Primary pulmonary choriocarcinoma in a male

Hadgu, Akberet; Tindni, Arshdeep; Panda, Mukta

doi:10.1136/bcr.02.2010.2712

Cited by 13 publications

(9 citation statements)

References 12 publications

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“…Because most patients are diagnosed at an advanced stage of tumor metastasis, certain authors believe that all patients should receive chemotherapy. Adjuvant chemotherapy with two to four cycles of bleomycin, etoposide, and cisplatin (ie, PEB protocol) has been recommended for patients with ovarian choriocarcinomas 4,16. Most of the 13 PUMCH patients received chemotherapy with actinomycin D, etoposide, methotrexate, cyclophosphamide, and vincristine (ie, EMA/CO protocol); the median number of cycles was seven (range, 3–27 cycles).…”

Section: Discussionmentioning

confidence: 99%

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Clinical analysis of 13 males with primary choriocarcinoma and review of the literature

Jiang¹,

Xiang²,

Feng³

et al. 2014

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ObjectiveTo analyze the management and prognosis of primary choriocarcinoma (PCC) in male patients.MethodsThe clinical records of males with PCC who were treated at Peking Union Medical College Hospital between 1990 and 2012 were analyzed retrospectively. The literature regarding this clinical condition was also reviewed.ResultsThe median survival interval of the 13 patients treated at Peking Union Medical College Hospital was 54 months (range, 6–115 months), and the 1- and 3-year survival rates were 53.8% and 43.1%, respectively. All patients were treated with surgery; 12 were treated with combined chemotherapy. After including 100 cases found in the literature, for a total of 113 patients, the median survival interval was 10 months (range, 6.4–13.6 months). The testis was the most common primary site (36.2%). Most patients (70.9%) had metastatic lesions at diagnosis. Univariate and multivariate analyses revealed that longer median overall survival was significantly associated with patient age <34 years old (48 months vs 10 months, odds ratio [OR] =0.47, P=0.029), the presence of other histological components (54 months vs 11 months, OR =0.54, P=0.011), and combined chemotherapy and surgical treatments (14 months vs 2.5 months, OR =0.18, P=0.002).ConclusionPCC is an extremely rare disease among men, and its prognosis is much worse than that of gestational choriocarcinoma. The complete resection of the primary site and metastases followed by chemotherapy seems to provide patients with the best chance at survival. Furthermore, additional chemotherapy cycles might facilitate better progress.

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Section: Discussionmentioning

confidence: 99%

“…In men, the most common primary site is the testis. 1 When the primary tumor is extragonadal, it can occur in the mediastinum, 2 retroperitoneum, 3 lung, 4 brain, 5 or digestive tract. 6 Because its clinical symptoms are atypical, early diagnosis is difficult.…”

Section: Introductionmentioning

confidence: 99%

Clinical analysis of 13 males with primary choriocarcinoma and review of the literature

Jiang¹,

Xiang²,

Feng³

et al. 2014

OTT

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“…However, the best time for surgery is always missed when carcinoma is identified due to the high degree of malignancy and early bleeding. Thereafter, the only option left is conservative treatment such as chemotherapy, which includes treatment with drugs such as etoposide, cisplatinum, methotrexate, actinomycin D, bleomycin, 5-fluorouracil, VP-16, cyclophosphamide and vincristine (10)(11)(12). However, these drugs are only partially effective, as the majority of patients succumb within a short follow-up time.…”

Section: Discussionmentioning

confidence: 99%

“…The present patient serves as a typical example to this effect, since multi-organ metastasis was observed, the symptoms were only displayed for 4 days prior to admission and the patient succumbed after the fourth day of admission. Similarly, based on literature reviews, the majority of patients succumb to organ bleeding, respiratory failure, hemorrhagic shock, disseminated intravascular coagulation and abdominal compartment syndrome (11). The occurrence of liver or brain metastases is associated with a worse prognosis (14).…”

Section: Discussionmentioning

confidence: 99%

Choriocarcinoma of unknown origin with multiple organ metastasis and cerebral hemorrhage: A case report and literature review

et al. 2016

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“…However, some cases have been reported to emerge in the lung, gastrointestinal tract, brain, and liver. In the literature, only 29 cases of primary choriocarcinoma in lung have been reported in males, including 25 cases of choriocarcinoma, [1,3–11,13–19,21–22,24–26] 3 cases of choriocarcinoma combined with adenocarcinoma, [12,20,23] and 1 case of mediastinopulmonary choriocarcinoma, [2] which is even rarer and has a very poor prognosis compared to its counterpart in the midline structures according to the literature. Primary pulmonary choriocarcinoma (PPC) in males is easy to misdiagnose or delay the diagnosis; therefore, a potentially curative chemotherapy or surgery may also be delayed.…”

Section: Introductionmentioning

confidence: 99%

Primary pulmonary choriocarcinoma in a male that was successfully diagnosed and treated

et al. 2016

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Introduction:Primary pulmonary choriocarcinoma (PPC) is extremely rare, especially in males. It is characterized by a poor response to therapy and shortened survival times. Here, we report a successful diagnosis and modified treatment for PPC in a male and a review of the literature.Case presentation:This case report describes a 67-year-old male who was discovered to have a left pulmonary mass. The patient underwent a pulmonary lobectomy. Pathological examination showed a poorly biphasic differential tumor. Immunostaining displayed that beta-human chorionic gonadotropin (β-HCG), CD10, and GATA3 were positive, and the increase of postoperative serum β-HCG secretion was also confirmed. Systemic and genital screening was performed, but other abnormal findings were not observed. The diagnosis of PPC was confirmed. Then, the patient received 4 cycles of modified chemotherapy according the condition of his body. The patient has been alive for >13 months without recurrence, and the level of serum β-HCG has already decreased to normal. In addition to reporting this case, we have also summarized the similar previously published cases.Conclusions:Currently, there is no standard treatment for PPC. A rapid and correct diagnosis is necessary. Surgery and modified chemotherapy, based on the physical condition of the patient, may currently be the best therapy for PPC.

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Primary pulmonary choriocarcinoma in a male

Cited by 13 publications

References 12 publications

Clinical analysis of 13 males with primary choriocarcinoma and review of the literature

Clinical analysis of 13 males with primary choriocarcinoma and review of the literature

Choriocarcinoma of unknown origin with multiple organ metastasis and cerebral hemorrhage: A case report and literature review

Primary pulmonary choriocarcinoma in a male that was successfully diagnosed and treated

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