Primary renal graft thrombosis

Bakir, N; Sluiter, Wj; Ploeg, R; Son, WJ van; Tegzess, Adam

doi:10.1093/ndt/11.1.140

Cited by 101 publications

(59 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In our study the incidence in children aged less than 2 years was 18%. We also identified an incidence of 4% in the older children (aged 10 years or older), a figure similar to the 2%-7% reported in adults [9]. Our overall incidence of 10% graft thrombosis is higher than that reported in children in other studies, for example by the North American Renal Transplant Cooperative Study (NAPRTCS) [3].…”

Section: Discussionsupporting

confidence: 84%

The effect of heparin on graft thrombosis in pediatric renal allografts

et al. 2004

View full text Add to dashboard Cite

Graft thrombosis is an important cause of early (<4 weeks) renal graft loss. Reports show that heparin reduces the incidence of early renal allograft thrombosis. Routine peri-operative administration of unfractionated heparin was introduced in our unit in 1994. We conducted a retrospective study of 254 transplants, undertaken in children, between 1987 and 2000. There were 126 children who did not receive heparin (group 1) and 128 who did (group 2). Recipient characteristics and immunosuppression were similar in both groups. The incidence of graft loss secondary to thrombosis was compared between the groups. Variables previously identified with increased risk of graft loss, including donor age, recipient age, cold ischaemia time (CIT), multiple donor vessels, surgical complications, and side of graft donation, were examined using logistic regression. Thrombosis occurred in 14 grafts in group 1 and 11 grafts in group 2 (odds ratio 0.7, 95% confidence interval 0.3-1.6, P=not significant). The mean time to graft loss was similar in groups 1 and 2 (6.6, SD 3.9, range 2-12 days and 7.9, SD 4.4, range 1-14 days, respectively) ( P=0.445). Young recipient age ( P=0.006), young donor age ( P=0.009), increasing CIT ( P=0.007), and surgical complications ( P=0.002) increased the risk of graft thrombosis. A reduction in the incidence of early renal allograft thrombosis upon introduction of heparin was not demonstrated.

show abstract

Section: Discussionsupporting

confidence: 84%

The effect of heparin on graft thrombosis in pediatric renal allografts

et al. 2004

View full text Add to dashboard Cite

show abstract

“…In one large series, 2.2% of renal transplants were complicated by graft thrombosis, with 90% of cases occurring within the first 2 weeks (6). In another study, arterial or venous graft thrombosis accounted for nearly 50% of early graft loss within the first 3 months (5). Risk factors for renal graft thrombosis include prior peritoneal dialysis, retransplantation, extremes of donor age, multiple renal vessels, prolonged cold ischemia time, hypotension, and a history of venous thrombosis (3).…”

Section: Thromboembolic Complications After Renal Transplantationmentioning

confidence: 98%

“…All DVT were objectively confirmed by duplex Doppler ultrasound or venography. Primary graft vessel thrombosis affects 1% to 7% of renal transplants and usually results in graft loss (3)(4)(5). In one large series, 2.2% of renal transplants were complicated by graft thrombosis, with 90% of cases occurring within the first 2 weeks (6).…”

Section: Thromboembolic Complications After Renal Transplantationmentioning

confidence: 99%

Thrombophilia and Thrombotic Problems in Renal Transplant Patients

Kujovich¹

2004

Transplantation

View full text Add to dashboard Cite

“…Renal allograft thrombosis due to any cause accounts for 2% to 7% of early allograft loss, with renal vein thrombosis (RVT) almost twice as frequent as arterial thrombosis [3,4]. RVT typically arises in the first 2 weeks after transplantation.…”

Section: Introductionmentioning

confidence: 99%

“…Kinks, compression, and torsion of the renal vein may also contribute to the development of RVT. Thrombophilic states, including protein C and S deficiency, factor V Leiden, prothrombin G20210A, anti-thrombin III deficiency, and anticardiolipin and antiphospholipid antibodies, may also be associated with higher frequency of RVT [3][4][5]. Recurrent membranous nephropathy has also been associated with development of RVT later in the posttransplant period [6].…”

Section: Introductionmentioning

confidence: 99%