Primary Pure Non-Gestational Ovarian Choriocarcinoma: A Case Report

Abstract

Introduction: Pure non-gestational ovarian choriocarcinoma is a rare malignant condition with aggressive behavior. The tumor arises from germ cells of ovarian. Few cases have been reported in the literature. We present a case of pure ovarian choriocarcinoma with disseminated tumor in pelvic. Case Presentation: A 16-year-old girl was referred to Ghaem hospital, Mashhad University of Medical Sciences, Mashhad, Iran in April 2016 with acute abdominal pain, abdomino pelvic mass and vaginal bleeding. In addition, an extremely high level of sub unit of human chorionic gonadotropin β-hCG was detected. Based on the emergency condition, she underwent laparotomy and left salpingo-oophorectomy with suboptimal resection of the tumor. Histopathology revealed a tumor compatible with pure nongestational ovarian choriocarcinoma. Adjuvant chemotherapy was performed based on 4 courses of bleomycin-etoposide-cisplatin (BEP) regimen. She is now under chemotherapy. Conclusions:We recommend the use of minimally invasive, fertility-preserving surgeries in patients with non-gestational ovarian choriocarcinomas.

Nongestational ovarian choriocarcinoma with bilateral teratoma: A rare case report and literature review

“…NGCO is an extremely rare malignant germ cell tumor, accounting for 1% of ovarian germ cell tumors, common in adolescents and young women and occasionally detected in postmenopausal women. [ 2 ] Herein, we systematically searched the literature written in English published in PubMed, Cochrane Library, and Embase from 2000 to date. In total, 35 cases, including the present case report, are summarized in Table 1 , excluded an article published in 2001 reported by Goswami et al [ 3 ] about 30 cases of pure NGCO.…”

An Atypical Presentation of Non-Gestational Choriocarcinoma During the COVID-19 Pandemic: A Case Report

“…Non-gestational choriocarcinoma is extremely rare, with an incidence of 1/369,000,0004. It comprises 2.1% of all malignant germ cell tumors and less than 1% of all ovarian tumors [5][6][7].…”

“…Often multiagent combination chemotherapy is required, particularly when distant metastases are present, Beta-hCG is >40,000 or in the case of gestational choriocarcinoma the interval since pregnancy is >4 months2. Examples of a chemotherapy regimen include adjuvant cisplatin, etoposide, and bleomycin or EMA/CO regimen consisting of etoposide, methotrexate, dactinomycin, cyclophosphamide, and vincristine can be used [3,4,6]. Beta-hCG is a good indicator of prognosis and treatment response [2,8].…”

Non-gestational choriocarcinoma of the ovary: A case report

“…NGCO is an extremely rare malignant germ cell tumour with incidence of less than 1% of all ovarian germ cell tumours, nonetheless it is prevalent among women of reproductive age especially adolescents. 4 The clinical symptoms of the disease are normally non-specific and may include abdominal pain and vaginal bleeding. 8 These symptoms mimic the presentations of other more common conditions occurring in young women, such as tubo-ovarian abscess and ectopic pregnancy.…”

“… 3 Epidemiologically, the gestational type is more common than the non-gestational type, and only a few cases of non-gestational choriocarcinoma of the ovary (NGCO) have been reported in the literature worldwide. 4 Generally, NGCO have been clinically diagnosed in female patients who were sexually immature, unable to conceive, or have never had sexual intercourse. 5 Ovarian germ cell tumours commonly occur in the first two decades of life, but can also be seen in any age group.…”