriocarcinoma [11]. Some authors have found the risk of severe preeclampsia to be elevated (25.8%) in CHMTF [12,13], but others have not found any significant differences with respect to singleton complete molar pregnancies [14].…”

Section: Discussionmentioning

confidence: 76%

Uterine Rupture in Twin Pregnancy with Normal Fetus and Complete Hydatidiform Mole

Sánchez-Ferrer¹,

Hernández-Martínez²,

Machado-Linde³

et al. 2013

Gynecol Obstet Invest

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We describe a rare case of complete hydatidiform mole with twin live fetus (CHMTF) confirmed by histopathology, flow cytometry and polymerase chain reaction techniques. No malformations were observed, fetal karyotype was normal and β-human chorionic gonadotropin levels were high (>100,000 IU/ml). The patient was informed of the risks and decided to continue with the pregnancy, but at week 15, she had to undergo hysterectomy due to uterine rupture. She subsequently developed persistent trophoblastic disease (PTD) with pulmonary metastases that required treatment with polychemotherapy. Patients with CHMTF should be informed of all known risks, including the considerable risk of PTD, which is similar to or, even higher than that associated with a singleton complete mole. The risk does not appear to be increased by continuing the pregnancy. Because so few series have been published, there is a lack of evidence-based clinical management guidelines. To our knowledge, this is the first report of uterine rupture in CHMTF.

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“…Primary pulmonary choriocarcinoma is extremely rare and 33 cases, including the current case, have been reported so far and 24 cases underwent surgical treatment [1][2][3][4]. The fact that nine cases have been diagnosed at autopsy reflects aggressive nature of this tumor.…”

Section: Discussionmentioning

confidence: 91%

A case of primary pulmonary choriocarcinoma successfully treated by surgery

Kamata

Sakurada

Sato

et al. 2016

Gen Thorac Cardiovasc Surg

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Primary pulmonary choriocarcinoma is a very rare tumor and eventually diagnosed by pulmonary resection. A poor prognosis has been reported for this disease, but appropriate treatment has not been established. Here, we report the successful surgical treatment for a primary pulmonary choriocarcinoma. A 70-year-old male presented with cough and a 3.8-cm solid tumor was detected in the right upper lobe of the lung on CT scan. Results of an open lung biopsy indicated carcinoma with indeterminate histological subtype. Right upper lobectomy was performed and the permanent pathological diagnosis was choriocarcinoma. Right after surgery, systemic and genital screening was performed by urologist, but no abnormal findings were observed. Elevation of serum β-hCG was confirmed at the same time and the value dropped within normal range in 2 months. According to diagnosis criteria, we reached final diagnosis of primary pulmonary choriocarcinoma. The patient has been alive with no recurrence for 2 years after surgery.

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Primary Pulmonary Choriocarcinoma: Case Report and Review of the Literature

Cited by 35 publications

References 35 publications

Clinical analysis of 13 males with primary choriocarcinoma and review of the literature

Clinical analysis of 13 males with primary choriocarcinoma and review of the literature

Uterine Rupture in Twin Pregnancy with Normal Fetus and Complete Hydatidiform Mole

A case of primary pulmonary choriocarcinoma successfully treated by surgery

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