Primary Pulmonary Hypoplasia

George, P.S.; Cr, Handorf; Ea, Suttle

doi:10.1097/00007611-198107000-00030

Cited by 3 publications

(2 citation statements)

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“…Very few cases of isolated bilateral pulmonary hypoplasia have been reported in which none of the known underlying causes were found (2,7,8,11,14,15,18,22). Radiographic studies have suggested that non-lethal pulmonary hypoplasia may be a more common cause of respiratory insufficiency during the immediate postnatal period than hitherto thought (14).…”

Section: Discussionmentioning

confidence: 99%

“…Radiographic studies have suggested that non-lethal pulmonary hypoplasia may be a more common cause of respiratory insufficiency during the immediate postnatal period than hitherto thought (14). Some of the reported cases of isolated pulmonary hypoplasia have occurred together with a number of minor anomalies (2), some together with polyhydramnios (1 8), while only a very few cases were without any other malformation (7,8,11). Some of the cases of solitary or primary lung hypoplasia showed evidence of immaturity (1 8).…”

Section: Discussionmentioning

confidence: 99%

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Lung hypoplasia – a possible teratogenic effect of valproate

Janas¹,

Arrøe

Hansen³

et al. 1998

APMIS

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Three cases of lung hypoplasia occurring in two siblings and in an unrelated child are reported. All three cases had been exposed to valproate in utero. The two female siblings had no other malformations, whereas the third female had a number of defects consistent with the fetal valproate syndrome. Thus, none of the known major causes of lung hypoplasia was present in any of the three cases. It is discussed whether pulmonary hypoplasia may be a separate disease entity, or caused by prenatal exposure to valproate.

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