Primary recurrent orbital schwannoma treated with surgical excision and Mitomycin-C

Leung, Kai Ching Peter; Lam, Nerissa Kei Yen; Chan, Edwin; Ko, Tak Chuen Simon

doi:10.1016/j.ajoc.2020.100784

Cited by 4 publications

(8 citation statements)

References 12 publications

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“…In addition, recurrence of orbital schwannoma is most likely associated with neurofibromatosis type 2 or schwannomatosis. [ 12 , 13 ] Though the clinical follow-up in our patient showed improvement in the visual acuity and no muscle cone lesions in the orbital CT scan, we need to follow-up the patient for a long time period due to the possibility of recurrence.…”

Section: Discussionmentioning

confidence: 85%

“…When there are multiple recurrences and in cases where total excision is not possible, addition of topical Mitomycin-C may be an option to bring about tumor regression. [ 12 ] However, it was not a best option in our case, because topical MMC may cause the optic nerve damage. In this case, there was no postoperative visual damage, and amazingly her visual acuity improved during follow-up.…”

Section: Discussionmentioning

confidence: 86%

“…[ 11 ] Radiotherapy is an alternative treatment but is limited by unknown efficacy and collateral radiation damage. [ 12 ] It is very important to take appropriate preoperative assessment of the tumors by orbital imaging, due to its variable presentation and location. In some cases, the lesions are in special locations, and the total resection can lead to serious complications.…”

Section: Discussionmentioning

confidence: 99%

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Orbital schwannoma with calcification treated by intracapsular excision

Ren

Wu²,

Li³

et al. 2021

Medicine

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Rationale: Orbital schwannoma is a relatively rare orbital tumor, and calcification of the lesion is rarely found in the orbit. We report a case of orbital schwannoma which was characterized by calcification in the orbital muscle cone, and was cured by intracapsular excision. Patient concerns: A 54-year-old female with a complaint of a mass in the left orbit during a magnetic resonance imaging examination and symptom of dizziness 6 months before, presented with painless exophthalmos and vision decline in the left eye. Diagnoses: According to clinical manifestations, imaging examinations and postoperative immunohistochemical examinations, the diagnosis was orbital schwannoma, with calcification in the muscle cone. Interventions: The patient was treated by intracapsular excision of the left orbit. We removed the intracapsular mass and most part of the cyst wall in order to prevent orbital apex syndrome. Outcomes: The diagnosis of schwannoma with calcification was confirmed finally through histological and immunohistochemical exam. The patient was followed up for 28 months and the orbital CT scan showed that there were no significant lesions found in the orbital muscle cone. Lessons: Understanding clinical, imaging diagnostic, and histopathological features of rare orbital schwannoma with calcification will facilitate timely diagnosis and treatment of this condition. The intracapsular excision can help in avoiding complications.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

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Orbital schwannoma with calcification treated by intracapsular excision

Ren

Wu²,

Li³

et al. 2021

Medicine

View full text Add to dashboard Cite

show abstract

“…Schwannomas found within or adjacent to the orbit are rare and represent only 1% of all orbital neoplasms [4] . A lone schwannoma in the orbit without association to NF is called primary orbital schwannoma [5] . Having multiple orbital ones is often NF-associated.…”

Section: Dear Editormentioning

confidence: 99%

“…The patient also has to be assessed for other NF2 manifestations such as hearing loss, numbness, and weakness of the extremities and appropriate referrals shall be made. Even though orbital schwannomas are usually asymptomatic, surgery is a mainstay in its management [5][6] . Schwannomas are commonly well-circumscribed, encapsulated solitary masses that adhere to the nerve, but can be separated from the nerve origin with careful dissection to avoid nerve transection.…”

Section: Dual Variant Schwannomas In Orbital Schwannomatosismentioning

confidence: 99%