Primary Radiation Therapy for Early Breast Cancer

Harris, Rachel; Mb, Levene; Hellman, Samuel

doi:10.1159/000383868

Cited by 3 publications

(2 citation statements)

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“…This approach has been used since the 1980s. 19 Computed tomography is currently being used, as described later, to simulate radiation therapy, thereby allowing avoidance of radiation exposure to the lung and heart, the correction of underlying lung density, and optimization of compensation. 20,21 Although early complications of breast irradiation, including skin erythema and irritation, are commonly BCT, breast-conserving therapy; XRT, X-ray therapy; Lump, lumpectomy observed, they minimally influence the patient's quality of life.…”

Section: Significance and Complications Of Breast Irradiationmentioning

confidence: 99%

Radiation therapy after breast-conserving surgery

et al. 2006

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The authors critically reviewed previous articles concerning the significance of breast irradiation following breast-conserving surgery in terms of the following subject items: indications for breast-conserving therapy, the significance and complications of breast irradiation, the timing of the start of breast irradiation, the significance of boost irradiation, the potential improvement of survival with systemic therapy plus breast irradiation, the significance of axillary dissection, indications and the significance of regional nodal irradiation, accelerated hypofractionated radiotherapy, omission of breast irradiation in low-risk patients, and future directions. In addition, our previously reported results of breast irradiation following breast-conserving surgery at the Keio University Hospital are outlined. Our newly developed tangential irradiation technique directed to the axilla and a recently introduced three-dimensional simulation technique for radiotherapy treatment planning are also presented.

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Section: Significance and Complications Of Breast Irradiationmentioning

confidence: 99%

Radiation therapy after breast-conserving surgery

et al. 2006

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“…Although physicians agree on the desirability of these ends, argument over the best means to accomplish them is often heated. Reports from single institutions [1][2][3][4][5][6][7][8] describing the outcome of various treatment techniques have been extremely encouraging in the movement away from disfiguring surgery. From such experiences, there are strong indications that treatment programs other than radical surgery, usually radiation therapy incorporated with limited surgical procedures, may well be capable of achieving comparable cure rates.…”

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Mastectomy versus radiotherapy as treatment for stage I‐II breast cancer: A prospective randomized trial at the National Cancer Institute

et al. 1985

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In 1979, the National Cancer Institute in Bethesda, Maryland initiated a randomized, prospective trial to compare surgery versus radiation therapy in the treatment of stages I and II breast cancer. Surgical treatment consists of total mastectomy with axillary lymph node dissection (modified radical mastectomy) and breast reconstruction; radiation treatment consists of gross tumor excision, axillary lymph node dissection, and comprehensive irradiation including a boost dose to the tumor bed. All patients with pathologically positive axillary nodes receive 11 cycles of adjuvant Adriamycin®/Cytoxan® chemotherapy. As of December 1984, there have been 175 patients entered in the study. Twenty‐three patients have developed disease recurrence (12 mastectomy, 11 radiation), but it is too early to obtain definitive treatment‐related results.

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IS LESS THAN MASTECTOMY A SAFE OPTION?

Langlands

Tiver

1982

Australian and New Zealand Journal of Surgery

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Studies of the curability of breast cancer are reviewed. Of patients presenting with early disease, who are treated by ablative surgery, with or without postoperative radiotherapy, the proportion cured is small, with estimates of that proportion ranging from 0–30%. This fact must seriously modify arguments that failure to carry out a particular form of local treatment Jeopardizes an individual patient's chances of cure. Techniques now exist whereby the breast can be conserved with acceptable cosmetic results in up to 90% of patients and with a salvage mastectomy rate of 10–15% at 10 years. These techniques can safely be applied to patients with tumours up to 5 cm in diameter whether or not homolateral nodes are palpable. Both survival rates and local recurrence rates are equivalent to those obtained by more radical surgery. Data from two clinical trials and numerous uncontrolled studies are reviewed and support these conclusions. A rigid application of a policy of total mastectomy as recommended by the Consensus Development Conference cannot be Justified by arguments that alternative treatment carries with It an increased risk of recurrence or death. Such arguments are not supported by the data available in the literature. Strict rules regarding tumour size or the palpability of axillary nodes, which make conservation a safe alternative to mastectomy, are equally illogical and are also not supported by the data available. True and valid consent by a patient to any procedure requires a fair discussion of alternatives. We believe that the evidence that less than mastectomy Is a safe alternative to radical surgery is so strong every woman presenting with operable breast cancer is entitled to discuss this approach to her management.

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Primary Radiation Therapy for Early Breast Cancer

Cited by 3 publications

References 0 publications

Radiation therapy after breast-conserving surgery

Radiation therapy after breast-conserving surgery

Mastectomy versus radiotherapy as treatment for stage I‐II breast cancer: A prospective randomized trial at the National Cancer Institute

IS LESS THAN MASTECTOMY A SAFE OPTION?

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