Primary Pulmonary MALT Lymphoma Presenting as Non-Resolving Pneumonia

Iftikhar, Asma; Magh, Albert; Cheema, M.; Thappa, Sarah; Sahni, Sonu; Karbowitz, Stephen

doi:10.5603/arm.2017.0033

Cited by 10 publications

(7 citation statements)

References 11 publications

(16 reference statements)

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“…Our findings were in agreement with previous observations as well 22–24 . Consequently, an indolent clinical course and several highly suspected signs at CT (including air bronchogram sign, angiogram sign, well‐marginated halo sign, coarse spiculate with different lengths, and peribronchovascular thickening) might suggest a high possibility of pulmonary MALToma, thus avoiding unnecessary immediate intervention 25 …”

Section: Discussionsupporting

confidence: 93%

“…Although it is difficult to diagnose pulmonary MALToma merely depending on clinical and radiological manifestations, 25,26 in this investigation, we correlated radiologic with pathologic findings and identified several hints suggesting a high possibility of this rare disease, which might provide valuable information for treatment before pathological diagnosis. However, this study has several limitations.…”

Section: Discussionmentioning

confidence: 91%

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Pulmonary mucosa‐associated lymphoid tissue lymphoma: CT findings and pathological basis

Zhao

et al. 2021

Journal of Surgical Oncology

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Background Pulmonary mucosa‐associated lymphoid tissue lymphoma (MALToma) is the most frequent subset of primary pulmonary lymphoma. This study aimed to identify radiologic characteristics of pulmonary MALToma based on computed tomography (CT) observations and pathologic features, and further investigate its prognosis. Methods Sixty‐six patients (55.4 ± 10.9 years; 51.5% male) diagnosed as pulmonary MALToma by pathology were retrospectively enrolled. According to distributions and features of lesions shown on CT, patients were divided into three patterns, including single nodular/mass, multiple nodular/mass, and pneumonia‐like consolidative. Results Variety of the location and extent of the lymphomatous infiltration accounted for different characteristics demonstrated at CT. The pneumonia‐like consolidative pattern was the most frequent pattern observed in 42 patients (63.6%), followed by single nodular/mass (21.2%) and multiple nodular/mass (15.2%). CT features included air bronchogram (72.7%), well‐marginated halo sign (53.0%), coarse spiculate with different lengths (72.7%), angiogram sign (77.1% of 35 patients), peribronchovascular thickening (48.5%), irregular cavitation (16.7%) and pulmonary cyst (7.6%). The estimated 5‐year cumulative overall survival rate of pulmonary MALToma was 100.0%. Conclusions Pulmonary MALToma demonstrates several characteristics at CT. Identification of the significant pulmonary abnormalities of this indolent disease entity might be helpful for early diagnosis and optimal treatment.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 91%

Pulmonary mucosa‐associated lymphoid tissue lymphoma: CT findings and pathological basis

Zhao

et al. 2021

Journal of Surgical Oncology

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“…Similar to lobar pneumonia, consolidation pattern can be easily misdiagnosed as pneumonia. 6,7 Pulmonary MALT lymphoma is usually treated with chemotherapy, immunotherapy or surgery, while lobar pneumonia is usually treated with antibiotics. 8 Based on the fact, it is important to distinguish MALT lymphoma from lobar pneumonia accurately in order to institute appropriate treatment to improve their prognosis.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of HRCT for the Differential Diagnosis of Pneumonia-Like Consolidation Pattern of Pulmonary MALT Lymphoma from Lobar Pneumonia

Qiu¹,

Chen²,

Zhang³

et al. 2021

CMAR

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Purpose: To assess the performance of high-resolution computed tomography (HRCT) in discriminating the consolidation pattern of pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma from lobar pneumonia. Patients and Methods: This retrospective study comprised 26 patients with pathologically confirmed consolidation pattern of pulmonary MALT lymphoma (12 men and 14 women; mean age, 59.4±12.1 years) and 36 patients with lobar pneumonia confirmed by body fluids or respiratory secretion culture (16 men and 20 women; mean age, 41.8±26.3 years). Two radiologists independently evaluated the CT images. The effectiveness of these variables in distinguishing lobar pneumonia from MALT lymphoma was analyzed using logistic regression analysis. Results:The average age of lobar pneumonia patients was younger than that of MALT lymphoma patients (p=0.002). The respiratory symptom was more common in lobar pneumonia than MALT lymphoma (p=0.002). Signs of bronchiectasis within the consolidation and bulging of interlobar fissure occurred significantly more often in MALT lymphoma than pneumonia (69.2% vs 11.1%, p<0.0001; 46.2% vs 19.4%, p=0.024). We used the predictors with p<0.05 (age, respiratory symptoms, bronchiectasis, and bulging of interlobar fissure) to construct a logistic regression model. The area under curve (AUC), negative predictive value (NPV), positive predictive value (PPV), sensitivity, specificity, and accuracy were 0.891, 84.21%, 83.33%, 88.89%, 76.92%, and 83.87% for discriminating lobar pneumonia from MALT lymphoma. Conclusion: Middle-aged, presence of mild clinical symptoms, bronchiectasis and bulging of the interlobar fissure on chest CT images are potential markers to distinguish pulmonary MALT lymphoma from lobar pneumonia.

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“…It is not related to smoking or occupational exposure, and the median age at the time of diagnosis is about 50 [11 , 16] . It is a challenging diagnosis due to its indolent nature, and non-specific clinical and radiological findings [17] .…”

Section: Discussionmentioning

confidence: 99%