Primary Renal Candidiasis

Tennant, Forest S.

doi:10.1001/archinte.1968.00040010435012

Cited by 41 publications

(2 citation statements)

References 15 publications

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“…When this obstruction occurred, the renal pelvis was grossly distended by masses (9). In addition to the presence of Candida in the urine and kidneys of infected animals, the occurrence of masses of pseudomycelium and necrotic debris within the renal pelvis, and often in the ureter, causing obstruction, is similar to the conditions found in human renal candidiasis (9,10,13).…”

Section: Resultsmentioning

confidence: 82%

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Experimental Urinary Tract Infection in Rats Caused by Candida albicans

Miraglia

Renz

1973

Antimicrob Agents Chemother

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The increased clinical use of broad-spectrum antibiotics, immunosuppressives, and anti-inflammatory agents is thought to have contributed to the increased incidence of renal infections due to Candida albicans. To aid in the search for improved anticandidal agents, we developed an experimental model in which C. albicans is injected into the medulla of the surgically exposed kidney of the rat. The ensuing infection is restricted to the urinary tract and can be treated successfully with amphotericin B. This model promises to be of merit in the evaluation of agents potentially useful in treating candidiasis of the urinary tract.

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Section: Resultsmentioning

confidence: 82%

“…and enterococci (2), Candida albicans has been isolated from urine with increasing frequency (1). The increasing incidence of urinary tract candidiasis (3,4,9,10,13) is often a consequence of the alteration of host resistance, especially after therapy with immunosuppressive agents, anti-inflammatory drugs, or broad-spectrum antibiotics (10).…”

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confidence: 99%

Experimental Urinary Tract Infection in Rats Caused by Candida albicans

Miraglia

Renz

1973

Antimicrob Agents Chemother

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Candida at Boston City Hospital

Toala¹

1970

Arch Intern Med

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Treatment of Funguria

Wong-Beringer

Jacobs²,

Guglielmo³

1992

JAMA

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We evaluated the use of antifungal agents in the treatment of uncomplicated funguria by reviewing all case reports and studies regarding the treatment of funguria published in the English language from 1960 to 1991 (MEDLINE). Adult patients treated for uncomplicated funguria were included. Patients with fungal pyelonephritis and/or other systemic fungal manifestations were excluded from our analysis. All investigations were assessed for study design, sample size, definition of significant funguria, treatment regimen, inclusion of predisposing risk factors in outcome analysis, end points of therapy, and patient follow-up. Direct comparison of the studies on the use of antifungals in the treatment of uncomplicated funguria was not possible given the differing definitions of significant funguria, inconsistent reporting of risk factors, varying treatment regimens, end points of therapy, and duration of follow-up. Case reports and studies involving antifungals such as amphotericin B bladder irrigation, miconazole nitrate bladder irrigation, ketoconazole, and flucytosine were reviewed. Amphotericin B bladder irrigation appeared to be most effective and ketoconazole the least effective treatment of uncomplicated funguria. Predisposing risk factors, such as the presence of an indwelling urinary catheter, appear to play an important role in the persistence of positive cultures and failure of pharmacologic interventions. Until prospective, well-controlled studies are performed, no recommendation can be made for the treatment of uncomplicated funguria. In symptomatic patients therapy is indicated; however, the best regimen is unknown.

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Primary Renal Candidiasis

Cited by 41 publications

References 15 publications

Experimental Urinary Tract Infection in Rats Caused by Candida albicans

Experimental Urinary Tract Infection in Rats Caused by Candida albicans

Candida at Boston City Hospital

Treatment of Funguria

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