Primary Pulmonary Manifestation of Hodgkin’s Disease

Schee, Alexandr; Dinkla, B.A.; Knapen, A. van

doi:10.1159/000195833

Cited by 13 publications

(6 citation statements)

References 4 publications

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“…We have performed a literature search for reported cases of PPHL. Table summarizes the cases reported since 1990 and includes only cases evaluated with CT and/or PET scans, and those that involved surgical resection of the lung lesion and mediastinal lymph nodes to pathologically confirm they were truly cases of PPHL . A total of 11 cases are included.…”

Section: Discussionmentioning

confidence: 99%

“…In patients with PPHL, the addition of radiation and/or chemotherapy after complete surgical resection of the tumor appears to reduce the risk of recurrence. Among 37 cases reported in the literature when complete surgical resections were performed, adjuvant treatment was not given in five cases . Only one of these five patients was recurrence‐free at last follow‐up.…”

Section: Discussionmentioning

confidence: 99%

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Primary pulmonary classical Hodgkin lymphoma: A case report

Schild

Wong

Valdez

et al. 2014

Journal of Surgical Oncology

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Primary pulmonary Hodgkin lymphoma (PPHL) is a rare entity. Most reported cases occurred before the availability of PET scan for accurate staging of the disease. We report a case of PPHL for which PET/CT scan was used and surgery was performed to confirm the diagnosis. A review of cases of PPHL since 1990 suggests that adjuvant chemotherapy and/or radiation therapy after surgical resection of the lung lesions achieve better disease control than surgical resection alone. J. Surg. Oncol. 2014 110:341–344. © 2014 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Primary pulmonary classical Hodgkin lymphoma: A case report

Schild

Wong

Valdez

et al. 2014

Journal of Surgical Oncology

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“…Involvement of the lung parenchyma is relatively rare in Hodgkin disease (10,11) and accounts for 5.9%-11.6% of cases (6,7,12). It is bilateral in about 4.3% of cases (7).…”

Section: Lungsmentioning

confidence: 99%

“…Bronchoscopy may be used to confirm endobronchial disease. The least common parenchymal manifestation is interstitial infiltration representing disease along the lymphatic routes (6)(7)(8)(10)(11)(12)(13)(14)(15)(17)(18)(19).…”

Section: Lungsmentioning

confidence: 99%

Extranodal Hodgkin Disease: Spectrum of Disease

Guermazi¹,

Brice²,

Kerviler³

et al. 2001

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Extranodal lesions in Hodgkin disease may develop and spread to virtually any organ system, simulating other neoplastic or infectious diseases. It is important to determine whether extranodal involvement represents a primary manifestation or dissemination of systemic disease, which has a poorer prognosis. Computed tomography (CT) is the preferred modality, although ultrasonography and magnetic resonance (MR) imaging may also be helpful. CT is superior to conventional radiography in assessing chest disease, although MR imaging is more sensitive than CT in detecting chest wall involvement. CT is preferred for evaluating hepatic lymphoma and has proved particularly valuable in diagnosing gastric lymphoma and detecting renal or perirenal masses. CT and MR imaging are equally effective in detecting brain Hodgkin disease; however, the latter is superior in the detection of extracerebral tumor deposits in the subdural or epidural space. MR imaging is also preferred for evaluating meningeal and spinal cord involvement. Both MR imaging and CT allow excellent assessment of bone texture and accurate analysis of tumoral bone invasion, but MR imaging is superior in demonstrating bone marrow infiltration, and CT is superior in delineating the extent of cortical bone destruction. In the future, metabolic positron emission tomography may provide more information about extranodal lymphoma than do the current imaging modalities.

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“…A database search identified 101 cases between 1990 and 2020 (Table 1 ). 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 Most cases were diagnosed by surgical biopsy (85 cases), followed by CT‐guided biopsy (eight cases) and TBB (four cases).…”

Section: Case Reportmentioning

confidence: 99%

Diagnostic utility of transbronchial biopsy for Hodgkin's lymphoma: A case study

et al. 2021

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Lung lesions of Hodgkin's lymphoma (HL) are rare and difficult to diagnose by nonsurgical biopsy. We herein present the case of a 72-year-old Japanese male who presented with accumulation of lung infiltrates and masses bilaterally on the lungs for 3 years. Although transbronchial lung biopsy (TBB) and computed tomographyguided biopsy were conducted several times, his diagnosis remained inconclusive. On further deterioration of lung lesions, the patient was transferred to our hospital. Positron emission tomography revealed increased accumulation in the bilateral lungs and right supraclavicular lymph nodes. Surgical biopsy of the lymph node was performed. He was finally diagnosed with HL and underwent chemotherapy with doxorubicin, vinblastine, dacarbazine, and brentuximab vedotin. After chemotherapy, the lung lesion showed significant regression. A literature review indicated that the diagnostic success rate of TBB was low (18.5%) in cases of lung lesions in HL.

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Primary Pulmonary Manifestation of Hodgkin’s Disease

Cited by 13 publications

References 4 publications

Primary pulmonary classical Hodgkin lymphoma: A case report

Primary pulmonary classical Hodgkin lymphoma: A case report

Extranodal Hodgkin Disease: Spectrum of Disease

Diagnostic utility of transbronchial biopsy for Hodgkin's lymphoma: A case study

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