Primary pulmonary mucosa-associated lymphoid tissue lymphoma computed tomography findings: a case report

Abstract

Primary pulmonary non-Hodgkin's lymphoma is a very rare neoplasm. It is most frequently represented by the mucosa-associated lymphoid tissue type. We describe a case of a 67-year-old woman who presented with fatigue, mild dyspnea, and consolidation on chest radiograph. The diagnosis of non-Hodgkin's lymphoma was established by transbronchial biopsy, and chemotherapy was then started. The patient was treated with 6 cycles of chemotherapy. She had good response to therapy and no progression of the disease was observed during a 4-year follow-up period. The clinical, radiological and histopathological features are described. This entity has an indolent course, good response to therapy and favorable prognosis. However, despite being an incidental radiological finding in a third of cases, this disease remains highly underdiagnosed.

Primary pulmonary lymphoma: About five cases and literature review

“…At pulmonary auscultation, crackles are present in less than 20% of cases. [ 3 ] The radiographic findings are nonspecific also and include solitary nodule, multiple ill-defined nodules, consolidated mass with air bronchograms, pleura effusions, atelectasis, and cavities. [ 4 ] PPL originate frequently from the B cell-lineage which is represented most commonly by marginal zone B-cell lymphoma of MALT of the bronchus that is thought to be acquired as a result of chronic antigenic stimulation such as smoking, autoimmune disease, or infection.…”

“…[ 2 ] This definition includes: Multifocal mucosa-associated lymphoid tissue (MALT) NHL; pulmonary lymphoma with satellite nodes (hilar or mediastinal); low-grade B-cell PPL; high-grade B-cell PPL. [ 3 ] Although there are several treatment options such as tumor resection, radiation and chemotherapy, the therapeutic consensus has not been clearly established. The prognosis is overall good especially in low-grade disease.…”