Primary pulmonary cryptococcosis

Hatcher, Charles R.; Sehdeva, Jagjit S.; Waters, William C.; Schulze, Victor E.; Logan, William D.; Symbas, Panagiotis N.; Abbott, Osler A.

doi:10.1016/s0022-5223(19)42273-3

Cited by 31 publications

(10 citation statements)

References 33 publications

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“…The high frequency of these lesions is consistent with that reported by other studies [ 8 , 11 , 12 , 14 , 15 ]. The lesions were located predominantly in the lower lung (62.5%) rather than in the middle (18.8%) or upper lung (37.5%), which was also noted in other studies [ 11 , 16 – 18 ], and were found mainly in the right (81.3%) rather than the left (50.0%) lung in most patients. Most lesions were found in a single lobe (62.5%), and no lesions were present in 4 or more lobes.…”

Section: Discussionsupporting

confidence: 86%

Correlation between Clinical Characteristics and Chest Computed Tomography Findings of Pulmonary Cryptococcosis

et al. 2015

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Objective. The aim of this study was to review HIV-negative patients with pulmonary cryptococcosis to analyze the correlations between clinical characteristics and chest computed tomography (CT) findings. Methods. We retrospectively analyzed medical records of 16 HIV-negative patients with pulmonary cryptococcosis diagnosed at our institution, and clinical characteristics of the patients with nodules or masses without ground-glass attenuation (GGA)/consolidation type were compared with those of patients with inclusive GGA or consolidation type. Results. Host status was immunocompromised (81.2%) in most of the patients, and 6 (37.5%) were asymptomatic. The most frequent radiologic abnormalities on chest CT scans were one or more nodules (87.5%), GGA (37.5%), and consolidations (18.8%). Most lesions were located in the lower lung. Levels of hemoglobin and platelets were significantly lower in patients with inclusive GGA or consolidation type. Although the differences were not significant, patients with inclusive GGA or consolidation type tended to have a C-reactive protein level of ≥1.0 mg/dL. Conclusion. If a patient with anemia and thrombocytopenia shows GGA or consolidation in the lung, pulmonary cryptococcosis should be given careful consideration.

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Section: Discussionsupporting

confidence: 86%

Correlation between Clinical Characteristics and Chest Computed Tomography Findings of Pulmonary Cryptococcosis

et al. 2015

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“…5,11,12 The nodules may vary in size, ranging from 0.5 to 4 cm in diameter. 12,13 Lesions were most commonly distributed in the lower lung, followed by upper the field. 5,11,13,14 Similarly, Chu HQ et al 14 found the predominance of lesions in the lower lobes.…”

Section: Discussionmentioning

confidence: 99%

“…12,13 Lesions were most commonly distributed in the lower lung, followed by upper the field. 5,11,13,14 Similarly, Chu HQ et al 14 found the predominance of lesions in the lower lobes. In the present study, the nodules presented in peripheral and subpleural regions, as described previously.…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, the nodules presented in peripheral and subpleural regions, as described previously. [11][12][13][14][15][16] Less frequent radiographic features include segmental or lobar pneumonia, cavi- 12,17 Treatment of pulmonary cryptococcosis depends on the host's immune status and the anatomical site of involvement. 6,18,19 When the patient is immunocompromised or has dissemination of infection to the CNS or other organs, active therapy is warranted.…”

Section: Discussionmentioning

confidence: 99%

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Pulmonary cryptococcosis in non-AIDS patients

Liu²,

Huang³

et al. 2009

CIM

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Clin Invest Med 2009; 32 (1): E70-E77. AbstractPurpose: To clarify the clinical features and imaging characteristics of non-AIDS patients with pulmonary cryptococcosis. Methods: We retrospectively collected 15 HIV-negative patients with pathology-proved pulmonary cryptococcosis from Sep1992 to Jan 2008. Their medical records and radiological data were reviewed and analyzed. Results: Only one patient was asymptomatic.Thirteen patients were immunocompetent and two were immunosuppressed. Three patients had associated cryptococcosis meningitis. The most common radiographic abnormalities were multiple pulmonary nodules or masses, seen in 8 and 5 cases of patients respectively. 14 patients received specific therapy for Cryptococcus neoformans. Two patients died. In the 11 patients with isolated pulmonary cryptococcosis, treatment consisted of fluconazole alone (n=7), in combination with amphotericin B (n=2), and both 5flucytosine and amphotericin B (n=2). For the other 2 patients with cryptococcosis meningitis, one was treated with amphotericin B alone and the other with fluconazole combined with amphotericin B and 5-flucytosine. Conclusions: Non-AIDS patients might also susceptible to cryptococcosis infection. Histological examination is the principal method of diagnosis. The most common CT findings are solitary or multiple nodules with or without cavitation in the subpleural areas of the lung.

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“…The most common radiographic manifestations of pulmonary cryptococcosis consist of single or multiple pulmonary nodules, segmental or lobar consolidation or a reticulonodular pattern of opacities. 11,12 Associated features include cavitation, lymphadenopathy and pleural effusion. 13 …”

Section: Discussionmentioning

confidence: 99%

Cryptococcal pneumonia: the great mimicker

et al. 2017

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Cryptococcal pneumonia is a fungal infection caused by Cryptococcus neoformans predominantly in immunosuppressed individuals and rarely in the immunocompetent population. In this study, we describe the varied radiological presentations in three patients, both immunosuppressed and immunocompetent individuals. The varied imaging presentations pose a great challenge for the radiologist and the clinician. The imaging findings mimic other diseases and it might make the diagnosis difficult purely on radiological features alone. Hence, image-guided biopsies and further evaluation are essential for confirmation of diagnosis.

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Primary pulmonary cryptococcosis

Cited by 31 publications

References 33 publications

Correlation between Clinical Characteristics and Chest Computed Tomography Findings of Pulmonary Cryptococcosis

Correlation between Clinical Characteristics and Chest Computed Tomography Findings of Pulmonary Cryptococcosis

Pulmonary cryptococcosis in non-AIDS patients

Cryptococcal pneumonia: the great mimicker

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