Primary radiation therapy in the treatment of anal carcinoma

Cantril, Simeon T.; Green, Jerold P.; Schall, Gerald L.; Schaupp, Willis C.

doi:10.1016/0360-3016(83)90257-2

Cited by 85 publications

(12 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…39,56,[64][65][66][67][68][69][70][71][72][73] It is difficult to establish how many patients achieved permanent tumor control with RT and whether any subsequent surgery was required for recurrence or for complications of irradiation from these studies. However, these reports seemed to suggest that RT has similar five-year survival rates compared with surgery, with serious complications in approximately 3 to 10 percent.…”

Section: Effectiveness Of Radiotherapymentioning

confidence: 99%

Management of Anal Canal Cancer

Sato

Koh

Bartolo

2005

Diseases of the Colon &Amp; Rectum

View full text Add to dashboard Cite

To improve treatment outcomes and reduce treatment-related toxicities, further studies are required to elucidate the optimal drug combination and doses, optimal radiation field, total dose, and fraction sizes. Randomized, multicenter trials are needed to define the treatment protocol that provides the highest rate of sphincter preservation with acceptable toxicity. Few studies addressed the treatment of metastatic disease, which remains a major cause of mortality.

show abstract

Section: Effectiveness Of Radiotherapymentioning

confidence: 99%

Management of Anal Canal Cancer

Sato

Koh

Bartolo

2005

Diseases of the Colon &Amp; Rectum

View full text Add to dashboard Cite

show abstract

“…A particularly exciting development in the last 15 years has been the demonstration that epidermoid carcinoma of the anus, the most prevalent histology, is sensitive to combined modality treatment involving radiation therapy and infusional 5‐fluorouracil (5‐FU)‐based chemotherapy 4‐6. Numerous single‐institution and multi‐institution trials have demonstrated that low to moderate doses of radiation therapy (30‐50 Gy) in conjunction with chemotherapy can achieve results that compare favorably with historical controls treated with radical surgery or high dose radiation 6‐15. The functional results and colostomy free survival are generally excellent.…”

mentioning

confidence: 99%

The national cancer data base report on carcinoma of the anus

Myerson

Karnell

Menck

1997

Cancer

107

View full text Add to dashboard Cite

BACKGROUND The last 15 years have seen substantial advances in the management of anal carcinoma, primarily in the use of radiochemotherapy as definitive or adjuvant treatment. This study reviews the patterns of presentation, care, and outcome reflected in data from the National Cancer Data Base representing a broad range of medical centers. METHODS Data on patients with anal carcinoma (on 1050 patients from 1988 and 1289 patients from 1993) were reviewed for patterns of care and presentation. The 1988 cases were also reviewed for outcome data. RESULTS There was an increase in the use of chemotherapy between 1988 and 1993 (from 61.6% to 67.2%), and substantial differences were observed in the management of epidermoid carcinomas and adenocarcinomas. The majority of epidermoid carcinomas were managed nonsurgically, principally with combined chemotherapy and radiation, whereas three‐fourths of patients with adenocarcinoma underwent surgery. The most important factors for favorable 5‐year survival were early stage (ranging from 71.3% for Stage I to 23.1% for Stage IV), epidermoid carcinoma histology (57.6%, compared with 41.3% for adenocarcinoma), and female gender (56.2%, compared with 49.6% for males). For Stage I‐II epidermoid carcinomas, the 5‐year survival for patients who received nonsurgical treatment with radiochemotherapy was equivalent to that of patients who received surgical treatment (64.0% and 65.4%, respectively). CONCLUSIONS This study confirms a trend in patterns of care favoring nonsurgical management with radiochemotherapy for epidermoid carcinomas of the anus. For adenocarcinomas, there has been a trend toward increasing use of multimodality therapy with surgery and adjuvant radiochemotherapy. Survival data from the 1988 cases confirmed the efficacy of conservative treatment with radiation plus chemotherapy for epidermoid carcinomas. Cancer 1997; 80:805‐15. © 1997 American Cancer Society.

show abstract

“…Although the total radiation dose is known to affect local control2,3 the benefit of a high dose over 60 Gy may be doubtful and a high radiation dose may be associated with complications 4,5. Whether or not the addition of inguinal irradiation is beneficial also remains controversial.…”

Section: Introductionmentioning

confidence: 99%

Long-Term Outcomes of Chemoradiation for Anal Cancer Patients

et al. 2013

View full text Add to dashboard Cite

PurposeThe aim of this study was to evaluate long-term oncologic outcomes after concurrent chemoradiation treatment for anal cancer.Materials and MethodsBetween January 1979 and December 2008, the records of 50 consecutive patients with anal cancer and who were treated by chemoradiation or radiation only with a curative intent were retrospectively reviewed. The oncologic outcomes and the risk factors for recurrence were analyzed.ResultsOf the 50 patients, 49 underwent concurrent chemoradiation and one underwent radiation only. After these definitive treatments, 43 (86.0%) achieved a clinical complete response. During the median follow-up of 60 months (range: 2-202 months), the 5-year overall survival, disease-free survival, and locoregional recurrence-free survival were 84.2%, 72.7%, and 69.9%, respectively. Multivariate analysis revealed that the performance status (p=0.031) and a clinical complete response (p=0.039) were the independent predictors for overall survival; lymph node involvement (p=0.031) was the only independent predictor for disease-free survival.ConclusionThe performance status and a clinical complete response may be reliable predictors of survival after chemoradiation for anal cancer. The addition of irradiation to the inguinal area may not be significantly associated with the outcomes.

show abstract

Primary radiation therapy in the treatment of anal carcinoma

Cited by 85 publications

References 30 publications

Management of Anal Canal Cancer

Management of Anal Canal Cancer

The national cancer data base report on carcinoma of the anus

Long-Term Outcomes of Chemoradiation for Anal Cancer Patients

Contact Info

Product

Resources

About