Primary pulmonary plasmacytoma accompanied by overlap syndrome: A case report and review of the literature

Zhou, Yi; Wang, Xiaohong; Meng, Shuang-Shuang; Wang, Huichao; Li, Yuxia; Xu, Rui; Lin, Xiaoqing Diana

doi:10.12998/wjcc.v8.i20.4999

Cited by 5 publications

(6 citation statements)

References 39 publications

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“…In the present study, we encountered an extremely rare case of primary lung plasmacytomas without involving bone marrow. According to the classification of the Wilshaw method ( 4 ): Stage I, the tumour is confined to the primary site; stage II, the tumour has invaded local lymph nodes; and stage III, there are obvious widespread metastases. Therefore, in this case, the tumor should be classified as stage I.…”

Section: Discussionmentioning

confidence: 99%

“…The feature of Castleman disease is multiple concentric rings of mantle zone lymphocytes encircling atretic follicles. However, CD 38 and CD 138 are indicative of the diagnosis of plasmacytoma, especially CD138 ( 2 , 4 ). In most circumstances, features of PPP tumor cells are positive for CD138, CD38, CD45, PC, EMA, and CD20, while negative for CD15.…”

Section: Discussionmentioning

confidence: 99%

“…In most circumstances, features of PPP tumor cells are positive for CD138, CD38, CD45, PC, EMA, and CD20, while negative for CD15. In a few cases, CK and EMA are positive, but negative for CD45 ( 4 ).…”

Section: Discussionmentioning

confidence: 99%

“…Melphalan and prednisone are commonly used chemotherapy scheme ( 21 , 22 ). Chemotherapy is considered in patients with tumors larger than 5cm ( 4 ). Taking into account, the size of the primary lesion without local infiltration or distant metastasis.…”

Section: Discussionmentioning

confidence: 99%

“…Primary pulmonary plasmacytoma (PPP) is an extremely rare variant of EMP. In a comprehensive literature search reviewing patients with PPP, only 16 reports were found (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) summarized in Table 1). Here, we present an extremely unusual presentation as a pulmonary mass and without bone marrow involvement.…”

Section: Introductionmentioning

confidence: 99%

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Solitary extramedullary plasmacytoma in the lung misdiagnosed as lung cancer: A case report and literature review

et al. 2022

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BackgroundExtramedullary plasmacytoma (EMP) is an extremely rare kind of soft tissue plasma cell neoplasm without bone marrow involvement or other systemic characteristics of multiple myeloma. Primary pulmonary plasmacytoma (PPP), with no specific clinical manifestations, is an exceedingly rare type of EMP. Because of its complexity, PPP is often difficult to diagnose. Computed tomography-guided percutaneous core needle biopsy (CT-guided PCNB) has been shown to have high sensitivity, specificity and accuracy for characterization of pulmonary lesion, particularly if malignancy is suspected. Here we presented a rare case of PPP diagnosed with CT-guided PCNB.Case presentationA 78-year-old female smoker who visited our outpatient clinic for a mass in the left lower lobe of the lung. Pathological based on CT-guided PCNB yielded a PPP with no lymph node or other distant metastasis.ConclusionsExtramedullary plasmacytoma should be considered in the differential diagnosis of a pulmonary mass.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Solitary extramedullary plasmacytoma in the lung misdiagnosed as lung cancer: A case report and literature review

et al. 2022

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A Rare Case of Solitary Endobronchial Plasmacytoma Presented With Complete Airway Obstruction: A Case Report

Banat,

Abukhalaf,

Faqiat

et al. 2024

Journal of Investigative Medicine High Impact Case Reports

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This case report presents a rare instance of solitary endobronchial plasmacytoma in a 58-year-old male, who had progressively worsening shortness of breath and a productive cough. The patient, who had a smoking history, was found to have a large, hypervascular mass completely obstructing the right main bronchus, confirmed as a plasma cell tumor via endoscopic biopsy. Further diagnostic imaging, including positron emission tomography-computed tomography (PET-CT) and chest CT, revealed a mass measuring 1.7 cm with abnormal fluorodeoxyglucose (FDG) uptake. The bone marrow biopsy ruled out multiple myeloma. The patient underwent challenging endoscopic debulking of the tumor, although margins were not well defined due to its size. Post-operatively, the patient showed significant symptomatic improvement and was discharged home on post-operative day 4. Two months after the procedure, follow-up with a chest CT scan and bronchoscopy showed no evidence of residual tumor or local recurrence, and the patient reported significant respiratory improvement. The literature review revealed that extramedullary plasmacytoma (EMP) is uncommon and often occurs in the upper aerodigestive tract. The diagnostic workup generally involves histopathological analysis, bronchoscopy, and imaging studies. Treatment is tailored to the patient’s condition and the characteristics of the tumor. This case underscores the need for a high index of suspicion and comprehensive diagnostic evaluation of patients presenting with obstructive bronchial mass. Furthermore, it highlights the importance of considering endobronchial plasmacytoma in the differential diagnosis of obstructive bronchial masses and the value of early intervention in achieving favorable outcomes. Regular follow-up is crucial to monitor recurrence and ensure ongoing patient well-being.

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Stepwise diagnostic algorithm for high-attenuation pulmonary abnormalities on CT

Fukuda,

Egashira,

Ueno

et al. 2023

Insights Imaging

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High-attenuation pulmonary abnormalities are commonly seen on CT. These findings are increasingly encountered with the growing number of CT examinations and the wide availability of thin-slice images. The abnormalities include benign lesions, such as infectious granulomatous diseases and metabolic diseases, and malignant tumors, such as lung cancers and metastatic tumors. Due to the wide spectrum of diseases, the proper diagnosis of high-attenuation abnormalities can be challenging. The assessment of these abnormal findings requires scrutiny, and the treatment is imperative. Our proposed stepwise diagnostic algorithm consists of five steps. Step 1: Establish the presence or absence of metallic artifacts. Step 2: Identify associated nodular or mass-like soft tissue components. Step 3: Establish the presence of solitary or multiple lesions if identified in Step 2. Step 4: Ascertain the predominant distribution in the upper or lower lungs if not identified in Step 2. Step 5: Identify the morphological pattern, such as linear, consolidation, nodular, or micronodular if not identified in Step 4. These five steps to diagnosing high-attenuation abnormalities subdivide the lesions into nine categories. This stepwise radiologic diagnostic approach could help to narrow the differential diagnosis for various pulmonary high-attenuation abnormalities and to achieve a precise diagnosis.Critical relevance statement Our proposed stepwise diagnostic algorithm for high-attenuation pulmonary abnormalities may help to recognize a variety of those high-attenuation findings, to determine whether the associated diseases require further investigation, and to guide appropriate patient management.Key points• To provide a stepwise diagnostic approach to high-attenuation pulmonary abnormalities.• To familiarize radiologists with the varying cause of high-attenuation pulmonary abnormalities.• To recognize which high-attenuation abnormalities require scrutiny and prompt treatment. Graphical Abstract

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Primary pulmonary plasmacytoma accompanied by overlap syndrome: A case report and review of the literature

Cited by 5 publications

References 39 publications

Solitary extramedullary plasmacytoma in the lung misdiagnosed as lung cancer: A case report and literature review

Solitary extramedullary plasmacytoma in the lung misdiagnosed as lung cancer: A case report and literature review

A Rare Case of Solitary Endobronchial Plasmacytoma Presented With Complete Airway Obstruction: A Case Report

Stepwise diagnostic algorithm for high-attenuation pulmonary abnormalities on CT

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